Exogenous shikimic acid stimulates rapamycin biosynthesis inStreptomyces hygroscopicus
Abstract
A chemically defined medium was developed which satisfies the nutritional needs of the Streptomyces hygroscopicus strain producing the immunosuppressant rapamycin. More than a doubling of rapamycin biosynthesis was observed on addition of 57 mmol/L of exogenous shikimate. The previously observed inhibition of the synthesis by phenylalanine was not reversed by shikimate.
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Rapamycin is an antibiotic produced by Streptomyces hygroscopicus.
“Rapamycin, also known as sirolimus, is an antibiotic commonly used as a potent antifungal and immunosuppressant drug produced by the soilborne actinomycete Streptomyces hygroscopicus (Fang and Demain 1995).”
From Kinetics of rapamycin production by Streptomyces hygroscopicus MTCC 4003 (2014) · cites this paper as Fang and Demain 1995
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References 16 · Cited by 26
- Authors
- Fang, A., & Demain, A. L.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- Folia Microbiologica
- Published
- 1995-12
- Volume
- 40
- Issue
- 6
- Pages
- 607-610
- ISSN
- 0015-5632 (ISSN-L)
- 1874-9356
- OpenAlex
- W2022022269
- Cited by
- 26
- References
- 16
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 6
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Folia Microbiologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- shikimic acid, Streptomyces hygroscopicus, shikimate pathway, phenylalanine inhibition, chemically defined medium, secondary metabolite regulation
- MeSH terms
- Immunosuppressive Agents, Phenylalanine, Polyenes, Shikimic Acid, Streptomyces, Sirolimus
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