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Cited by 96Gastroesophageal reflux and treatmentsHelicobacter pylori-related gastroenterology studiesInflammatory mediators and NSAID effects

Omeprazole produces parietal cell hypertrophy and hyperplasia in humans

Driman, David K., Wright, Cheryl, Tougas, Gervais, Riddell, Robert H.·1996·Digestive Diseases and Sciences
DOI 10.1007/bf02093608
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Abstract

While there is evidence that omeprazole may induce changes in parietal cells, the effect of acid suppression on parietal cells in humans is poorly documented. This study was undertaken to evaluate the effects of omeprazole in human parietal cells over time. The light microscopic morphology of parietal cells in gastric biopsies from 17 patients on omeprazole were compared with those from 13 patients on ranitidine and 20 patients on no acid-lowering medication. Light microscopic and ultrastructural morphology of parietal cells was also evaluated in an additional 14 patients before and after omeprazole administration. Objective measurements of parietal cell height, mass and number were analyzed using analyses of variance. Electron microscopy was used to evaluate parietal cell enlargement. Twenty-five of 31 biopsies from patients on omeprazole, 1 of 13 from patients on ranitidine, and 0 of 20 from patients on neither drug showed parietal cell enlargement. Parietal cell height, mass, and number were increased in omeprazole-treated patients compared with ranitidine-treated patients and those on neither drug, and with the group also evaluated prior to beginning omeprazole treatment. Parietal cell height and mass were increased in patients on omeprazole longer than 12 months compared with biopsies from patients on the drug for less than 12 months. Resin-embedded sections and electron microscopy showed enlarged parietal cells with prominence of cytoplasmic tubulovesicles with sparse s…

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Crossref · 10.1007/bf02093608

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38 of 38 references verified0 citation errors · 0 not checkable

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  • This finding confirms the results of Driman et al (1996) who reported increased parietal cell height, mass and number in omeprazole-treated patients compared with ranitidine-treated patients.

    “Although our H2RA group is relatively small, this finding confirms the results of Driman et al (1996) who reported increased parietal cell height, mass and number in omeprazole-treated patients compared with ranitidine-treated patients.”

    From Discontinuation of proton pump inhibitors during assessment of chromogranin A levels in patients with neuroendocrine tumours (2011) · cites this paper as Driman et al, 1996

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Authors
Driman, D. K., Wright, C., Tougas, G., & Riddell, R. H.
Affiliations
McMaster University Medical Centre (CA)
ORCID
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
1996-10
Volume
41
Issue
10
Pages
2039-2047
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
DOI
10.1007/bf02093608
OpenAlex
W2055011606
Cited by
96
References
38
Citations by year
2025: 4 · 2024: 4 · 2022: 3 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 4
FWCI
6.72
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
omeprazole, parietal cell hyperplasia, gastric acid suppression, proton pump inhibitors, ranitidine, gastric histology
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Anti-Ulcer Agents, Cell Count, Humans, Hyperplasia, Hypertrophy, Middle Aged, Omeprazole, Parietal Cells, Gastric, Ranitidine, Cell Size

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