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Cited by 35Urinary Tract Infections ManagementPediatric Urology and Nephrology StudiesUrinary Bladder and Prostate Research

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Synergistic effect of promethazine with gentamycin in frequently recurring pyelonephritis

Molnár, J., Haszon, I., Bodrogi, T., Martonyi, E., Turi, S.·1990·International Urology and Nephrology
DOI 10.1007/bf02549770
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Abstract

The effects of promethazine were studied in children with frequently recurring pyelonephritis which was not associated with urological abnormalities. The results of three methods of treatment were compared: 10 children were given a combination of gentamycin and promethazine for 7 days (Group 1), 11 received gentamycin treatment alone for 10 days (Group 2), and 19 (Group 3) were on long-term oral antibiotic prophylaxis (5.6 +/- 2.1 years) with episodes of intensive treatment of recurrences. In a 3-year follow-up period, the number of pyelonephritis recurrences was significantly lower in Group 1 than in Groups 2 and 3. Six out of 19 children in Group 3 had renal scarring. The authors suggest a synergistic effect between gentamycin and promethazine therapy. Promethazine increases antibiotic sensitivity, which could contribute to the elimination of recurring urinary tract infections.

Overview

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Registry

Crossref · 10.1007/bf02549770

Cites

11 of 11 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 11 references

Research works printed but not linked: 5

  1. Katsilabros, Pr. L., Katsilabros, N. L.: The entrance of antibiotics into the cells with the help of chlorpromazine.Proc. Int. Congr. Chemother., VI, 1040 (1970).
  2. Molnár, J., Domonkos, K., Mándi, Y., Földeák, S., Holland, I. B.: The possible mechanism of plasmid elimination by phenothiazines and related drugs. In: Usdin, Eckert, Forrest (eds): Phenothiazines and Structurally Related Drugs: Basic and Clinical Studies. Elsevier North Holland, Inc., Amsterdam 1980, pp. 115–118.
  3. Molnár, J., Mucsi, I., Kása, P.: Inhibition of the adhesion ofE. coli cells in the presence of promethazine or imipramine.Zentralbl. Bakteriol. [Orig. A],254, 388 (1983).
  4. Molnár, J.: Antibacterial effect and elimination of plasmid multiplication by phenothiazines and related compounds (in Hung.). D.Sc. Thesis at the Hungarian Academy of Sciences, Budapest 1986.
  5. Molnár, J.: A new approach to overcome bacterial resistance to antibiotics.Drug News and Perspectives, 1, 1 (1988).

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Metadata

Authors
Molnár, J., Haszon, I., Bodrogi, T., Martonyi, E., & Turi, S.
Affiliations
University of Szeged (HU)
ORCID
Turi, S.
Venue
International Urology and Nephrology
Publisher
Springer Science and Business Media LLC
Published
1990-09
Volume
22
Issue
5
Pages
405-411
ISSN
  • 0301-1623 (ISSN-L)
  • 1573-2584
DOI
10.1007/bf02549770
OpenAlex
W2006923708
Cited by
35
References
11
Citations by year
2026: 2 · 2025: 1 · 2021: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2014: 1 · 2012: 1
FWCI
0.36
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • International Urology and Nephrology (publishedVersion)
  • PubMed (publishedVersion)
  • SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion)
Topics
  • Health Sciences › Medicine › Urology › Urinary Tract Infections Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Urology and Nephrology Studies
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
promethazine, gentamicin, recurrent pyelonephritis, urinary tract infection, antibiotic prophylaxis, drug synergy, children, renal scarring, antibiotic susceptibility
MeSH terms
Adolescent, Child, Child, Preschool, Drug Synergism, Drug Therapy, Combination, Female, Gentamicins, Humans, Male, Promethazine, Pyelonephritis, Recurrence

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.