Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain
Open accessAbstract
Cholesterol is implicated to play a role in Alzheimer disease pathology. Therefore, the concentrations of cholesterol, its precursors, and its degradation products in brain homogenates of aging wild-type and beta-amyloid precursor protein transgenic mice carrying the Swedish mutation (APP23) were analyzed. Among the sterols measured, lanosterol is the first common intermediate of two different pathways, which use either desmosterol or lathosterol as the predominant precursors for de novo synthesis of brain cholesterol. In young mice, cholesterol is mainly synthesized via the desmosterol pathway, while in aged mice, lathosterol is the major precursor. 24S-hydroxycholesterol (cerebrosterol), which plays a key role in the removal of cholesterol from the brain, modestly increased during aging. No differences in the levels of cholesterol, its precursors, or its metabolites were found between wild-type and APP23 transgenic mice. Moreover, the levels of the exogenous plant sterols campesterol and sitosterol were significantly elevated in the brains of APP23 animals at age 12 and 18 months. This time point coincides with abundant plaque formation.
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The gas chromatographic method used for cholesterol quantitation was sensitive enough to accurately determine the concentration of desmosterol only at 7 and 14 days after birth, but not of other cholesterol precursors such as lanosterol.
“The gas chromatographic method used for cholesterol quantitation was sensitive enough to accurately determine the concentration of desmosterol (only at 7 and 14 days after birth), but not of other cholesterol precursors such as lanosterol, the detection of which at any age requires methods employing gas chromatography-mass spectrometry (Lütjohann et al., 2002).”
From Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis (2017) · cites this paper as Lütjohann et al., 2002
Materials and Methods (page unavailable) says cholesterol was quantified by gas chromatography–flame ionization detection, while desmosterol and lanosterol were quantified by GC-MS. This supports the distinction between the methods used for cholesterol and its precursors, but not the claim that the cholesterol method accurately quantified desmosterol at 7 and 14 days after birth. The paper does not establish that GC-MS is required to detect lanosterol at any age. (LLM, conf=0.87)
Experimental — accuracy not yet measuredDesmosterol, lathosterol and lanosterol have been detected in the brains of mice over a wide age range.
“These three non-cholesterol sterols have been detected in the brains of mice over a wide age range (Lütjohann et al., 2002).”
From Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis (2017) · cites this paper as Lütjohann et al., 2002
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Self-citationKaru, K., Hornshaw, M. P., Woffendin, G., Bodin, K., Hámberg, M., Alvélius, G., Sjövall, J., Turton, J. A., Wang, Y., & Griffiths, W. J. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600497-jlr200 · Cited by 116 · see citing works
Analysis of oxysterols by electrospray tandem mass spectrometry
Griffiths, W. J., Wang, Y., Alvélius, G., Liu, S., Bodin, K., & Sjövall, J. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.10.012 · Cited by 115 · see citing works
Reductions in cholesterol and synaptic markers in association cortex in mood disorders
Beasley, C. L., Honer, W. G., von Bergmann, K., Falkai, P., Lütjohann, D., & Bayer, T. A. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00239.x · Cited by 112 · see citing works
Self-citationWouters, K., van Bilsen, M., van Gorp, P. J., Bieghs, V., Lütjohann, D., Kerksiek, A., Staels, B., Hofker, M. H., & Shiri-Sverdlov, R. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.046 · Cited by 109 · see citing works
Self-citationCholesterol synthesis rate in human hippocampus declines with aging
Thelen, K. M., Falkai, P., Bayer, T. A., & Lütjohann, D. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.034 · Cited by 107 · see citing works
Self-citationDietary plant sterols accumulate in the brain
Jansen, P. J., Lütjohann, D., Abildayeva, K., Vanmierlo, T., Plösch, T., Plat, J., von Bergmann, K., Groen, A. K., Ramaekers, F. C. S., Kuipers, F., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.03.015 · Cited by 103 · see citing works
