The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Synergistic effect of promethazine with gentamycin in frequently recurring pyelonephritis
Abstract
The effects of promethazine were studied in children with frequently recurring pyelonephritis which was not associated with urological abnormalities. The results of three methods of treatment were compared: 10 children were given a combination of gentamycin and promethazine for 7 days (Group 1), 11 received gentamycin treatment alone for 10 days (Group 2), and 19 (Group 3) were on long-term oral antibiotic prophylaxis (5.6 +/- 2.1 years) with episodes of intensive treatment of recurrences. In a 3-year follow-up period, the number of pyelonephritis recurrences was significantly lower in Group 1 than in Groups 2 and 3. Six out of 19 children in Group 3 had renal scarring. The authors suggest a synergistic effect between gentamycin and promethazine therapy. Promethazine increases antibiotic sensitivity, which could contribute to the elimination of recurring urinary tract infections.
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“This action has been confirmed in a clinical study where promethazine was shown to exert a synergistic effect when combined with gentamycin in children with frequently recurring pyelonephritis (Molnar et al., 1990).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Molnar et al., 1990
Citations
Cites
Antibacterial effect of some phenothiazine compounds and R-factor elimination by chlorpromazine.
Molnár, J., Mándi, Y., & Király, J. (1976) · PubMed · Cited by 56
Self-citationThe antibacterial action and R-factor-inhibiting activity by chlorpromazine
Molnár, J., Király, J., & Mándi, Y. (1975) · Cellular and Molecular Life Sciences · doi:10.1007/bf02026369 · Cited by 31
Self-citationTetracycline Fluorescence in Permeability Studies of Membranes around Intracellular Parasites
du Buy, H. G., Riley, F. L., & Showacre, J. L. (1964) · Science · doi:10.1126/science.145.3628.163 · Cited by 20
Labedan, B. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.1.153 · Cited by 18
Effect of chlorpromazine on conjugal plasmid transfer and sex pili.
Mándi, Y., & Molnár, J. (1981) · PubMed · Cited by 14
Self-citationEffect of chlorpromazine on the ultrastructure of Staphylococcus aureus.
Kristiansen, J. E., & Blom, J. (1981) · PubMed · Cited by 13
Synergistic Effects of Chlorpromazine and Perphenazine on Several Chemotherapeutic Agents
Yamabe, S. (2009) · Chemotherapy · doi:10.1159/000237764 · Cited by 13
[Are chlorpromazine and other phenothiazines also antibiotics?].
Kristiansen, J. E. (1981) · PubMed · Cited by 9
Molnár, J., Mucsi, I., & Kása, P. (1983) · Zentralblatt für Bakteriologie Mikrobiologie und Hygiene 1 Abt Originale A Medizinische Mikrobiologie Infektionskrankheiten und Parasitologie · doi:10.1016/s0174-3031(83)80120-6 · Cited by 9
Self-citationAdhesion properties of E. coli cells in the presence of promethazine
Molnar, J. A., Csiszár, K., Czirók, E., & Szöllösy, E. (1987) · Zentralblatt für Bakteriologie Mikrobiologie und Hygiene Series A Medical Microbiology Infectious Diseases Virology Parasitology · doi:10.1016/s0176-6724(87)80041-x · Cited by 4
Research works printed but not linked: 5
- Katsilabros, Pr. L., Katsilabros, N. L.: The entrance of antibiotics into the cells with the help of chlorpromazine.Proc. Int. Congr. Chemother., VI, 1040 (1970).
- Molnár, J., Domonkos, K., Mándi, Y., Földeák, S., Holland, I. B.: The possible mechanism of plasmid elimination by phenothiazines and related drugs. In: Usdin, Eckert, Forrest (eds): Phenothiazines and Structurally Related Drugs: Basic and Clinical Studies. Elsevier North Holland, Inc., Amsterdam 1980, pp. 115–118.
- Molnár, J., Mucsi, I., Kása, P.: Inhibition of the adhesion ofE. coli cells in the presence of promethazine or imipramine.Zentralbl. Bakteriol. [Orig. A],254, 388 (1983).
- Molnár, J.: Antibacterial effect and elimination of plasmid multiplication by phenothiazines and related compounds (in Hung.). D.Sc. Thesis at the Hungarian Academy of Sciences, Budapest 1986.
- Molnár, J.: A new approach to overcome bacterial resistance to antibiotics.Drug News and Perspectives, 1, 1 (1988).
Cited by
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Antimicrobial and antiplasmid activities of essential oils
Schelz, Z., Molnar, J., & Hohmann, J. (2006) · Fitoterapia · doi:10.1016/j.fitote.2006.03.013 · Cited by 422
Spengler, G., Kincses, A., Gajdács, M., & Amaral, L. (2017) · Molecules · doi:10.3390/molecules22030468 · Cited by 189
The potential management of resistant infections with non-antibiotics
Kristiansen, J. E. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/40.3.319 · Cited by 170
Martins, M., Dastidar, S. G., Fanning, S., Kristiansen, J. E., Molnar, J. A., Pagès, J., Schelz, Z., Spengler, G., Viveiros, M., & Amaral, L. (2008) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2007.10.025 · Cited by 163
Metadata
- Authors
- Molnár, J., Haszon, I., Bodrogi, T., Martonyi, E., & Turi, S.
- Affiliations
- University of Szeged (HU)
- ORCID
- Turi, S.
- Venue
- International Urology and Nephrology
- Published
- 1990-09
- Volume
- 22
- Issue
- 5
- Pages
- 405-411
- ISSN
- 0301-1623 (ISSN-L)
- 1573-2584
- OpenAlex
- W2006923708
- Cited by
- 35
- References
- 11
- Citations by year
- 2026: 2 · 2025: 1 · 2021: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Urology and Nephrology (publishedVersion)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Urology › Urinary Tract Infections Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Urology and Nephrology Studies
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Keywords
- promethazine, gentamicin, recurrent pyelonephritis, urinary tract infection, antibiotic prophylaxis, drug synergy, children, renal scarring, antibiotic susceptibility
- MeSH terms
- Adolescent, Child, Child, Preschool, Drug Synergism, Drug Therapy, Combination, Female, Gentamicins, Humans, Male, Promethazine, Pyelonephritis, Recurrence
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
