Metabolic and cardiovascular profile in patients with Addison’s disease under conventional glucocorticoid replacement
Abstract
Objective Although two studies have shown that Addison's disease (AD) is still a potentially lethal condition for cardiovascular, malignant, and infectious diseases, a recent retrospective study showed a normal overall mortality rate. Differently from secondary hypoadrenalism, scanty data exist on the role of conventional glucocorticoid replacement on metabolic and cardiovascular outcome in AD. Subjects and methods In 38 AD under conventional glucocorticoid replacement (hydrocortisone 30 mg/day or cortisone 37.5 mg/day) ACTH, plasma renin activity (PRA), DHEAS, fasting glucose and insulin, 2-h glucose after oral glucose tolerance test, serum lipids, 24-h blood pressure and intima-media thickness (IMT) were evaluated and compared with 38 age-, sex- and body mass index (BMI)-matched controls (CS). Results AD had ACTH and PRA higher and DHEAS lower (p 190 mg/dl. At the multiple regression analysis, in both AD and CS, BMI was the best predictor of 2-h glucose and age of total and LDL cholesterol; in AD, no significant correlation was found between the above mentioned metabolic parameters and either hormone levels or disease duration. In both AD and CS 24-h blood pressure and IMT were normal. Conclusions Our study shows a higher prevalence of central adiposity, impaired glucose tolerance and dyslipidemia in AD patients.
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Patients with primary adrenal insufficiency have metabolic or cardiovascular complications including hypertension.
“There are also a number metabolic or cardiovascular complications including hypertension (167).”
From Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [167]
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BackgroundDiagnosis and management of adrenal insufficiency
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- Authors
- Giordano, R., Marzotti, S., Balbo, M., Romagnoli, S., Marinazzo, E., Berardelli, R., Migliaretti, G., Benso, A., Falorni, A., Ghigo, E., & Arvat, E.
- Affiliations
- University of Turin (IT)
- University of Perugia (IT)
- Corresponding author
- Arvat, E.
- Venue
- Journal of Endocrinological Investigation
- Published
- 2009-07-20
- Volume
- 32
- Issue
- 11
- Pages
- 917-923
- ISSN
- 0391-4097 (ISSN-L)
- 1720-8386
- OpenAlex
- W2072014838
- Cited by
- 84
- References
- 8
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 2 · 2014: 11 · 2013: 3 · 2012: 4
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Endocrinological Investigation (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- Addison's disease, glucocorticoid replacement therapy, cortisol, cortisone, abdominal obesity, impaired glucose tolerance, dyslipidemia, hypercholesterolemia, hypertriglyceridemia, plasma renin activity, ACTH, dehydroepiandrosterone sulfate, intima-media thickness, blood pressure, cardiovascular risk, metabolic profile
- MeSH terms
- Addison Disease, Adrenocorticotropic Hormone, Adult, Aged, Blood Glucose, Cardiovascular Diseases, Female, Glucocorticoids, Humans, Lipids, Male, Middle Aged, Renin, Body Mass Index, Dehydroepiandrosterone Sulfate, Waist Circumference
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