The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The oxidative desaturation of unsaturated fatty acids in animals
Open accessAbstract
SummaryThe progress made in the knowledge of the microsomal fatty acid desaturation reaction is described:1.Studies suggest that different enzymes produce 9, 6, and 5-desaturation.2.The 6-desaturation of fatty acids would be the principal regulatory step in the biosynthesis of polyunsaturated fatty acids in rat microsomes.3.The desaturation of fatty acids is quantitatively modified by competitive reactions among acids of the same or different families, and by competition with fatty acid incorporation in the lipids.4.Dietary components, especially carbohydrates and protein modify quantitatively the fatty acid desaturation. Protein would induce the 6-desaturation reaction.5.Insulin modifies the 6-desaturation reaction through a dual effect: one modifying glucose metabolism, and the other through enzymatic induction.6.ATP increases the 6-desaturation of fatty acids.7.By mild extraction of the microsomes with buffered KCl sucrose solution, a “soluble” fraction was separated that was necessary for a full desaturation activity of the microsomes. The nature of this factor is discussed.8.The main features that characterize the 6-desaturation reaction are discussed and the possible structure of the enzyme outlined.
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Cites
A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET
Burr, G. O., & Burr, M. M. (1929) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)78281-5 · Cited by 1,185
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Self-citationA Function of Cytochrome b5 in Fatty Acid Desaturation by Rat Liver Microsomes
OSHINO, N., IMAI, Y., & SATO, R. (1971) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a129444 · Cited by 387
Biochemical Problems of Lipids
(1964) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(64)80465-x · Cited by 354
Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes
Oshino, N., Imai, Y., & Sato, R. (1966) · Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation · doi:10.1016/0926-6593(66)90137-8 · Cited by 285
The desaturation step in the animal biosynthesis of polyunsaturated fatty acids
Brenner, R. R. (1971) · Lipids · doi:10.1007/bf02531137 · Cited by 232
Self-citationThe dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver
Oshino, N., & Sato, R. (1972) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(72)90335-9 · Cited by 213
SHIMAKATA, T., MIHARA, K., & SATO, R. (1972) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a130004 · Cited by 174
The preferred metabolic pathway from linoleic acid to arachidonic acid in vitro
Marcel, Y. L., Christiansen, K., & Holman, R. T. (1968) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(68)90067-2 · Cited by 160
A Requirement for Lipids by the Microsomal Stearyl Coenzyme A Desaturase
Jones, P. D., Holloway, P. W., Peluffo, R. O., & Wakil, S. J. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94415-7 · Cited by 158
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Metabolism and Functions of Lipids and Fatty Acids in Teleost Fish
Tocher, D. R. (2003) · Reviews in Fisheries Science · doi:10.1080/713610925 · Cited by 2,606
Stubbs, C. D., & Smith, A. D. (1984) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(84)90005-4 · Cited by 1,618
Essential fatty acids in growth and development
Innis, S. M. (1991) · Progress in Lipid Research · doi:10.1016/0163-7827(91)90006-q · Cited by 921
Metabolism of highly unsaturated n-3 and n-6 fatty acids
Sprecher, H. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00077-9 · Cited by 868
Nutritional and hormonal factors influencing desaturation of essential fatty acids
Brenner, R. R. (1981) · Progress in Lipid Research · doi:10.1016/0163-7827(81)90012-6 · Cited by 549
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Metadata
- Authors
- Brenner, R. R.
- Venue
- Molecular and Cellular Biochemistry
- Published
- 1974-03
- Volume
- 3
- Issue
- 1
- Pages
- 41-52
- ISSN
- 0300-8177 (ISSN-L)
- 1573-4919
- OpenAlex
- W2053672369
- Cited by
- 391
- References
- 30
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- green
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