Dissociations in the expression of the sedative effects of triazolam
Abstract
Fifteen normal volunteers were administered 0.250, 0.375, and 0.500 mg of triazolam and placebo in a double-blind repeated measures cross-over design. Subjects demonstrated dose-dependent impairments in free recall, a test of explicit memory requiring awareness and reflection, and sedation as assessed by objective behavioral measures (the digit symbol substitution task) and subjective visual analogue scales. The sedative drug response did not account for the impairment in free recall. Differences in performance of the two tests of sedation indicated that the effect of this drug on reflective processes accounts for impairment in episodic memory and the inability to track the sedative effects of this drug at the higher doses tested in this study.
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Benzodiazepines administered after encoding can enhance memory in waking subjects, possibly by preventing encoding of new interfering information.
“Interestingly, there is rather consistent evidence that benzodiazepines administered after the encoding of information can enhance memory for this information in waking subjects, possibly by preventing the encoding of new interfering information after learning (247, 888, 1313, 1332).”
From About Sleep's Role in Memory (2013) · cites this paper as [1313]
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
- Authors
- Weingartner, H. J., Sirocco, K., Rawlings, R., Joyce, E., & Hommer, D.
- Affiliations
- National Institute on Alcohol Abuse and Alcoholism (US)
- Charing Cross Hospital (GB)
- National Institutes of Health (US)
- ORCID
- Joyce, E.
- Venue
- Psychopharmacology
- Published
- 1995-05
- Volume
- 119
- Issue
- 1
- Pages
- 27-33
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2032083307
- Cited by
- 14
- References
- 0
- Citations by year
- 2013: 2 · 2012: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- triazolam, sedative effects, free recall, declarative memory, episodic memory, reflective processes, benzodiazepines
- MeSH terms
- Administration, Oral, Animals, Dissociative Disorders, Dose-Response Relationship, Drug, Hypnotics and Sedatives, Male, Memory, Triazolam, Cross-Over Studies, Mice
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