Spontaneous neoplasms in aged Sprague-Dawley rats
Abstract
Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid parafollicular cell adenomas (3.6%), fibromas and squamous cell papillomas of the skin and hepatocellular adenomas (2.0% in each), malignant lymphoma lymphocytic (1.9%), histiocytic sarcomas (1.4%), and adrenal cortical adenomas (1.2%). In female rats, the most common neoplasms were of mammary gland origin (31.3%: fibroadenoma 19.0%, adenocarcinomas 8.8%, and adenomas 3.5%) followed by thyroid parafollicular cell adenomas (2.9%), uterine endometrial stromal polyps (2.6%), adrenal cortical adenomas (1.9%), malignant lymphoma lymphocytic (1.6%), fibromas in the skin (1.3%), and pancreatic islet cell adenoma (1.1%). Metastases were observed from pheochromocytomas, hepatocellular carcinomas, nephroblastomas, renal pelvis transitional cell carcinoma, interstitial cell tumor and seminoma of the testes, Zymbal's gland adenocarcinomas, and mammary adenocarcinomas.
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All treatments in both sexes enhanced large tumor incidence by 2-3-fold in comparison to controls, and also the number of mammary tumors in comparison to the same Harlan Sprague Dawley strain, and overall around 3-fold in comparison to the largest study with 1329 Sprague Dawley female rats.
“All treatments in both sexes enhanced large tumor incidence by 2-3-fold in com- parison to our controls but also for the number of mammary tumors in comparison to the same Harlan Sprague Dawley strain (Brix et al., 2005), and overall around 3-fold in comparison to the largest study with 1329 Sprague Dawley female rats (Chandra et al., 1992).”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Chandra et al., 1992
All treatments in both sexes enhanced large tumor incidence by two- to threefold in comparison to controls and also the number of mammary tumors in comparison to the Harlan Sprague-Dawley strain and overall around threefold in comparison to the largest study with 1,329 Sprague-Dawley female rats.
“All treatments in both sexes enhanced large tumor incidence by two- to threefold in comparison to our controls and also the number of mammary tumors in comparison to the Harlan Sprague-Dawley strain [56] and overall around threefold in comparison to the largest study with 1,329 Sprague-Dawley female rats [57].”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [57]
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- Authors
- Chandra, M., Riley, M. G. I., & Johnson, D. E.
- ORCID
- Johnson, Dale E.
- Venue
- Archives of Toxicology
- Published
- 1992-08
- Volume
- 66
- Issue
- 7
- Pages
- 496-502
- ISSN
- 0340-5761 (ISSN-L)
- 1432-0738
- OpenAlex
- W2081611632
- Cited by
- 117
- References
- 37
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 7
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Veterinary Oncology Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- spontaneous neoplasms, tumor incidence, mammary tumors, pheochromocytoma, keratoacanthoma, pancreatic islet cell adenoma, adrenal adenoma, lymphoma, metastasis
- MeSH terms
- Adenoma, Aging, Animals, Bone Neoplasms, Brain Neoplasms, Digestive System Neoplasms, Disease Models, Animal, Female, Kidney Neoplasms, Male, Neoplasms, Pituitary Gland, Anterior, Pituitary Neoplasms, Respiratory Tract Neoplasms, Rodent Diseases, Spinal Cord Neoplasms, Testicular Neoplasms, Mammary Neoplasms, Animal, Incidence, Endometrial Neoplasms, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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