Studies on brain sterols in normal and pathological conditions
Abstract
Desmosterol (24‐dehydrocholesterol), a normal constituent of developing brain, rapidly disappears during the prenatal and postnatal development, according to the degree of maturation, in all species considered (chicken, mouse, rat, guinea pig, man). During brain maturation, desmosterol concentrations are sensitive to treatments with drugs interfering with sterol synthesis (Triparanol) or with nervous tissue differentiation (thyroxine and propylthiouracil). Desmosterol has been also detected in some experimental and human glial tumors, and the concentra. in the tumor may be specifically increased in the tumoral tissue by the administration of Triparanol.
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The values for brain cholesterol concentration in 7-day-old animals, and to some extent in 14-day-old mice, include desmosterol, an immediate precursor of cholesterol.
“Another point regarding the brain cholesterol concentration measurements is that the values for the 7-day-old animals in particular, and to some extent for the 14-day-old mice, include desmosterol, an immediate precursor of cholesterol (Paoletti et al., 1965; Sharpe and Brown, 2013).”
From Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis (2017) · cites this paper as Paoletti et al., 1965
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Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain
Lütjohann, D., Brzezinka, A., Barth, E., Abramowski, D., Staufenbiel, M., von Bergmann, K., Beyreuther, K., Multhaup, G., & Bayer, T. A. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200071-jlr200 · Cited by 158 · see citing works
Lopez, A. M., Chuang, J.-C., Posey, K. S., & Turley, S. D. (2017) · Brain Research · doi:10.1016/j.brainres.2016.10.021 · Cited by 24 · see citing works
- Authors
- Paoletti, R., Fumagalli, R., Grossi, E., & Paoletti, P.
- Affiliations
- University of Milan (IT)
- Venue
- Journal of the American Oil Chemists' Society
- Publisher
- Wiley
- Published
- 1965-05
- Volume
- 42
- Issue
- 5
- Pages
- 400-404
- ISSN
- 0003-021X (ISSN-L)
- 1558-9331
- OpenAlex
- W2023138413
- Cited by
- 48
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 1 · 2016: 1 · 2013: 1
- FWCI
- 15.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Oil Chemists Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- desmosterol, brain maturation, triparanol, sterol biosynthesis inhibition, thyroxine, propylthiouracil, glioma, brain tumors
- MeSH terms
- Brain, Brain Chemistry, Brain Neoplasms, Chemistry Techniques, Analytical, Sterols
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