Cited by 117Carcinogens and Genotoxicity AssessmentVeterinary Oncology ResearchImmunotoxicology and immune responses

Spontaneous neoplasms in aged Sprague-Dawley rats

Chandra, Manik, Riley, Michael G. I., Johnson, Dale E.·1992·Archives of Toxicology

Abstract

Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid parafollicular cell adenomas (3.6%), fibromas and squamous cell papillomas of the skin and hepatocellular adenomas (2.0% in each), malignant lymphoma lymphocytic (1.9%), histiocytic sarcomas (1.4%), and adrenal cortical adenomas (1.2%). In female rats, the most common neoplasms were of mammary gland origin (31.3%: fibroadenoma 19.0%, adenocarcinomas 8.8%, and adenomas 3.5%) followed by thyroid parafollicular cell adenomas (2.9%), uterine endometrial stromal polyps (2.6%), adrenal cortical adenomas (1.9%), malignant lymphoma lymphocytic (1.6%), fibromas in the skin (1.3%), and pancreatic islet cell adenoma (1.1%). Metastases were observed from pheochromocytomas, hepatocellular carcinomas, nephroblastomas, renal pelvis transitional cell carcinoma, interstitial cell tumor and seminoma of the testes, Zymbal's gland adenocarcinomas, and mammary adenocarcinomas.

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Crossref · 10.1007/bf01970675

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36 of 36 references verified0 citation errors · 0 not checkable

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  • All treatments in both sexes enhanced large tumor incidence by 2-3-fold in comparison to controls, and also the number of mammary tumors in comparison to the same Harlan Sprague Dawley strain, and overall around 3-fold in comparison to the largest study with 1329 Sprague Dawley female rats.

    “All treatments in both sexes enhanced large tumor incidence by 2-3-fold in com- parison to our controls but also for the number of mammary tumors in comparison to the same Harlan Sprague Dawley strain (Brix et al., 2005), and overall around 3-fold in comparison to the largest study with 1329 Sprague Dawley female rats (Chandra et al., 1992).”
  • All treatments in both sexes enhanced large tumor incidence by two- to threefold in comparison to controls and also the number of mammary tumors in comparison to the Harlan Sprague-Dawley strain and overall around threefold in comparison to the largest study with 1,329 Sprague-Dawley female rats.

    “All treatments in both sexes enhanced large tumor incidence by two- to threefold in comparison to our controls and also the number of mammary tumors in comparison to the Harlan Sprague-Dawley strain [56] and overall around threefold in comparison to the largest study with 1,329 Sprague-Dawley female rats [57].”

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Authors
Chandra, M., Riley, M. G. I., & Johnson, D. E.
Venue
Archives of Toxicology
Published
1992-08
Volume
66
Issue
7
Pages
496-502
ISSN
  • 0340-5761 (ISSN-L)
  • 1432-0738
OpenAlex
W2081611632
Cited by
117
References
37
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 7
FWCI
1.71
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Veterinary Oncology Research
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
spontaneous neoplasms, tumor incidence, mammary tumors, pheochromocytoma, keratoacanthoma, pancreatic islet cell adenoma, adrenal adenoma, lymphoma, metastasis
MeSH terms
Adenoma, Aging, Animals, Bone Neoplasms, Brain Neoplasms, Digestive System Neoplasms, Disease Models, Animal, Female, Kidney Neoplasms, Male, Neoplasms, Pituitary Gland, Anterior, Pituitary Neoplasms, Respiratory Tract Neoplasms, Rodent Diseases, Spinal Cord Neoplasms, Testicular Neoplasms, Mammary Neoplasms, Animal, Incidence, Endometrial Neoplasms, Rats, Sprague-Dawley, Rats

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