Contact pH of rectal mucosa in humans and dogs
Abstract
Summary A technique to measure the pH on the surface of rectal mucosa of humans and dogs is described. The mean value for 121 normal subjects (7.9±0.067) was compared with values for groups of human subjects who had active and inactive ulcerative colitis, adenomatous polyps, or rectal carcinoma, and values for subjects who previously had had colonic resections or polypectomies. Statistically significant abnormal values were obtained in subjects with active chronic ulcerative colitis (6.9±0.175), adenomatous polyps (8.2±0.07), or rectal carcinoma (7.6±0.26) and in those subjects who had colon resection for rectal carcinoma (8.2±0.010). The lowered values for the group with active colitis and the group with rectal carcinoma were considered to be due to tissue damage. We are unable to explain the elevated values for the group with polyps and the group with previously-resected rectal carcinoma. The values in patients who had functional diarrhea or inactive colitis or who previously had had polypectomies were not statistically different from the values obtained in normal subjects. The value of the contact pH of rectal mucosa in dogs was 7.5±0.06.
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Rectal mucosal pH generally ranges from 7.2 to 7.9.
“Considering that rectal mucosal pH generally ranges from 7.2 to 7.9 (260), a low pH may be the cause of a LT4 suppository dose increase.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [260]
A low rectal pH may be the cause of an LT4 suppository dose increase.
“Considering that rectal mucosal pH generally ranges from 7.2 to 7.9 (260), a low pH may be the cause of a LT4 suppository dose increase.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [260]
Cites
CARPOMETACARPAL OSTEOARTHRITIS OF THE THUMB
Bangham, D. R., Copp, D. H., Parsons, J. A., & Robinson, C. J. (1970) · The Lancet · doi:10.1016/s0140-6736(70)92547-x · Cited by 288 · see citing works
pH STUDIES IN HUMAN MALIGNANT TUMOURS
Ashby, B. S. (1966) · The Lancet · doi:10.1016/s0140-6736(66)92598-0 · Cited by 165 · see citing works
Shorter, R. G., Spencer, R. J., & Hallenbeck, G. A. (1966) · Gut · doi:10.1136/gut.7.6.593 · Cited by 35 · see citing works
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Levothyroxine: conventional and novel drug delivery formulations.
Liu, H., Li, W., Zhang, W., Sun, S., & Chen, C. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac030 · Cited by 63 · see citing works
Hamada, Y., Masuda, K., Okubo, M., Nakasa, H., Sekine, Y., & Ishii, I. (2015) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00721 · Cited by 5 · see citing works
- Authors
- Bitterman, W., Spencer, R. J., Huizenga, K. A., & Shorter, R. G.
- Affiliations
- Mayo Clinic (US)
- Venue
- Diseases of the Colon & Rectum
- Published
- 1969-03
- Volume
- 12
- Issue
- 2
- Pages
- 96-98
- ISSN
- 0012-3706 (ISSN-L)
- OpenAlex
- W1968766448
- Cited by
- 14
- References
- 3
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diseases of the Colon & Rectum (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Keywords
- rectal mucosa, mucosal pH, ulcerative colitis, adenomatous polyps, rectal cancer, colectomy, polypectomy, dogs, functional diarrhea
- MeSH terms
- Adult, Aged, Animals, Colitis, Ulcerative, Diarrhea, Dogs, Female, Humans, Hydrogen-Ion Concentration, Intestinal Mucosa, Intestinal Polyps, Male, Middle Aged, Rectal Diseases, Rectal Neoplasms, Rectum
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