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Mutagenicity of Malonaldehyde, a Decomposition Product of Peroxidized Polyunsaturated Fatty Acids
Abstract
Incubation of histidine requiring auxotrophs of the bacterium Salmonella typhimurium with malonaldehyde, a three-carbon dialdehyde, produced an increased number of revertants in specific strains. Mutagenesis was only observed in frameshift mutants with normal excision repair and did not occur in those base-pair substitution mutants tested. The results are consistent with the cross-linking of bacterial DNA by malonaldehyde leading to mutagenesis expressed through the error-prone repair system.
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Cited by
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672
Naturally occurring carbonyl compounds are mutagens Salmonella tester strain TA104
J. Marnett, L., Hurd, H. K., Hollstein, M. C., Levin, D. E., Esterbauer, H., & Ames, B. N. (1985) · Mutation Research · doi:10.1016/0027-5107(85)90204-0 · Cited by 586
Breast Tissue Composition and Susceptibility to Breast Cancer
Boyd, N. F., Martin, L. J., Bronskill, M., Yaffe, M. J., Duric, N., & Minkin, S. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq239 · Cited by 478
Chemistry of free radical and singlet oxidation of lipids
Frankel, E. N. (1984) · Progress in Lipid Research · doi:10.1016/0163-7827(84)90011-0 · Cited by 462
Interaction of lipid peroxidation products with DNA. A review
Vaca, C. E., Wilhelm, J., & Harms-Ringdahl, M. (1988) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(88)90022-x · Cited by 448
Metadata
- Authors
- Mukai, F. H., & Goldstein, B. D.
- Venue
- Science
- Published
- 1976-02-27
- Volume
- 191
- Issue
- 4229
- Pages
- 868-869
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2095006894
- Cited by
- 353
- References
- 0
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mutagenicity of Malonaldehyde, a Decomposition Product of Peroxidized Polyunsaturated Fatty Acids. https://app.cochat.ai/papers/10.1126/science.766187
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- Mukai, F. H., & Goldstein, B. D. (1976). Mutagenicity of Malonaldehyde, a Decomposition Product of Peroxidized Polyunsaturated Fatty Acids. Science. https://doi.org/10.1126/science.766187
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
