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Cited by 60Sleep and Work-Related FatigueTraffic and Road SafetyTreatment of Major Depression

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Effects of moclobemide and mianserin on highway driving, psychometric performance and subjective parameters, relative to placebo

Ramaekers, J. G., Swijgman, H. F., O'Hanlon, J. F.·1992·Psychopharmacology
DOI 10.1007/bf02246238
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Abstract

The acute and sub-chronic effects of moclobemide and mianserin on driving and psychometric performance were compared to those of placebo in a double-blind, cross-over study involving 17 healthy volunteers. Mianserin, moclobemide and placebo were administered for 8 days. Subjects' performance was measured on days 1 and 8 of each treatment series; subjective sleep parameters, mood, and possible side-effects were recorded each treatment day on questionnaires or visual analog scales. Mianserin affected most of the performance measures, while moclobemide affected none; mianserin also impaired driving and tracking performance and decreased CFF. Whilst receiving mianserin, subjects reported depressed levels of alertness, calmness, and contentment; the quality of their sleep was unaffected, but its duration increased, together with feelings of drowsiness and fatigue during the day. No statistical interactions between the factors Drugs and (Treatment) Days were found, indicating that little pharmacological tolerance developed over time during mianserin treatment. Mianserin's sedative properties are held responsible for all performance and subjective effects of the drug. It is concluded that moclobemide 200 mg b.i.d. has no important sedative properties.

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Registry

Crossref · 10.1007/bf02246238

Cites

1 of 1 references verified0 citation errors · 0 not checkable

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This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Two trials involving moclobemide with healthy participants suggest that moclobemide has no effect on sleep, when compared to placebo or other antidepressants.

    “Two trials involving moclobemide with healthy participants ((Dingemanse et al., 1992), 450mg; (Ramaekers et al., 1992), 200mg) suggest that moclobemide has no effect on sleep, when compared to placebo or other antidepressants.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Ramaekers et al., 1992

  • The reversible MAOI moclobemide is less associated with REM sleep suppression.

    “The reversible MAOI moclobemide is less associated with REM sleep suppression, and appears not to effect sleep notably (Ramaekers et al., 1992).”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Ramaekers et al., 1992

  • Moclobemide appears not to affect sleep notably.

    “The reversible MAOI moclobemide is less associated with REM sleep suppression, and appears not to effect sleep notably (Ramaekers et al., 1992).”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Ramaekers et al., 1992

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 21

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  2. Casacchia M, Carolei A, Barba C, Frontini M, Rossi A, Meco G, Zylberman MR (1984) A placebo controlled study of the antidepressant activity of moclobemide; a new MAO-A inhibitor. Pharmacopsychiatry 17:125–125 · DOI
  3. Curran HV, Lader M (1986) The psychopharmacological effects of repeated doses of fluvoxamine, mianserin and placebo in healthy human subjects. Eur J Clin Pharmacol 29:601–607 · DOI
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  8. Jex HR, McDonnel JD, Phatak AV (1966) Critical tracking task for manual control research. IEEE Trans Hum Fac En 7:138–146 · DOI
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  11. Mattilla MJ, Liljequist R, Seppälä T (1978) Effects of amitriptyline and mianserin on psychomotor skills and memory. Br J Clin Pharmacol [suppl] 5:53–59
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  16. Paykel ES, White JL (1989) A European study of views on the use of monoamine oxidase inhibitors. Br J Psychiatry 155:9–17 · DOI
  17. Sanders AF (1986) Drugs, driving and the measurement of human performance. In: O'Hanlon JF, De Gier JJ (eds) Drugs and driving. Taylor and Francis, London
  18. Seppälä T (1977) Psychomotor skills during acute and two-week treatment with mianserin (org GB 94) and amitriptyline, and their combined effects with alcohol. Ann Clin Res 9:66–72
  19. Sternberg S (1969) Memory Scanning: mental processes revealed by reaction time experiments. Am Scientist 57:421–457
  20. Thieme (1986) Tolerability of moclobemide (Ro 11-1163) with ascending single oral doses in healthy male volunteers. Roche Research Report No. B-113'883
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Metadata

Authors
Ramaekers, J. G., Swijgman, H. F., & O'Hanlon, J. F.
Affiliations
Maastricht University (NL)
ORCID
Ramaekers, J. G.
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1992-02
Volume
106
Issue
S1
Pages
S62-S67
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf02246238
OpenAlex
W2033625070
Cited by
60
References
1
Citations by year
2025: 1 · 2022: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
6.14
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Physical Sciences › Engineering › Safety, Risk, Reliability and Quality › Traffic and Road Safety
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
moclobemide, mianserin, driving performance, psychometric performance, sedation, sleep quality, alertness, fatigue, drug tolerance, selective serotonin reuptake inhibitors, serotonin antagonists, subjective effects
MeSH terms
Adult, Attention, Automobile Driving, Benzamides, Double-Blind Method, Fatigue, Female, Flicker Fusion, Humans, Male, Mianserin, Middle Aged, Monoamine Oxidase Inhibitors, Psychomotor Performance, Reaction Time, Sleep, Sleep Stages, Moclobemide

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