Self-citationShi, C., Wu, F., Zhu, X., & Xu, J. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.12.012 · Cited by 101 · see citing works
Polymorphisms in glutathione S -transferase omega-1 and AD, vascular dementia, and stroke
Kölsch, H., Linnebank, M., Lütjohann, D., Jessen, F., Wüllner, U., Harbrecht, U., Thelen, K., Kreis, M., Hentschel, F., Schulz, A., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000147294.29309.47 · Cited by 100 · see citing works
Self-citationABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile
Langheim, S., Yu, L., von Bergmann, K., Lütjohann, D., Xu, F., Hobbs, H. H., & Cohen, J. C. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500115-jlr200 · Cited by 96 · see citing works
Self-citationBogie, J. F. J., Hoeks, C., Schepers, M., Tiane, A., Cuypers, A., Leijten, F. P. J., Chintapakorn, Y., Suttiyut, T., Pornpakakul, S., Struik, D., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41399-4 · Cited by 92 · see citing works
Self-citationAnacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects
Millar, J. S., Reyes‐Soffer, G., Jumes, P. A., Dunbar, R. L., deGoma, E. M., Baer, A. L., Karmally, W., Donovan, D. S., Rafeek, H., Pollan, L. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80025 · Cited by 88 · see citing works
Fransen, H. P., de Jong, N., Wolfs, M. C. J., Verhagen, H., Verschuren, W. M. M., Lütjohann, D., von Bergmann, K., Plat, J., & Mensink, R. P. (2007) · Journal of Nutrition · doi:10.1093/jn/137.5.1301 · Cited by 87 · see citing works
Self-citationAnalysis of neurosterols by GC–MS and LC–MS/MS
Griffiths, W. J., & Wang, Y. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.05.017 · Cited by 77 · see citing works
Methodological considerations for the harmonization of non-cholesterol sterol bio-analysis
MacKay, D., Jones, P. J. H., Myrie, S. B., Plat, J., & Lütjohann, D. (2014) · Journal of Chromatography B · doi:10.1016/j.jchromb.2014.02.052 · Cited by 76 · see citing works
Self-citationBaardman, M. E., Erwich, J. J., Berger, R. M. F., Hofstra, R. M. W., Kerstjens‐Frederikse, W. S., Lütjohann, D., & Plösch, T. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.06.003 · Cited by 75 · see citing works
Self-citationBrain sterol dysregulation in sporadic AD and MCI: relationship to heme oxygenase‐1
Hascalovici, J., Vaya, J., Khatib, S., Holcroft, C., Zukor, H., Song, W., Arvanitakis, Z., Bennett, D. A., & Schipper, H. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06213.x · Cited by 72 · see citing works
Kariv-Inbal, Z., Yacobson, S., Berkecz, R., Péter, M., Janáky, T., Lütjohann, D., Broersen, L., Hartmann, T., & Michaelson, D. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-111265 · Cited by 70 · see citing works
Self-citationBarrier, L., Ingrand, S. S., Damjanac, M., Bilan, A. R., Hugon, J., & Page, G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.002 · Cited by 68 · see citing works
Lütjohann, D., von Bergmann, K., Sirah, W., Macdonell, G., Johnson‐Levonas, A. O., Shah, A. K., Lin, J., Sapre, A., & Musliner, T. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01841.x · Cited by 67 · see citing works
Self-citationBurgess, B. L., Parkinson, P. F., Racke, M. M., Hirsch‐Reinshagen, V., Fan, J., Wong, C. A., Stukas, S. K., Théroux, L., Chan, J. Y., Donkin, J. J., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m700481-jlr200 · Cited by 65 · see citing works
Self-citationBakan, E., Yıldırım, A., Kurtul, N., Polat, M., Dursun, H., & Cayir, K. (2006) · Acta Diabetologica · doi:10.1007/s00592-007-0224-4 · Cited by 63 · see citing works
Dam, D. V., Vloeberghs, E., Abramowski, D., Staufenbiel, M., & Deyn, P. P. D. (2005) · CNS Spectrums · doi:10.1017/s1092852900010051 · Cited by 63 · see citing works
Self-citationCholesterol metabolism in the brain: importance of 24S-hydroxylation
Lütjohann, D. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00683.x · Cited by 62 · see citing works
Self-citationA Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
Wiesmann, M., Zerbi, V., Jansen, D., Haast, R., Lütjohann, D., Broersen, L. M., Heerschap, A., & Kiliaan, A. J. (2016) · Neural Plasticity · doi:10.1155/2016/6846721 · Cited by 60 · see citing works
