Inhibition of REM sleep by ipsapirone, A 5HT1A agonist, in normal volunteers
Abstract
In order to test the hypothesis that serotonergic mechanisms inhibit REM sleep via a 5HT1A receptor, we administered placebo and ipsapirone (10 and 20 mg by mouth 15 min before bedtime) to ten normal volunteers in a double blind fashion. Ipsapirone is a relatively selective 5HT1A receptor agonist. As predicted, ipsapirone prolonged REM latency and Mean Latency to Eye Movements (M-LEM), a measure of time between onset of REM sleep and the first eye movement of the REM period, and REM% at both doses compared with placebo. It also reduced sleep efficiency and total REM sleep time at the highest dose. These results support the hypothesis that systemic stimulation of 5HT1A receptors prolong REM latency and inhibit REM sleep.
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Activation of 5-HT1A receptors is probably responsible for REM suppression.
“Activation of 5-HT1A receptors is probably responsible for REM suppression (Gillin et al., 1994), but is unlikely to mediate sleep fragmentation.”
From Antidepressants and their effect on sleep (2005) · cites this paper as Gillin et al., 1994
Activation of 5-HT1A receptors is unlikely to mediate sleep fragmentation.
“Activation of 5-HT1A receptors is probably responsible for REM suppression (Gillin et al., 1994), but is unlikely to mediate sleep fragmentation.”
From Antidepressants and their effect on sleep (2005) · cites this paper as Gillin et al., 1994
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Mayers, A. G., & Baldwin, D. S. (2005) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.726 · Cited by 323 · see citing works
Bhatti, T., Gillin, J. C., Seifritz, E., Moore, P., Clark, C., Golshan, S., Stahl, S., Rapaport, M., & Kelsoe, J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)80252-1 · Cited by 85 · see citing works
Self-citationRao, U., McGinty, D. J., Shinde, A., McCracken, J. T., & Poland, R. E. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00036-6 · Cited by 39 · see citing works
- Authors
- Gillin, J. C., Jernajczyk, W., Valladares-Neto, D. D. C., Golshan, S., Lardon, M., & Stahl, S. M.
- Venue
- Psychopharmacology
- Published
- 1994-12
- Volume
- 116
- Issue
- 4
- Pages
- 433-436
- ISSN
- 0033-3158
- 1432-2072
- Cited by
- 35
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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