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Quartz-dust-induced production of reactive oxygen metabolites by human granulocytes

Hedenborg, Mikael, Klockars, Matti·1989·Lung
DOI 10.1007/bf02714927
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Abstract

We studied the effect of quartz on the production of reactive oxygen species by human polymorphonuclear leukocytes (PMN) in vitro by a chemiluminescence (CL) assay. Quartz caused a rapid dose-dependent CL response in the cells. Diamond dust used as an inert control did not stimulate the production of reactive oxygen metabolite by PMN. The quartz-induced activation of oxygen metabolism was also demonstrated by measuring oxygen consumption, nitroblue tetrazolium reduction, and superoxide and hydrogen peroxide production by PMN. Poly-vinyl-pyridine N-oxide (a quartz surface modifying agent) completely abolished the quartz-induced response, but had no effect on opsonized zymosan-induced CL response of PMN. The effect of N-acetylcysteine (a known antioxidant) was inhibitory to the CL formation induced by both quartz and opsonized zymosan. Our results are in agreement with the hypothesis that quartz-induced production of reactive oxygen metabolites is a possible mechanism by which quartz dust produces chronic inflammation and tissue injury of the lung. Agents interfering with the generation of reactive oxygen metabolites may provide a rationale for treatment of mineral-dust-induced pulmonary disease.

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Research works printed but not linked: 34

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Metadata

Authors
Hedenborg, M., & Klockars, M.
Venue
Lung
Publisher
Springer Science and Business Media LLC
Published
1989-12
Volume
167
Issue
1
Pages
23-32
ISSN
  • 0341-2040
  • 1432-1750
DOI
10.1007/bf02714927
Cited by
34
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Quartz-dust-induced production of reactive oxygen metabolites by human granulocytes. https://app.cochat.ai/papers/10.1007/bf02714927
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Hedenborg, M., & Klockars, M. (1989). Quartz-dust-induced production of reactive oxygen metabolites by human granulocytes. Lung. https://doi.org/10.1007/bf02714927