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Cited by 66Aluminum toxicity and tolerance in plants and animalsIron Metabolism and DisordersHeavy Metal Exposure and Toxicity

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Morphologic and functional alterations of erythroid cells induced by long-term ingestion of aluminium

Vittori, Daniela, Nesse, Alcira, Pérez, Gladys, Garbossa, Graciela·1999·Journal of Inorganic Biochemistry
DOI 10.1016/s0162-0134(99)00122-1
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Abstract

Anaemia has been associated with aluminium (Al) accumulation in plasma and/or bone tissue in patients with chronic renal insufficiency. Nevertheless, in previous works, we have found shortened red-cell life span, increased osmotic resistance and inhibition of colony-forming units-erythroid (CFU-E) development in Al-overloaded rats with normal renal function. To elucidate further the action of Al on in vivo erythropoiesis, aluminium citrate was provided to Sprague Dawley rats (n = 18) in the drinking water for 8 months. Significant decreases in haematocrit (38.8 +/- 4.29 versus 43.1 +/- 3.58%, p < 0.05) and blood haemoglobin concentration (137 +/- 10.1 versus 148 +/- 8.5 g/l, p < 0.05), reticulocytosis (1.8/1.3-4.2 versus 1.2/0.4-3.7%, p < 0.05), and severe inhibition of CFU-E growth (670/120-950 versus 1530/810-2440 CFU-E/2 x 10(5) cells, p < 0.005) were found. Anysocytosis, poikilocytosis and schistocytosis were detected in peripheral blood stained films. Scanning electron microscopy revealed the presence of erythrocytes with abnormal shape, including crenated and target cells. Aluminium was localised specially inside the schistocytes by EDAX analysis. Decreased haptoglobin concentration (107/83-127 versus 139/89-169 mg/l, p < 0.05) supports the assumption of haemolytic nature of the anaemia. Rats were not iron depleted, as plasma iron concentration and total iron binding capacity were found in the range of control values, and sideroblasts and haemosiderin deposits were observed in bone marrow smears. Total 59Fe uptake and 59Fe incorporated to haem by the bone marrow cells were found decreased. In conclusion, the erythropoiesis impairment induced by Al may be a combined effect of direct action on circulating erythrocytes and interference with the cellular iron metabolism in erythroid progenitors.

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Crossref · 10.1016/s0162-0134(99)00122-1

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26 of 26 references verified0 citation errors · 0 not checkable

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  • After long-term oral intake of Al, schistocytes and target cells were observed in stained peripheral blood of rats.

    “After long-term oral intake of Al, schistocytes and target cells were observed in stained peripheral blood of rats (Vittori et al., 1999).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Vittori et al., 1999

  • Al exposure has been associated with significant inhibition of colony forming units-erythroid (CFU-E) development in the bone marrow of mice and rats exposed to Al.

    “Al exposure has been associated with significant inhibition of colony forming units-erythroid (CFU-E) development in the bone marrow of mice exposed to 13 mg Al/kg as Al citrate or chloride administered via gavage for 5 days/week for 22 weeks (Garbossa et al., 1996), rats exposed to 27 mg Al/kg as Al citrate administered via gavage 5 days/week for 15 weeks (Garbossa et al., 1998), and rats exposed”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Vittori et al., 1999

  • Significant decreases in hemoglobin, hematocrit and erythrocyte osmotic fragility were reported after Al exposure.

    “Significant decreases in hemoglobin, hematocrit (packed cell volume) and erythrocyte osmotic fragility were reported after Al exposure (Garbossa et al., 1996; Garbossa et al., 1998; Vittori et al., 1999; Farina et al., 2005).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Vittori et al., 1999

Citations

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Research works printed but not linked: 12

  1. Short, 1980, Proc. Eur. Dial. Transplant Assoc., 17, 226
  2. Montenegro, 1998, Clin. Nephrol., 50, 77
  3. Touam, 1983, Clin. Nephrol., 19, 295
  4. Drüeke, 1986, Kidney Int. (Suppl. 18), 29, S45
  5. Garbossa, 1996, Miner. Electrolyte Metab., 22, 214
  6. Zaman, 1990, Folia Histochem. Cytobiol., 28, 61
  7. Garbossa, 1994, Miner. Electrolyte Metab., 20, 141
  8. Recker, 1977, J. Lab. Clin. Med., 90, 810
  9. Udupa, 1986, Exp. Hematol., 14, 343
  10. Kennedy, 1978, Blood Cells, 4, 143
  11. J.N. Lukens, in: G.R. Lee, T.C. Bithell, J. Foerster, J.W. Athens, J.N. Lukens (Eds.), Wintrobe's Clinical Hematology, 9th edn., Lea and Febiger, Malvern, PA.
  12. G.R. Lee, in: G.R. Lee, T.C. Bithell, J. Foerster, J.W. Athens, J.N. Lukens (Eds.), Wintrobe's Clinical Hematology, 9th edn., Lea and Febiger, Malvern, PA.

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Metadata

Authors
Vittori, D., Nesse, A., Pérez, G., & Garbossa, G.
Affiliations
Universidad de Buenos Aires (AR)
Corresponding author
Garbossa, Graciela
ORCID
Vittori, Daniela
Venue
Journal of Inorganic Biochemistry
Publisher
Elsevier BV
Published
1999-08
Volume
76
Issue
2
Pages
113-120
ISSN
0162-0134 (ISSN-L)
DOI
10.1016/s0162-0134(99)00122-1
OpenAlex
W2026890404
Cited by
66
References
26
Citations by year
2024: 1 · 2022: 1 · 2020: 2 · 2019: 3 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 9 · 2012: 6
FWCI
3.57
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Inorganic Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Manchester
  • Universidad de Buenos Aires
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
aluminum toxicity, erythropoiesis, erythroid progenitor cells, CFU-E, anemia, hemolysis, reticulocytosis, schistocytes, haptoglobin, iron metabolism, sideroblasts, hemosiderin, erythrocyte morphology, aluminum citrate, chronic renal insufficiency, bone marrow
MeSH terms
Aluminum, Animals, Biological Availability, Bone Marrow Cells, Erythrocyte Deformability, Erythrocytes, Female, Hemolysis, Iron, Microscopy, Electron, Scanning, Rats, Sprague-Dawley, Rats

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