Cited by 40Pharmacogenetics and Drug MetabolismGut microbiota and healthInflammatory Bowel Disease

Bacterial acetylation of 5-aminosalicylic acid in faecal suspensions cultured under aerobic and anaerobic conditions

van Hogezand, R. A., Kennis, H. M., van Schaik, A., Koopman, J. P., van Hees, P. A. M., van Tongeren, J. H. M.·1992·European Journal of Clinical Pharmacology

Abstract

After oral administration of 5-aminosalicylic acid a substantial proportion of the acetylated form is excreted in the faeces. We have studied the role of the faecal microflora in acetylating 5-aminosalicylic acid. In faeces incubated under both aerobic and anaerobic conditions there was acetylation of 5-aminosalicylic acid. Of the anaerobic bacteria isolated from a 10(8) faecal dilution 44% were able to acetylate 5-aminosalicylic acid. We conclude that the normal faecal microflora contribute to the acetylation of 5-aminosalicylic acid.

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Crossref · 10.1007/bf01740669

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  • 5-ASA can be converted to N-acetyl 5-ASA by intestinal bacteria, a reaction that shows variability in human fecal samples.

    “5-ASA can be converted to N-acetyl 5-ASA by intestinal bacteria, a reaction that does show variability in human fecal samples (van Hogezand et al., 1992).”

    From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as van Hogezand et al., 1992

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Authors
van Hogezand, R. A., Kennis, H. M., van Schaik, A., Koopman, J. P., van Hees, P. A. M., & van Tongeren, J. H. M.
Affiliations
Radboud University Nijmegen (NL)
Venue
European Journal of Clinical Pharmacology
Published
1992-03
Volume
43
Issue
2
Pages
189-192
ISSN
  • 0031-6970 (ISSN-L)
  • 1432-1041
OpenAlex
W1995278557
Cited by
40
References
21
Citations by year
2026: 2 · 2025: 5 · 2023: 6 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 2 · 2014: 2 · 2013: 2
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Clinical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords
5-aminosalicylic acid, fecal microbiota, anaerobic bacteria, aerobic conditions, anaerobic conditions, oral administration
MeSH terms
Acetylation, Aerobiosis, Aminosalicylic Acids, Anaerobiosis, Bacteria, Bacteriological Techniques, Feces, Humans, Mesalamine

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