Amiodarone‐induced thyrotoxicosis: Is there a place for surgery?
Abstract
Amiodaroneinduced hyperthyroidism has on most instances been reported as mild, and thyroid functions return to normal after discontinuation of the drug. Nevertheless, lifethreatening amiodaroneinduced thyrotoxicosis has also been described. Conventional treatments such as antithyroid drugs (thionamide) and corticosteroids are essentially ineffective or fail to alter the dramatic course of the thyroid crisis. This limited effectiveness of medical therapy, particularly in patients with previously neglected or unknown thyroid disease, prompted us to intervene surgically. We report a series of nine patients who underwent total or neartotal thyroidectomy as a firstline therapy for five of them. Surgery resulted in rapid resolution of thyrotoxicosis with an uneventful postoperative course. This approach has the advantage of immediate effectivity, low risk of relapse, and appears to be the only treatment that permits continued therapy with amiodarone when the drug appears needed to control a lifethreatening arrhythmia.
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Several surgical series involving patients with AIT have now been published, with generally favorable results.
“Several surgical series involving patients with AIT have now been published, with generally favorable results (612,(614)(615)(616).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [614]
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- Authors
- Meurisse, M., Hamoir, E., D'Silva, M., Joris, J., & Hennen, G.
- Affiliations
- Centre Hospitalier Universitaire de Liège (BE)
- Departments of Endocrine Surgery, Anesthesiology, and Endocrinology Centre Hospitalier Universitaire Domaine du Sart‐Tilman Liege Belgium
- ORCID
- Joris, Jean
- Venue
- World Journal of Surgery
- Publisher
- Wiley
- Published
- 1993-09
- Volume
- 17
- Issue
- 5
- Pages
- 622-626
- ISSN
- 0364-2313 (ISSN-L)
- 1432-2323
- OpenAlex
- W2083088667
- Cited by
- 43
- References
- 29
- Citations by year
- 2025: 1 · 2023: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 2
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- World Journal of Surgery (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- amiodarone, thyrotoxicosis, hyperthyroidism, thyroidectomy, total thyroidectomy, drug-induced thyroid dysfunction, antithyroid drugs, corticosteroids, thyroid storm, cardiac arrhythmias
- MeSH terms
- Aged, Aged, 80 and over, Amiodarone, Female, Humans, Male, Middle Aged, Thyroidectomy, Thyrotoxicosis
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