Self-citationLi, T., Yin, Y., Zhou, Z., Qiu, J., Liu, W., Zhang, X., He, K., Cai, Y. A., & Zhu, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-24672-x · Cited by 59 · see citing works
Changes in Brain Cholesterol Metabolome After Excitotoxicity
Ong, W., Kim, J., He, X., Chen, P., Farooqui, A. A., & Jenner, A. M. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8099-3 · Cited by 57 · see citing works
Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1
Goyal, S., Xiao, Y., Porter, N. A., Xu, L., & Guengerich, F. P. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m051508 · Cited by 56 · see citing works
Analysis of bioactive oxysterols in newborn mouse brain by LC/MS
Meljon, A., Theofilopoulos, S., Shackleton, C. H. L., Watson, G. L., Javitt, N. B., Knölker, H., Saini, R., Arenas, E., Wang, Y., & Griffiths, W. J. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d028233 · Cited by 56 · see citing works
Secretion of Sterols and the NPC2 Protein from Primary Astrocytes
Mutka, A.-L., Lusa, S., Linder, M. D., Jokitalo, E., Kopra, O., Jauhiainen, M., & Ikonen, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405345200 · Cited by 56 · see citing works
Plasma lipoprotein β-amyloid in subjects with Alzheimer's disease or mild cognitive impairment
Mamo, J. C. L., Jian, L., James, A. P., Flicker, L. A., Esselmann, H., & Wiltfang, J. (2008) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2008.007214 · Cited by 52 · see citing works
Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice
Wiesmann, M., Zerbi, V., Jansen, D., Lütjohann, D., Veltien, A. A., Heerschap, A., & Kiliaan, A. J. (2017) · Theranostics · doi:10.7150/thno.18509 · Cited by 52 · see citing works
Self-citationClement, A. B., Gamerdinger, M., Tamboli, I. Y., Lütjohann, D., Walter, J., Greeve, I., Gimpl, G., & Behl, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06360.x · Cited by 53 · see citing works
Self-citationZarrouk, A., Hammouda, S., Ghzaiel, I., Hammami, S. O., Khamlaoui, W., Ahmed, S. H., Lizard, G., & Hammami, M. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666201203123046 · Cited by 52 · see citing works
Sun, S., Yang, S., Mao, Y., Jia, X., & Zhang, Z. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0020-7 · Cited by 49 · see citing works
Ballantyne, C. M., Hoogeveen, R. C., Raya, J. L., Cain, V. A., Palmer, M. K., & Karlson, B. W. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.10.022 · Cited by 49 · see citing works
Jansen, D., Zerbi, V., Arnoldussen, I. A. C., Wiesmann, M., Rijpma, A., Fang, X. T., Dederen, P. J. W. C., Mutsaers, M. P. C., Broersen, L. M., Lütjohann, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075393 · Cited by 47 · see citing works
Self-citationMetabolomics and Metabolite Profiling: Past Heroes and Future Developments
Griffiths, W. J., Karu, K., Hornshaw, M. P., Woffendin, G., & Wang, Y. (2007) · European Journal of Mass Spectrometry · doi:10.1255/ejms.850 · Cited by 46 · see citing works
Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8
Yu, L., von Bergmann, K., Lütjohann, D., Hobbs, H. H., & Cohen, J. C. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500124-jlr200 · Cited by 46 · see citing works
Self-citationLusa, S., Heino, S., & Ikonen, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212503200 · Cited by 45 · see citing works
Metabolomics and metabolite profiling
Schuhmacher, R., Krska, R., Weckwerth, W., & Goodacre, R. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-6939-5 · Cited by 45 · see citing works
Active liver X receptor signaling in phagocytes in multiple sclerosis lesions
Mailleux, J., Vanmierlo, T., Bogie, J. F. J., Wouters, E., Lütjohann, D., Hendriks, J. J. A., & van Horssen, J. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458517696595 · Cited by 44 · see citing works
Self-citationTargeted lipidomic analysis of oxysterols in the embryonic central nervous system
Wang, Y., Sousa, K. M., Bodin, K., Theofilopoulos, S., Sacchetti, P., Hornshaw, M. P., Woffendin, G., Karu, K., Sjövall, J., Arenas, E., et al. (2009) · Molecular BioSystems · doi:10.1039/b819502a · Cited by 44 · see citing works
Kane, L., Moore, K. L., Lütjohann, D., Bikle, D. D., & Schwartz, J. B. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1922 · Cited by 42 · see citing works
Self-citationWhat dictates the accumulation of desmosterol in the developing brain?
