The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Lipid oxidation: Mechanisms, products and biological significance
Abstract
This paper reviews our studies of fatty acid hydroperoxides, their secondary products and mechanisms for their formation in the context of some of their possible biological consequences. The uneven distribution of isomeric hydroperoxides in oxidized linolenate and photosensitized oxidized linoleate is related to the formation of hydroperoxy cyclic peroxides. Interest in the hydroperoxy mono‐and bi‐cycloendoperoxides from oxidized linolenate stems from their structural relationship to the prostaglandins. However, the biological activity of hydroperoxy cyclic peroxides formed by autoxidation has not yet been reported. Thermal decomposition studies of secondary lipid oxidation products show they are important precursors of volatile compounds. An acid‐acetalation decomposition procedure establishes that 5‐membered hydroperoxy cyclic peroxides and 1,3‐dihydroperoxides are important precursors of malonaldehyde. This approach provides a more specific test than the thiobarbituric acid (TBA) color reaction to evaluate lipid oxidation products as sources of malonaldehyde and its biological effects due to crosslinking. A better understanding is needed of the biological effects of a multitude of lipid oxidation decomposition products other than malonaldehyde.
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Cites
Determination of malonaldehyde precursor in tissues by thiobarbituric acid test
Uchiyama, M., & Mihara, M. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90342-1 · Cited by 5,188
Pryor, W. A. (1976) · Cited by 1,876
Volatile lipid oxidation products
Frankel, E. N. (1983) · Progress in Lipid Research · doi:10.1016/0163-7827(83)90002-4 · Cited by 762
Self-citationFrankel, E. N. (1980) · Progress in Lipid Research · doi:10.1016/0163-7827(80)90006-5 · Cited by 653
Self-citationPryor, W. A., Stanley, J. P., & Blair, E. (1976) · Lipids · doi:10.1007/bf02532843 · Cited by 503
Autoxidation in Food and Biological Systems
(1980) · Springer eBooks · doi:10.1007/978-1-4757-9351-2 · Cited by 490
Lipid hydroperoxide reactivity with proteins and amino acids: a review
Gardner, H. W. (1979) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60222a034 · Cited by 421
Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde
Chio, K. S., & Tappel, A. L. (1969) · Biochemistry · doi:10.1021/bi00835a020 · Cited by 395
Mutagenicity of Malonaldehyde, a Decomposition Product of Peroxidized Polyunsaturated Fatty Acids
Mukai, F. H., & Goldstein, B. D. (1976) · Science · doi:10.1126/science.766187 · Cited by 353
Cited by
Oxidation of Polyunsaturated Fatty Acids: Mechanisms, Products, and Inhibition with Emphasis on Fish
Hsieh, R. J., & Kinsella, J. E. (1989) · Advances in Food and Nutrition Research · doi:10.1016/s1043-4526(08)60129-1 · Cited by 366
Läubli, M. W., & Bruttel, P. A. (1986) · Journal of the American Oil Chemists' Society · doi:10.1007/bf02541966 · Cited by 351
Mitochondria: Are they causal players in cellular senescence?
Correia-Melo, C., & Passos, J. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.017 · Cited by 160
Leung, K. L., Sanchita, S., Pham, C. T., Davis, B. A., Okhovat, M., Ding, X., Dumesic, P., Grogan, T. R., Williams, K. J., Morselli, M., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00970-x · Cited by 33
Metadata
- Authors
- Frankel, E. N.
- Venue
- Journal of the American Oil Chemists' Society
- Publisher
- Wiley
- Published
- 1984-12
- Volume
- 61
- Issue
- 12
- Pages
- 1908-1917
- ISSN
- 0003-021X (ISSN-L)
- 1558-9331
- OpenAlex
- W2082989058
- Cited by
- 532
- References
- 39
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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