Cardiovascular risk factors and ultrasound evaluation of intima-media thickness at common carotids, carotid bulbs, and femoral and abdominal aorta arteries in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Open accessAbstract
CONTEXT: In congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, a tendency for obesity, high insulin, and high 24-h blood pressure levels has been reported in children and adolescents. Increased intima-media thickness (IMT) is considered a measure of subclinical atherosclerosis and a predictor of myocardial infarction and stroke. OBJECTIVE: The objective of the study was to evaluate glucose metabolism, lipid profile, IMT of the abdominal aorta, right and left common carotids, carotid bulbs, and common femoral arteries in adult CAH patients. SUBJECTS: Nineteen (10 females, nine males; 28 +/- 3.5 yr) patients (12 salt wasting and seven simple virilizing) and 19 (10 females, nine males) healthy subjects matched for anthropometric parameters (age, sex, body mass index, smoking habit, waist to hip ratio, and blood pressure). METHODS: Glucose metabolism was studied using the oral glucose tolerance test and the homeostasis model assessment-insulin resistance. The echo-Doppler was used for arterial ultrasound. 17-Hydroxyprogesterone, androstenedione, testosterone, ACTH, plasma renin activity, total and high-density lipoprotein cholesterol, and triglycerides were measured. RESULTS: CAH patients had significantly higher fasting plasma insulin (11.6 +/- 6.20 microU/ml vs 5.18 +/- 2.4 microU/ml; P < 0.0001) and homeostasis model assessment-insulin resistance than controls (2.46 +/- 1.92 vs 1.12 +/- 0.58; P = 0.0033). IMT of the studied arteries was higher in CAH patients than controls. There was no correlation between IMT and cumulative glucocorticoid doses and androgen levels. CONCLUSION: A reduced insulin sensitivity and increased IMT were demonstrated in adults with CAH, who consequently need a follow-up for cardiovascular risk.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There are minimal data on the prevalence of hypertension in adults with CAH, with inconsistent results in individual studies conducted in different locales.
“There are minimal data on the prevalence of hypertension in adults with CAH (679,680), with inconsistent results in individual studies conducted in different locales (626,671,681).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [680]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
O'Leary, D. H., Polak, J. F., Kronmal, R. A., Manolio, T. A., Burke, G. L., & Wolfson, S. K. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901073400103 · Cited by 4,685 · see citing works
Benefit of Carotid Endarterectomy in Patients with Symptomatic Moderate or Severe Stenosis
Barnett, H. J. M., Taylor, D. W., Eliasziw, M., Fox, A. J., Ferguson, G. G., Haynes, R. B., Rankin, R. N., Clagett, G. P., Hachinski, V., Sackett, D. L., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811123392002 · Cited by 3,596 · see citing works
Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging.
Pignoli, P., Tremoli, E., Poli, A., Oreste, P., & Paoletti, R. (1986) · Circulation · doi:10.1161/01.cir.74.6.1399 · Cited by 2,404 · see citing works
Congenital Adrenal Hyperplasia
Speiser, P., & White, P. C. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711263172211 · Cited by 1,409 · see citing works
Prevalence and Characteristics of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome
Apridonidze, T., Essah, P. A., Iuorno, M. J., & Nestler, J. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1045 · Cited by 931 · see citing works
Vogeser, M., Zachoval, R., Felbinger, T. W., Jacob, K., Radetti, G., Bona, G., Corrias, A., Cappa, M., DeSanctis, V., Lauriola, S., et al. (2002) · Hormone Research in Paediatrics · doi:10.1159/000065490 · Cited by 451 · see citing works
Adrenomedullary dysplasia and hypofunction in patients with classic 21-hydroxylase deficiency.
Merke, D. P., Chrousos, G. P., Eisenhofer, G., Weise, M., Keil, M. F., Rogol, A. D., Van Wyk, J. J., & Bornstein, S. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011093431903 · Cited by 266 · see citing works
Insulin resistance and the endothelium
Hsueh, W. A., Lyon, C. J., & Quiñones, M. J. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.02.042 · Cited by 234 · see citing works
Long Term Outcome in Adult Males with Classic Congenital Adrenal Hyperplasia1
Cabrera, M. S., Vogiatzi, M. G., & New, M. I. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7668 · Cited by 204 · see citing works
Völkl, T. M. K., Simm, D., Beier, C., & Dörr, H. G. (2006) · PEDIATRICS · doi:10.1542/peds.2005-1005 · Cited by 184 · see citing works
Cheng, K.-S. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00551-x · Cited by 173 · see citing works
Charmandari, E., Weise, M., Bornstein, S. R., Eisenhofer, G., Keil, M. F., Chrousos, G. P., & Merke, D. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8456 · Cited by 164 · see citing works
Merke, D. P., Bornstein, S. R., Avila, N. A., & Chrousos, G. P. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-4-200202190-00012 · Cited by 147 · see citing works
Stikkelbroeck, N. M. M. L., Oyen, W. J. G., van der Wilt, G.-J., Hermus, A. R. M. M., & Otten, B. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021074 · Cited by 138 · see citing works
Obesity in 21-hydroxylase deficient patients
Cornean, R. E., Hindmarsh, P. C., & Brook, C. G. D. (1998) · Archives of Disease in Childhood · doi:10.1136/adc.78.3.261 · Cited by 135 · see citing works
Roche, E. F., Charmandari, E., Dattani, M. T., & Hindmarsh, P. C. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01757.x · Cited by 113 · see citing works
Factors influencing anatomic location of fat tissue in 52,953 women.
