Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice.
Abstract
The unresponsiveness to LPS detected in C57BL/10Cr mice is inherited as a recessive trait and is determined by an autosomal gene linked to theMup-1 locus on chromosome 4. Since no complementation for LPS responsiveness was observed in F(1) hybrid mice between C3H/HeJ and C57BL/10Cr, we conclude that C57BL/10Cr mice carry a defective allele at the sameLps locus, previously identified by the mutation detected in the C3H/HeJ strain.
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LPS signaling is mediated by TLR4, as mutations or deletions of Tlr4 locus completely abolish LPS-mediated signaling.
“LPS signaling is mediated by TLR4 since mutations or deletions of the Tlr4 locus completely abolish LPS-mediated signaling [26], [27].”
From MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State (2012) · cites this paper as [27]
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works
Beutler, B. A. (2009) · Blood · doi:10.1182/blood-2008-07-019307 · Cited by 840 · see citing works
Saba, R., Gushue, S., Huzarewich, R. L. C. H., Manguiat, K., Medina, S., Robertson, C., & Booth, S. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030832 · Cited by 151 · see citing works
Michel, O., LeVan, T. D., Stern, D., Dentener, M., Thorn, J., Gnat, D., Beijer, M. L., Cochaux, P., Holt, P. G., Martinez, F. D., et al. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.05.001 · Cited by 147 · see citing works
- Authors
- Coutinho, A., & Meo, T.
- Venue
- Immunogenetics
- Published
- 1978-12
- Volume
- 7
- Issue
- 1
- Pages
- 17-24
- ISSN
- 0093-7711
- 1432-1211
- Cited by
- 101
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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