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Cited by 22Iron Metabolism and DisordersTrace Elements in HealthPlant Micronutrient Interactions and Effects

Endogenous iron excretion: A quantitative means to control iron metabolism?

Kreuzer, M., Kirchgessner, M.·1991·Biological Trace Element Research
DOI 10.1007/bf03032686
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Abstract

The effects of supplemental oral (0, 40, and 400 ppm) and parenteral iron (0 and 2.72 mg Fe iv given initially as a single dose) on iron absorption, excretion, and retention were determined in 30 rats. Endogenous fecal iron excretion was determined by the radioisotope dilution technique after im injection of 80 kBq Fe-59, using blood and certain body tissues as reference sources for the estimation of the specific activity (Bq Fe-59/micrograms Fe) of endogenous iron. The basal diet contained 3.6 ppm Fe. Fe(III)-hydroxide-polymaltose was used as the sole iron source in oral, iv, and im iron treatments. Iron balance as determined from day 14 to 20 of the experiment was not significantly affected by iv iron administration. Nevertheless, a temporarily reduced retention should have occurred, since differences in final body iron contents were lower than 2.72 mg, as compared to the respective untreated groups. Apparent iron absorption and iron retention increased with surplus oral iron, and the efficiency rates were highest with adequate iron supply (40 ppm). True absorption rates of iron were similar without any, and with 40 ppm Fe amounting 40 to 50% of the intake. In the iron deficient rats, half of the actually absorbed iron (about 16 micrograms/d) was lost by endogenous fecal re-excretion, and another 3 micrograms/d by the urinary route. Endogenous loss with feces and with urine increased with further oral iron supply, but at a considerably lower rate as total fecal excretion. Parenterally administered iron did not affect endogenous loss at all. The results indicate that endogenous excretion cannot be regarded as a means to eliminate excessive iron, and might actually be an inevitable loss.

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  • The structure of mitochondrial ferritin was determined at 1.38 angstrom resolution and is very similar to that of ferritin H, with about 80% homology in amino acid sequences.

    “The structure of mitochondrial ferritin was determined at 1.38 angstrom resolution and was very similar to that of ferritin H, with ∼80% homology in the amino acid sequences (172).”

    From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [172]

  • The functional elements of mitochondrial ferritin are similar to those of ferritin H, including ferroxidase activity and metal-binding sites.

    “The functional elements of mitochondrial ferritin are similar to those of ferritin H, including ferroxidase activity and metal-binding sites (172)”

    From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [172]

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Authors
Kreuzer, M., & Kirchgessner, M.
Affiliations
Technical University of Munich (DE)
ORCID
Kreuzer, M.
Venue
Biological Trace Element Research
Publisher
Springer Science and Business Media LLC
Published
1991-05
Volume
29
Issue
2
Pages
77-92
ISSN
  • 0163-4984 (ISSN-L)
  • 1559-0720
DOI
10.1007/bf03032686
OpenAlex
W2026543535
Cited by
22
References
39
Citations by year
2022: 2 · 2021: 1 · 2015: 1
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Biological Trace Element Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
Keywords
iron absorption, iron retention, iron balance, oral iron supplementation, iron deficiency, rats
MeSH terms
Absorption, Animals, Diet, Feces, Homeostasis, Injections, Intravenous, Iron, Male, Radioisotope Dilution Technique, Rats, Inbred Strains, Rats

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