Chronic use of benzodiazepines and cognitive deficit complaints: A risk factor study
Abstract
Benzodiazepines produce an anterograde amnesia after acute administration but whether their chronic use is hazardous to memory processes remains unclear. The present study analyses the risk of increasing cognitive complaints with chronic benzodiazepine use. Subjects seeking medical assistance at the General Internal Medicine Outpatient Clinic of Hospital de Clinicas de Porto Alegre, were interviewed before seeing physicians. They were asked about use of benzodiazepines, history of neurological and psychiatric diseases, use of alcohol, and deficits in remembering and learning as well as age, sex and level of education. Age (over 51 years), low level of education, a history of neurological and psychiatric diseases and use of benzodiazepines showed significant associations with cognitive complaints. After a conditional logistic regression analysis, benzodiazepine use lost its association with memory complaints. These data support the hypothesis that the chronic use of benzodiazepines does not carry a risk for cognitive deficits complaints.
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Research into the residual cognitive effects after long-term benzodiazepine use yields conflicting results.
“However, research into the residual cognitive effects after long-term use yields conflicting results.”
From Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: a meta-analysis (2004) · cites this paper as Chaves, Bianchin, Peccin, & Rotta, 1993
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- Authors
- Chaves, M. L. F., Bianchin, M., Peccin, S., Rotta, F., Jardim, C., Gianlupi, A., & Eidt, L.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Venue
- The Italian Journal of Neurological Sciences
- Published
- 1993-09
- Volume
- 14
- Issue
- 6
- Pages
- 429-435
- ISSN
- 1590-1874 (ISSN-L)
- 0392-0461
- 1590-3478
- OpenAlex
- W2000227652
- Cited by
- 9
- References
- 32
- Citations by year
- 2019: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- benzodiazepines, chronic benzodiazepine use, cognitive complaints, memory impairment, learning deficits, anterograde amnesia, risk factors, age, educational attainment, alcohol consumption
- MeSH terms
- Adult, Age Factors, Mental Disorders, Benzodiazepines, Cognition Disorders, Educational Status, Female, Humans, Male, Middle Aged, Risk Factors, Time Factors, Anti-Anxiety Agents, Prevalence
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