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Cited by 95Dementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments

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Scopolamine effects on memory, language, visuospatial praxis and psychomotor speed

Flicker, Charles, Serby, Michael, Ferris, Steven H.·1990·Psychopharmacology
DOI 10.1007/bf02244414
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Abstract

Scopolamine hydrobromide was administered by subcutaneous injection to 30 young subjects in a dose of 0.22 mg/70 kg, 0.43 mg/70 kg, or 0.65 mg/70 kg. Treatment effects were compared to placebo on an extensive cognitive assessment battery. Almost all tests in the battery had been previously administered to Alzheimer's disease patients and nondemented elderly subjects. Scopolamine produced deficits on tests of verbal recall, visuospatial recall, visual recognition memory, visuospatial praxis, visuoperceptual function, and psychomotor speed. Immediate memory, language function, object sorting, and frequency of intrusion errors were unaffected. The low dose of scopolamine produced some peripheral anticholinergic signs but did not affect the cognitive measures. The results support the conclusion reached in previous studies that the cognitive profile of scopolamine-injected young subjects is more similar to that of the nondemented elderly than to that of Alzheimer's disease patients.

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  • A well-known risk with anticholinergic medications is acute impairment in specific aspects of cognition (e.g., working memory, attention, psychomotor speed), demonstrated in single dose experimental studies and cohort studies.

    “A well-known risk with anticholinergic medications is acute impairment in specific aspects of cognition (e.g., working memory, attention, psychomotor speed) which has been demonstrated in single dose experimental studies 9-12 and cohort studies.13”

    From Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study (2015) · cites this paper as [12]

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Research works printed but not linked: 46

