Apolipoprotein E (role in lipoprotein metabolism and pathophysiology of hyperlipoproteinemia type III)
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In apoE3/2 subjects, apoE2 concentration is about 40% higher than apoE3 in VLDL, but these subjects do not develop type III hlp or demonstrate β-VLDL.
“While this occurs to a modest extent in apoE3/2 subjects (apoE2 concentration is found to be about 40% higher than apoE3 inVLDL), these subjects do not develop type III hlp or demonstrate β-VLDL (26).”
From Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma. (1993) · cites this paper as [26]
Although about 1% of the population is homozygous for apoE2(158 Arg→Cys), only a small fraction of these individuals develop hyperlipidemia, even though all possess β-VLDL.
“Furthermore, although ~1% of the population is homozygous for apoE2(158 Arg→Cys), only a small fraction of these individuals develop hyperlipidemia, even though all possess β-VLDL (8, 9).”
From Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121–127 (1989) · cites this paper as [8]
Other factors, environmental or genetic, are required for expression of type III hyperlipoproteinemia in individuals homozygous for apoE2(158 Arg→Cys).
“Therefore, not only is the mode of inheritance recessive, but other factors, environmental or genetic, are required for expression of type III hyperlipoproteinemia in these individuals (8, 9).”
From Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121–127 (1989) · cites this paper as [8]
Cites
Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563 · see citing works
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Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17972 · Cited by 575 · see citing works
Wardell, M. R., Weisgraber, K. H., Havekes, L. M., & Rall, S. C. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)30067-5 · Cited by 80 · see citing works
Fazio, S., Horie, Y., Weisgraber, K., Havekes, L., & Rall, S. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40736-9 · Cited by 23 · see citing works
- Authors
- Utermann, G.
- Affiliations
- Philipps University of Marburg (DE)
- Corresponding author
- Utermann, Gerd
- Venue
- La Ricerca in Clinica e in Laboratorio
- Published
- 1982-01
- Volume
- 12
- Issue
- 1
- Pages
- 23-33
- ISSN
- 0390-5748 (ISSN-L)
- OpenAlex
- W4205945069
- Cited by
- 23
- References
- 1
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2019: 1
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- La Ricerca in Clinica e in Laboratorio (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- apolipoprotein E
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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