Hemophilia treatment in historical perspective: a review of medical and social developments
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In the early 1980s, unknowingly contaminated therapeutic proteins from human plasma caused widespread transmission of viruses such as HIV to people with haemophilia who received these treatments.
“In the early 1980's, unknowingly contaminated therapeutic proteins from human plasma caused widespread transmission of viruses, such as human immunodeficiency virus (HIV), to people with haemophilia who received these treatments 5,6 .”
From Viral contamination in biologic manufacture and implications for emerging therapies (2020) · cites this paper as [5]
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The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex
Fischl, M. A., Richman, D. D., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Schooley, R. T., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170401 · Cited by 2,995 · see citing works
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Viral contamination in biologic manufacture and implications for emerging therapies
Barone, P. W., Wiebe, M. E., Leung, J. C., Hussein, I. T. M., Keumurian, F. J., Bouressa, J., Brussel, A., Chen, D., Chong, M., Dehghani, H., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0507-2 · Cited by 212 · see citing works
- Authors
- Rosendaal, F. R., Smit, C., & Briët, E.
- Affiliations
- Leiden University Medical Center (NL)
- Venue
- Annals of Hematology
- Published
- 1991-02
- Volume
- 62
- Issue
- 1
- Pages
- 5-15
- ISSN
- 0939-5555 (ISSN-L)
- 1432-0584
- OpenAlex
- W2012565460
- Cited by
- 83
- References
- 1
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 6 · 2018: 1 · 2017: 2 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Annals of Hematology (publishedVersion)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Leiden Repository (Leiden University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hemophilia Treatment and Research
- Social Sciences › Arts and Humanities › History › Medical History and Innovations
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
- Keywords
- hemophilia, hemophilia treatment, history of hemophilia, medical history, social history, bleeding disorders
- MeSH terms
- Acquired Immunodeficiency Syndrome, Autoantibodies, Factor IX, Factor VIII, Hemophilia A, Hepatitis, Viral, Human, Humans, Life Expectancy, Male, History, 19th Century, History, 20th Century, History, Ancient, History, Medieval, Transfusion Reaction
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