Age-related changes in brain: I. Magnetic resonance imaging measures of temporal lobe volumes in normal subjects
Abstract
The volume of temporal lobe structures was examined in twenty-seven older (mean age of 69.2 +/- 8.3 years) and ten younger subjects (mean age of 26.1 +/- 4.1 years) using quantitative magnetic resonance imaging (MRI) methods. Multiple regression analysis, using gender, overall atrophy, and head size as covariates, showed unique contributions of age to variance in both medial and lateral temporal lobe volumes. Temporal lobe subregions that showed the strongest unique age-related reductions were the hippocampus, fusiform gyrus, and parahippocampus. These results suggest age-related reductions in temporal lobe subvolumes.
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Age-associated reductions in hippocampus volumes have been reported.
“In addition to the higher prevalence of memory problems and IGT mentioned above, age-associated reductions in hippocampus volumes have also been reported (21).”
From Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly (2003) · cites this paper as [21]
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References 17 · Cited by 48
- Authors
- Convit, A., de Leon, M. J., Hoptman, M. J., Tarshish, C., De Santi, S., & Rusinek, H.
- Affiliations
- NYU Langone Health (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Venue
- Psychiatric Quarterly
- Published
- 1995-12
- Volume
- 66
- Issue
- 4
- Pages
- 343-355
- ISSN
- 0033-2720 (ISSN-L)
- 1573-6709
- OpenAlex
- W2028795843
- Cited by
- 48
- References
- 17
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychiatric Quarterly (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh043965-07)
- U.S. Public Health Service (P30 G08051)
- National Institute on Aging (AG 12101)
- National Institute of Mental Health (MH43965)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- brain aging, temporal lobe volume, hippocampus, fusiform gyrus, parahippocampal gyrus, brain atrophy, older adults, normal aging
- MeSH terms
- Adult, Aged, Aging, Atrophy, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Temporal Lobe
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