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Cited by 137Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsNeurobiology and Insect Physiology Research

Genetic mechanisms of early neurogenesis inDrosophila melanogaster

Campos-Ortega, Jose A.·1995·Molecular Neurobiology
DOI 10.1007/bf02740668
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Abstract

The neurogenic ectoderm of Drosophila melanogaster consists of the ventral neuroectoderm and the procephalic neuroectoderm. It is hypothesized that epidermal and central neural progenitor cells separate from each other in three steps: conference on the neuroectodermal cells the capability of producing neural or epidermal progenies, separation of the two classes of progenitor cells, and specification of particular types of neuroblasts and epidermoblasts. Separation of neuroblasts and epidermoblasts is controlled by proneural and neurogenic genes. Delta and Notch serve as mediators of direct protein-protein interactions. E(SPL)-C inhibits neurogenesis, creating epidermal cells. The achaete-scute complex (AS-C) controls the commitment of nonoverlapping populations of neuroblasts and leads the development of neuroectodermal cells as neuroblasts.

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Crossref · 10.1007/bf02740668

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Authors
Campos-Ortega, J. A.
Venue
Molecular Neurobiology
Publisher
Springer Science and Business Media LLC
Published
1995-04
Volume
10
Issue
2-3
Pages
75-89
ISSN
  • 0893-7648 (ISSN-L)
  • 1559-1182
DOI
10.1007/bf02740668
OpenAlex
W231822359
Cited by
137
References
0
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 6
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Molecular Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
neurogenesis, Drosophila melanogaster, neuroectoderm, neural progenitor cells, epidermal progenitor cells, neuroblasts, proneural genes, Delta-Notch signaling, achaete-scute complex
MeSH terms
Animals, Cell Differentiation, Central Nervous System, DNA-Binding Proteins, Drosophila melanogaster, Ectoderm, Hyperplasia, Membrane Proteins, Morphogenesis, Sense Organs, Stem Cells, Transcription Factors, Genes, Insect, Gene Expression Regulation, Developmental, Cell Lineage, Drosophila Proteins, Intracellular Signaling Peptides and Proteins, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Receptors, Notch

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