Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial
Abstract
A double-blind study was performed comparing 5 mg delta-9-tetrahydrocannabinol (THC) p.o., 50 mg codeine p.o., and placebo in a patient with spasticity and pain due to spinal cord injury. The three conditions were applied 18 times each in a randomized and balanced order. Delta-9-THC and codeine both had an analgesic effect in comparison with placebo. Only delta-9-THC showed a significant beneficial effect on spasticity. In the dosage of THC used no altered consciousness occurred.
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An early case study reported pain relief and improvement in spasticity in a patient with a spinal cord injury following oral Δ9-THC.
“An early case study reported pain relief and improvement in spasticity in a patient with a spinal cord injury following oral Δ9-THC.162”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [162]
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- Authors
- Maurer, M., Henn, V., Dittrich, A., & Hofmann, A.
- Affiliations
- University of Zurich (CH)
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 1990-09
- Volume
- 240
- Issue
- 1
- Pages
- 1-4
- ISSN
- 0003-9373 (ISSN-L)
- 0175-758X
- 1433-8491
- OpenAlex
- W1982333830
- Cited by
- 117
- References
- 11
- Citations by year
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- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Neurology › Botulinum Toxin and Related Neurological Disorders
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- delta-9-tetrahydrocannabinol, spasticity, analgesia, spinal cord injury, codeine, cannabinoids, pain management
- MeSH terms
- Adult, Double-Blind Method, Ependymoma, Humans, Male, Neurologic Examination, Pain Measurement, Paresthesia, Postoperative Complications, Spinal Cord Neoplasms, Dronabinol, Paraparesis, Tropical Spastic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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