  1. Bartus RT, Johnson HR (1976) Short term memory in the rhesus monkey: disruption from the anticholinergic scopolamine. Pharmacol Biochem Behav 5:39–40 · DOI
  2. Bartus RT, Fleming D, Johnson HR (1978) Aging in the rhesus monkey: debilitating effects on short-term memory. J Gerontol 33:858–871 · DOI
  3. Bartus RT, Dean RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction: a critical review. Science 217:408–417 · DOI · Paper page
  4. Beatty WW, Butters N, Janowsky DS (1986) Patterns of memory failure after scopolamine treatment: implications for cholinergic hypotheses of dementia. Behav Neurol Biol 45:196–211 · DOI
  5. Benton AL, Hamsher K, Varney NR, Spreen O (1983) Contributions to neuropsychological assessment. Oxford University Press, New York
  6. Caine ED, Weingartner H, Ludlow CL, Cudahy EA, Wehry S (1981) Qualitative analysis of scopolamine-induced amnesia. Psychopharmacology 74:74–80 · DOI
  7. Crook T, Gilbert JG, Ferris SH (1980) Operationalizing memory impairment for elderly persons: the Guild memory test. Psychol Rep 47:1315–1318 · DOI
  8. Davis KL, Mohs RC, Davis BM, Levy M, Rosenberg GS, Horvath TB, De Nigris Y, Ross A, Decker P, Rothpearl A (1981) Cholinomimetic agents and human memory: clinical studies in Alzheimer's disease and scopolamine dementia. In: Crook T, Gershon S (eds) Strategies for the development of an effective treatment for senile dementia. Mark Powley Associates, New Canaan
  9. Deutsch JA (1971) The cholinergic synapse and the site of memory. Science 174:788–794 · DOI
  10. Drachman DA, Leavitt J (1974) Human memory and the cholinergic system: a relationship to aging? Arch Neurol 30:113–121 · DOI
  11. Dundee JW, Pandit SK (1972) Anterograde amnesic effects of pethidine, hyoscine, and diazepam in adults. Br J Pharmacol 44:140–144 · DOI
  12. Eslinger PJ, Benton AL (1983) Visuoperceptual performances in aging and dementia: clinical and theoretical implications. J Clin Neuropsychol 5:213–220 · DOI
  13. Ferris SH, Crook T, Sathananthan G, Gershon S (1976) Reaction time as a diagnostic measure of cognitive impairment in senility. J Am Geriatr Soc 24:529–533 · DOI
  14. Ferris SH, Crook T, Clark E, McCarthy M, Rae D (1980) Facial recognition memory deficits in normal aging and senile dementia. J Gerontol 35:707–714 · DOI
  15. Flicker C, Bartus RT, Crook T, Ferris SH (1984) Effects of aging and dementia upon recent visuospatial memory. Neurobiol Aging 5:275–283 · DOI
  16. Flicker C, Ferris SH, Crook T, Bartus RT (1986a) The effects of aging and dementia on concept formation as measured on an object-sorting task. Dev Neuropsychol 2:65–72 · DOI
  17. Flicker C, Ferris SH, Crook T, Bartus RT, Reisberg B (1986b) Cognitive decline in advanced age: future directions for the psychometric differentiation of normal and pathological age changes in cognitive function. Dev Neuropsychol 2:309–322 · DOI
  18. Flicker C, Ferris SH, Crook T, Bartus RT (1987a) Implications of memory and language dysfunction in the naming deficit of senile dementia. Brain Lang 31:187–200 · DOI
  19. Flicker C, Ferris SH, Crook T, Bartus RT (1987b) A visual recognition memory test for the assessment of cognitive function in aging and dementia. Exp Aging Res 13:127–132 · DOI
  20. Flicker C, Ferris SH, Crook T, Bartus RT (1989) Impaired facial recognition memory in aging and dementia. Alzheimer Disease and Associated Disorders (in press) · DOI
  21. Fozard JL (1985) Psychology of aging — normal and pathological age differences in memory. In: Brocklehurst JC (ed) Textbook of geriatric medicine and gerontology. Churchill/Livingstone, Edinburgh
  22. Fuld PA, Katzman R, Davies P, Terry RD (1982) Intrusions as a sign of Alzheimer dementia: chemical and pathological verification. Ann Neurol 11:155–159 · DOI
  23. Ghoneim MM, Mewaldt SP (1975) Effects of diazepam and scopolamine on storage, retrieval and organizational processes in memory. Psychopharmacologia 44:257–262 · DOI
  24. Gibson GE, Peterson C, Jenden DJ (1981) Brain acetylcholine synthesis declines with senescence. Science 214:674–676 · DOI
  25. Gilbert JG, Levee RF, Catalano FL (1968) A preliminary report on a new memory scale. Percept Mot Skills 27:277–278 · DOI
  26. Gonen JY (1970) The use of Wechsler's deterioration quotient in cases of diffuse and symmetrical cerebral atrophy. J Clin Psychol 26:174–177 · DOI
  27. Kaplan E, Goodglass H, Weintraub S (1983) Boston naming test. Lea and Febiger, Philadelphia
  28. Ketchum JS, Sidell FR, Crowell EB, Aghajanian GK, Hayes AH (1973) Atropine, scopolamine, and Ditran: comparative pharmacology and antagonists in man. Psychopharmacologia 28:121–145 · DOI
  29. Lehman HE, Ban TA (1970) Psychometric tests in evaluation of brain pathology responsive to drugs. Geriatrics 25:142–147
  30. Lippa AS, Critchett DS, Ehlert F, Yamamura HI, Enna SJ, Bartus RT (1981) Age-related alterations in neurotransmitter receptors: an electrophysiological and biochemical analysis. Neurobiol Aging 2:3–8 · DOI
  31. McCarthy M, Ferris SH, Clark E, Crook T (1981) Acquisition and retention of categorized material in normal aging and senile dementia. Exp Aging Res 7:127–135 · DOI
  32. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health & Human Services Task Force on Alzheimer's disease. Neurology 34:939–944 · DOI · Paper page
  33. Mash DC, Flynn DD, Potter LT (1985) Loss of M2 muscarinic receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. Science 228:1115–1117 · DOI
  34. Mohs RC, Johns CA, Dunn DD, Sherman NA, Rosen WG, Davis KL (1986) Anticholinergic dementia as a model of Alzheimer's disease. In: Poon LW (ed) Handbook for clinical memory assessment of older adults. American Psychological Association, Washington (DC), pp 403–408 · DOI
  35. Nuotto E (1983) Psychomotor, physiological and cognitive effects of scopolamine and ephedrine in healthy man. Eur J Clin Pharmacol 24:603–609 · DOI
  36. Perry EK, Tomlinson BE, Blessed G, Bergmann K, Gibson PH, Perry RH (1978) Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br Med J 2:1457–1459 · DOI
  37. Serby M, Corwin J, Jordan B, Novatt A, Rotrosen J (1984) Side effects of scopolamine administration. Am J Psychiatry 141:1010
  38. Sherman KA, Kuster JE, Dean RL, Bartus RT, Friedman E (1981) Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments. Neurobiol Aging 2:99–104 · DOI
  39. Sim A, Sussman I (1962) Alzheimer's disease: its natural history and differential diagnosis. J Nerv Ment Dis 135:489–499 · DOI
  40. Snodgrass JG, Vanderwart M (1980) A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J Exp Psychol [Hum Learn Mem] 6:174–215 · DOI
  41. Storandt M, Botwinick J, Danziger WL (1986) Longitudinal changes: patients with mild SDAT and matched healthy controls. In: Poon LW (ed) Handbook for clinical memory assessment of older adults, American Psychological Association, Washington (DC), pp 277–284 · DOI
  42. Strong RP, Hicks P, Hsu L, Bartus RT, Enna SJ (1980) Age-related alterations in the rodent brain cholinergic system and behavior. Neurobiol Aging 1:59–63 · DOI
  43. Tsui WH, Van Gelder P (1979) A general-purpose data extraction language. Behav Res Methods Instrum 11:199–204 · DOI
  44. Van Gelder P, Todd J, Tsui WH (1979) Data acquisition software for high data rate experiments. Behav Res Methods Instrum 11:192–198 · DOI
  45. Wechsler D (1955) Manual for the Wechsler Adult Intelligence Scale. Psychological Corporation, New York
  46. Whitehouse PJ, Price DL, Clark AW, Coyle JT, DeLong MR (1981) Alzheimer's disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 10:122–126 · DOI · Paper page

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Metadata

Authors
Flicker, C., Serby, M., & Ferris, S. H.
Affiliations
NYU Langone Health (US)
ORCID
Ferris, Steven H.
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1990-02
Volume
100
Issue
2
Pages
243-250
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf02244414
OpenAlex
W1971303733
Cited by
95
References
0
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2016: 3 · 2015: 2 · 2013: 1
FWCI
8.77
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH040410)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
scopolamine, cognitive effects, memory impairment, word recall, visual recognition memory, psychomotor speed, language functions, anticholinergic effects, Alzheimer's disease, non-demented elderly, young adults, dose-response relationship
MeSH terms
Adolescent, Adult, Cognition, Dose-Response Relationship, Drug, Hemodynamics, Humans, Memory, Memory, Short-Term, Parasympatholytics, Psychomotor Performance, Scopolamine, Space Perception, Speech, Visual Perception

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