Jansen, M., Wang, W., Greco, D., Bellenchi, G. C., di Porzio, U., Brown, A. J., & Ikonen, E. (2013) · The FASEB Journal · doi:10.1096/fj.12-211235 · Cited by 42 · see citing works
Analysis of neurosterols and neurosteroids by mass spectrometry
Wang, Y., Karu, K., & Griffiths, W. J. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.008 · Cited by 42 · see citing works
Vanmierlo, T., Bloks, V. W., der Zee, L. C. V. V., Rutten, K., Kerksiek, A., Friedrichs, S., Sijbrands, E. J. G., Steinbusch, H. W. M., Kuipers, F., Lütjohann, D., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1209 · Cited by 40 · see citing works
Self-citationVanmierlo, T., Rutten, K., van der Zee, L. C. V. V. –., Friedrichs, S., Bloks, V. W., Blokland, A., Ramaekers, F. C. S., Sijbrands, E. J. G., Steinbusch, H. W. M., Prickaerts, J., et al. (2011) · Plant Foods for Human Nutrition · doi:10.1007/s11130-011-0219-3 · Cited by 40 · see citing works
Self-citationAging Induces Tissue‐Specific Changes in Cholesterol Metabolism in Rat Brain and Liver
Smiljanić, K., Vanmierlo, T., Mladenović, A., Perović, M., Lončarević‐Vasiljković, N., Tešić, V., Rakić, L., Ruždijić, S., Lütjohann, D., & Kanazir, S. (2013) · Lipids · doi:10.1007/s11745-013-3836-9 · Cited by 39 · see citing works
Self-citationAlzheimer's disease: Cholesterol a menace?
Mathew, A., Yoshida, Y., Maekawa, T., & Kumar, D. S. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.06.006 · Cited by 38 · see citing works
Jaceldo‐Siegl, K., Lütjohann, D., Sirirat, R., Mashchak, A., Fraser, G. E., & Haddad, E. H. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600828 · Cited by 38 · see citing works
Self-citationBarrier, L., Ingrand, S. S., Fauconneau, B., & Page, G. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.10.011 · Cited by 37 · see citing works
24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer’s Disease
Martens, N., Schepers, M., Zhan, N., Leijten, F. P. J., Voortman, G. J., Tiane, A., Rombaut, B., Poisquet, J., van de Sande, N., Kerksiek, A., et al. (2021) · Marine Drugs · doi:10.3390/md19040190 · Cited by 35 · see citing works
Self-citationGlöckner, F., Meske, V., Lütjohann, D., & Ohm, T. G. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318212f185 · Cited by 35 · see citing works
Self-citationThe role of extracerebral cholesterol homeostasis and ApoE e4 in cognitive decline
van den Kommer, T. N., Dik, M. G., Comijs, H. C., Lütjohann, D., Lips, P. T. A. M., Jonker, C., & Deeg, D. J. H. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.019 · Cited by 34 · see citing works
Self-citationThe lipid-lowering effect of ezetimibe in pure vegetarians
Clarenbach, J. J., Reber, M., Lütjohann, D., von Bergmann, K., & Sudhop, T. (2006) · Journal of Lipid Research · doi:10.1194/jlr.p600009-jlr200 · Cited by 34 · see citing works
Self-citationLuister, A., Schött, H.-F., Husche, C., Schäfers, H., Böhm, M., Plat, J., Gräber, S., Lütjohann, D., Laufs, U., & Weingärtner, O. (2015) · Steroids · doi:10.1016/j.steroids.2015.03.011 · Cited by 33 · see citing works
Self-citationChanges in cholesterol biosynthetic and transport pathways after excitotoxicity
Kim, J., Jittiwat, J., Ong, W., Farooqui, A. A., & Jenner, A. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06449.x · Cited by 33 · see citing works
High Fibre Diets and Alzheimer’s Disease
Martins, I. J., & Fernando, W. M. A. D. B. (2014) · Food and Nutrition Sciences · doi:10.4236/fns.2014.54049 · Cited by 33 · see citing works
Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation
Levi, O., Lütjohann, D., Devir, A., von Bergmann, K., Hartmann, T., & Michaelson, D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03441.x · Cited by 39 · see citing works
Self-citationJansen, D., Zerbi, V., Janssen, C. I. F., van Rooij, D., Zinnhardt, B., Dederen, P. J. W. C., Wright, A. J., Broersen, L. M., Lütjohann, D., Heerschap, A., et al. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0606-7 · Cited by 32 · see citing works
Self-citationWeingärtner, O., Bogeski, I., Kummerow, C., Schirmer, S. H., Husche, C., Vanmierlo, T., Wagenpfeil, G., Hoth, M., Böhm, M., Lütjohann, D., et al. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.07.016 · Cited by 31 · see citing works
Self-citationGenetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man
Laaksonen, R., Thelen, K., Päivä, H., Matinheikki, J., Vesalainen, R. K., Janatuinen, T., Knuuti, J. M., Rontu, R., von Bergmann, K., Lütjohann, D., et al. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.06.007 · Cited by 31 · see citing works
