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Cited by 15Aluminum toxicity and tolerance in plants and animalsHeavy Metal Exposure and ToxicityIron Metabolism and Disorders

The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.

Disturbances of morphological parameters in blood of rats orally exposed to aluminum chloride

Chmielnicka, Jadwiga, Nasiadek, Marzenna, Pínkowski, Roman, Paradowski, Marek·1994·Biological Trace Element Research
DOI 10.1007/bf02911516
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Abstract

The aim of this work was to assess changes of morphological parameters in the blood of rats after oral (po) administration of aluminum (Al), in relation to the time and the administered dose. The experiment was performed on female Wistar rats. The animals were administered aluminum chloride (100 mg Al/kg) daily for 21 d. Morphological assays: red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), iron serum concentration (Fe), MCH, MCHC, absolute corrected reticulocyte count (ACRC), white blood cells (WBC), and platelet count (PLT) were estimated on d 3, 7, 14, and 21, both in the control group and in intoxicated rats. After wk 1 of aluminum administration we observed a decrease of RBC, HCT, HGB and serum iron concentration in the blood of rats. The increase of the platelet count was observed earlier than changes in other parameters. Investigation has proved that the exposure of rats to aluminum administered orally results in normocytic anemia.

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Research works printed but not linked: 14

  1. H. L. Elliot and A. J. McDougall,Proc. Eur. Dial. Trans. Ass. 15, 157 (1978).
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Metadata

Authors
Chmielnicka, J., Nasiadek, M., Pínkowski, R., & Paradowski, M.
Affiliations
Medical University of Lodz (PL)
ORCID
Nasiadek, Marzenna
Venue
Biological Trace Element Research
Publisher
Springer Science and Business Media LLC
Published
1994-09
Volume
42
Issue
3
Pages
191-199
ISSN
  • 0163-4984 (ISSN-L)
  • 1559-0720
DOI
10.1007/bf02911516
OpenAlex
W1987247809
Cited by
15
References
39
Citations by year
2024: 2 · 2022: 1 · 2019: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Biological Trace Element Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
aluminum chloride, blood morphology, normocytic anemia, red blood cell indices, hematocrit, hemoglobin, serum iron, platelet count, reticulocyte count, dose-time relationship
MeSH terms
Aluminum Chloride, Administration, Oral, Anemia, Animals, Blood Cells, Chlorides, Disease Models, Animal, Dose-Response Relationship, Drug, Erythrocyte Count, Erythrocyte Indices, Female, Hematocrit, Hemoglobins, Iron, Leukocyte Count, Platelet Count, Rats, Wistar, Aluminum Compounds, Reticulocyte Count, Rats

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