Cognitive toxicity of pharmacotherapeutic agents used in social anxiety disorder

Hindmarch, I.

doi:10.1111/j.1742-1241.2009.02085.x

Cited by 61Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesSchizophrenia research and treatmentTreatment of Major Depression

Cognitive toxicity of pharmacotherapeutic agents used in social anxiety disorder

Hindmarch, I.·2009·International Journal of Clinical Practice

DOI 10.1111/j.1742-1241.2009.02085.x

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Abstract

OBJECTIVE: To compare cognitive impairment of medications used in social anxiety disorder (SAD). METHODS: Data from peer-reviewed publications (1975-2007) of controlled, crossover design, pharmacodynamic studies on SAD medications in healthy volunteers were analysed. The number of objective psychometrics for each drug/dose level at all time points after dosing, and of instances of statistically significant impairment of cognitive function, enabled calculation of drug-induced cognitive impairment. The magnitude of impairment between drugs was compared using proportional impairment ratios (PIRs). RESULTS: Olanzapine, oxazepam, lorazepam and mianserin had twice the average cognitive toxicity of other treatments. Selective serotonin reuptake inhibitors (SSRIs) impaired cognition to a lesser extent than other pharmacological groupings. There was extensive intra-class variation: fluvoxamine (PIR = 0.08) possessed little detrimental cognitive activity, whereas sertraline (PIR = 5.33) caused impairment over five times the SSRI group average. Benzodiazepines caused noticeable cognitive impairment. CONCLUSIONS: Substantial differences exist, both between and within therapeutic classes, in the behavioural toxicity of medications used for SAD.

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Authors: Hindmarch, I.
Affiliations: University of Surrey (GB)
Corresponding author: Hindmarch, I.
Venue: International Journal of Clinical Practice
Publisher: Wiley
Published: 2009-07
Volume: 63
Issue: 7
Pages: 1085-1094
ISSN: 1368-5031 (ISSN-L)
1742-1241
DOI: 10.1111/j.1742-1241.2009.02085.x
OpenAlex: W1965515292
Cited by: 61
References: 110
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 6
FWCI: 1.02
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2253 d)
Locations: International Journal of Clinical Practice (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: social anxiety disorder, cognitive impairment, pharmacotherapy, olanzapine, oxazepam, lorazepam, mianserin, selective serotonin reuptake inhibitors, sertraline, fluvoxamine, benzodiazepines, pharmacodynamics
MeSH terms: Antidepressive Agents, Benzodiazepines, Cognition Disorders, Female, Humans, Male, Phobic Disorders, Psychomotor Disorders, Anti-Anxiety Agents, Selective Serotonin Reuptake Inhibitors

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Cognitive toxicity of pharmacotherapeutic agents used in social anxiety disorder

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