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Cited by 24Pharmacogenetics and Drug MetabolismForensic Toxicology and Drug AnalysisVeterinary Pharmacology and Anesthesia

The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.

Comparative pharmacokinetics of alprazolam and lorazepam in humans and in African Green Monkeys

Friedman, H., Redmond, D. Eugene, Greenblatt, David J.·1991·Psychopharmacology
DOI 10.1007/bf02244562
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Abstract

The comparative pharmacokinetics of alprazolam and lorazepam were evaluated in African Green Monkeys and in healthy male human volunteers. Six monkeys received a single 250 micrograms/kg oral dose of alprazolam and of lorazepam on two separate occasions. Mean kinetic values for the two drugs, respectively, were: elimination half-life, 5.7 and 1.7 h; oral clearance, 5.5 and 40.2 ml/min/kg. Healthy male volunteers (n = 22) received a single 1 mg oral dose of alprazolam; another group (n = 24) received a single 2 mg oral dose of lorazepam. Mean values of elimination half-life in humans (11.5 and 12.4 h, for alprazolam and lorazepam, respectively) were substantially longer than corresponding values in the primate animal model, and human values of clearance (0.85 and 1.40 ml/min/kg) likewise were much lower. However, in humans, kinetic differences between the two drugs were much smaller than in the primate animals. Thus comparative studies of the behavioral effects of these two drugs in African Green Monkeys should utilize relative dosages that reflect the pharmacokinetic properties of the drugs in that species. Use of dosage ratios analogous to those used in humans may lead to results that cannot be extrapolated to humans.

Overview

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Registry

Crossref · 10.1007/bf02244562

Cites

20 of 20 references verified0 citation errors · 0 not checkable

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  • Species differences in subunit composition, distribution, and pharmacokinetics may exist between non-human primates and humans.

    “while receptor pharmacology is broadly comparable, species differences in subunit composition, distribution, and pharmacokinetics may exist (Atack et al., 2010; Friedman, Redmond, & Greenblatt, 1991).”

    From Pharmacological principles for safe benzodiazepine and Z-drug dose reduction (2026) · cites this paper as Friedman, Redmond, & Greenblatt, 1991

  • The PET imaging data used to model the dose-occupancy curve come from non-human primates rather than humans.

    “The PET imaging data used to model the dose-occupancy curve come from non-human primates rather than humans; while receptor pharmacology is broadly comparable, species differences in subunit composition, distribution, and pharmacokinetics may exist (Atack et al., 2010; Friedman, Redmond, & Greenblatt, 1991).”

    From Pharmacological principles for safe benzodiazepine and Z-drug dose reduction (2026) · cites this paper as Friedman, Redmond, & Greenblatt, 1991

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Metadata

Authors
Friedman, H., Redmond, D. E., & Greenblatt, D. J.
Affiliations
Tufts University (US)
ORCID
Greenblatt, David J.
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1991-05
Volume
104
Issue
1
Pages
103-105
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf02244562
OpenAlex
W1974843915
Cited by
24
References
21
Citations by year
2026: 1 · 2023: 1 · 2019: 1 · 2018: 1 · 2012: 1
FWCI
0.44
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH 34223)
  • National Institute on Drug Abuse (DA05258)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
  • Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
Keywords
alprazolam, lorazepam, pharmacokinetics, vervet monkey, human-monkey comparison, elimination half-life, oral clearance, species differences, benzodiazepines
MeSH terms
Adolescent, Adult, Alprazolam, Animals, Chlorocebus aethiops, Half-Life, Humans, Lorazepam, Male, Species Specificity

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