Self-citationNew insights on the neuroprotective role of sterols and sex steroids: The seladin-1/DHCR24 paradigm
Peri, A., Danza, G., Benvenuti, S., Luciani, P., Deledda, C., Rosati, F., Cellai, I., & Serio, M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.006 · Cited by 30 · see citing works
Jenner, A. M., Lim, W. L. F., Ng, M. P.-E., Wenk, M. R., Shui, G., Sharman, M. J., Gandy, S., & Martins, R. N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.026 · Cited by 30 · see citing works
Fate of dietary phytosteryl/-stanyl esters: analysis of individual intact esters in human feces
Lubinus, T., Barnsteiner, A., Skurk, T., Hauner, H., & Engel, K. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0407-4 · Cited by 27 · see citing works
Tacer, K. F., Pompon, D., & Rozman, D. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.026 · Cited by 26 · see citing works
Fricke, C., Schrøder, M., Poulsen, M., von Bergmann, K., Wester, I., Knudsen, I., Mortensen, A., & Lütjohann, D. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507756532 · Cited by 26 · see citing works
Self-citationSchött, H.-F., Baumgartner, S., Husche, C., Luister, A., Friedrichs, S., Miller, C. M., McCarthy, F. O., Plat, J., Laufs, U., Weingärtner, O., et al. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.04.011 · Cited by 25 · see citing works
Self-citationLopez, A. M., Chuang, J.-C., Posey, K. S., & Turley, S. D. (2017) · Brain Research · doi:10.1016/j.brainres.2016.10.021 · Cited by 24 · see citing works
Sterol lipidomics in health and disease: Methodologies and applications
Griffiths, W. J., & Wang, Y. (2009) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.200800116 · Cited by 24 · see citing works
Matassoli, F. L., Leão, I. C., Bezerra, B. B., Pollard, R. B., Lütjohann, D., Hildreth, J. E. K., & de Arruda, L. B. (2018) · mSphere · doi:10.1128/msphere.00497-18 · Cited by 24 · see citing works
Self-citationUlbricht, C. E. (2015) · Journal of Dietary Supplements · doi:10.3109/19390211.2015.1008812 · Cited by 24 · see citing works
Schött, H.-F., Luister, A., Husche, C., Schäfers, H., Böhm, M., Plat, J., Lütjohann, D., Laufs, U., & Weingärtner, O. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.03.007 · Cited by 23 · see citing works
Self-citationApolipoprotein CI Knock-Out Mice Display Impaired Memory Functions
Berbée, J. F. P., Vanmierlo, T., Abildayeva, K., Blokland, A., Jansen, P. J., Lütjohann, D., Gautier, T., Sijbrands, E. J. G., Prickaerts, J., Hadfoune, M., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100576 · Cited by 23 · see citing works
Self-citationZhan, N., Wang, B., Martens, N., Liu, Y., Zhao, S., Voortman, G. J., van Rooij, J., Leijten, F. P. J., Vanmierlo, T., Kuipers, F., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021290 · Cited by 22 · see citing works
Self-citationSchiepers, O. J. G., de Groot, R. H. M., van Boxtel, M. P. J., Jolles, J., de Jong, A., Lütjohann, D., Plat, J., & Mensink, R. P. (2009) · Journal of Nutrition · doi:10.3945/jn.108.103721 · Cited by 22 · see citing works
Self-citationCYP46A1-dependent and independent effects of efavirenz treatment
Mast, N., El‐Darzi, N., Petrov, A. M., Li, Y., & Pikuleva, I. A. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa180 · Cited by 21 · see citing works
- Authors
- Lütjohann, D., Brzezinka, A., Barth, E., Abramowski, D., Staufenbiel, M., von Bergmann, K., Beyreuther, K., Multhaup, G., & Bayer, T. A.
- Affiliations
- University of Bonn (DE)
- Novartis (Switzerland) (CH)
- Heidelberg University (DE)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 43
- Issue
- 7
- Pages
- 1078-1085
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W1975478041
- Cited by
- 158
- References
- 59
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 6 · 2013: 9 · 2012: 8
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- cholesterol, sterols, amyloid precursor protein, APP23 transgenic mice, Alzheimer's disease, brain aging, lanosterol, desmosterol, lathosterol, 24S-hydroxycholesterol, campesterol, sitosterol, phytosterols, amyloid plaques, cholesterol biosynthesis
- MeSH terms
- Aging, Alzheimer Disease, Animals, Blood-Brain Barrier, Brain Chemistry, Cholesterol, Disease Models, Animal, Humans, Mice, Transgenic, Mutation, Phytosterols, Sterols, Blotting, Western, Molecular Structure, Amyloid beta-Protein Precursor, Transgenes, Mice
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