Lanska, D. J., Lanska, M. J., Hartz, A. J., & Rimm, A. A. (1985) · PubMed · Cited by 88 · see citing works
Adrenomedullary function may predict phenotype and genotype in classic 21-hydroxylase deficiency
Charmandari, E., Eisenhofer, G., Mehlinger, S. L., Carlson, A., Wesley, R., Keil, M. F., Chrousos, G. P., New, M. I., & Merke, D. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8664 · Cited by 70 · see citing works
Long Term Outcome in Adult Males With Classic Congenital Adrenal Hyperplasia
Jarow, J. P. (2002) · The Journal of Urology · doi:10.1097/00005392-200208000-00120 · Cited by 66 · see citing works
Flagged first, then by citations
2 of the 22 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management
Claahsen - van der Grinten, H. L., Speiser, P. W., Ahmed, S. F., Arlt, W., Auchus, R. J., Falhammar, H., Flück, C. E., Guasti, L., Huebner, A., Kortmann, B. B. M., et al. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab016 · Cited by 556 · see citing works
Falhammar, H., Frisén, L., Hirschberg, A. L., Norrby, C., Almqvist, C., Nordenskjöld, A., & Nordenström, A. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2093 · Cited by 204 · see citing works
Increased mortality in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Falhammar, H., Frisén, L., Norrby, C., Hirschberg, A. L., Almqvist, C., Nordenskjöld, A., & Nordenström, A. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2957 · Cited by 196 · see citing works
Congenital Adrenal Hyperplasia
Witchel, S. F., & Azziz, R. (2011) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2010.10.001 · Cited by 147 · see citing works
Clinical perspectives in congenital adrenal hyperplasia due to 11β-hydroxylase deficiency
Bulsari, K., & Falhammar, H. (2016) · Endocrine · doi:10.1007/s12020-016-1189-x · Cited by 139 · see citing works
NonClassic Congenital Adrenal Hyperplasia
Witchel, S. F., & Azziz, R. (2010) · International Journal of Pediatric Endocrinology · doi:10.1155/2010/625105 · Cited by 132 · see citing works
Approach to the Adult with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Merke, D. P. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2417 · Cited by 128 · see citing works
Falhammar, H., & Nordenström, A. (2015) · Endocrine · doi:10.1007/s12020-015-0656-0 · Cited by 127 · see citing works
Tamhane, S., Rodriguez-Gutierrez, R., Iqbal, A. M., Prokop, L. J., Bancos, I., Speiser, P. W., & Murad, M. H. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01862 · Cited by 123 · see citing works
Health Problems in Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Reisch, N., Arlt, W., & Krone, N. P. (2011) · Hormone Research in Paediatrics · doi:10.1159/000327794 · Cited by 107 · see citing works
Testosterone and Cardiovascular Health
Elagizi, A., Köhler, T., & Lavie, C. J. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.11.006 · Cited by 106 · see citing works
Clinical outcomes in the management of congenital adrenal hyperplasia
Falhammar, H., & Thorén, M. (2012) · Endocrine · doi:10.1007/s12020-011-9591-x · Cited by 106 · see citing works
Falhammar, H., Filipsson Nyström, H., Wedell, A., & Thorén, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-0877 · Cited by 103 · see citing works
Falhammar, H., Butwicka, A., Landén, M., Lichtenstein, P., Nordenskjöld, A., Nordenström, A., & Frisén, L. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3707 · Cited by 98 · see citing works
Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease
Hadoke, P. W. F., Iqbal, J., & Walker, B. R. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00047.x · Cited by 98 · see citing works
Mooij, C. F., Kroese, J. M., Claahsen‐van der Grinten, H. L., Tack, C. J., & Hermus, A. R. M. M. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03690.x · Cited by 92 · see citing works
Riepe, F. G., & Sippell, W. G. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9053-1 · Cited by 91 · see citing works
Giordano, R., Marzotti, S., Balbo, M., Romagnoli, S., Marinazzo, E., Berardelli, R., Migliaretti, G., Benso, A., Falorni, A., Ghigo, E., et al. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03345773 · Cited by 84 · see citing works
Subbarayan, A., Dattani, M. T., Peters, C. J., & Hindmarsh, P. C. (2014) · Clinical Endocrinology · doi:10.1111/cen.12265 · Cited by 73 · see citing works
Williams, R. M., Deeb, A., Ong, K. K., Bich, W., Murgatroyd, P. R., Hughes, I. A., & Acerini, C. L. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03587.x · Cited by 68 · see citing works
Increased arterial stiffness in female‐to‐male transsexuals treated with androgen
Emi, Y., Adachi, M., Sasaki, A., Nakamura, Y., & Nakatsuka, M. (2008) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2008.00857.x · Cited by 67 · see citing works
Marra, A. M., Improda, N., Capalbo, D., Salzano, A., Arcopinto, M., De Paulis, A., Alessio, M., Lenzi, A., Isidori, A. M., Cittadini, A., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1805 · Cited by 67 · see citing works
Steroid 21 Hydroxylase Deficiency Congenital Adrenal Hyperplasia
Nimkarn, S., Lin‐Su, K., & New, M. I. (2011) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2011.07.012 · Cited by 62 · see citing works
Webb, E. A., & Krone, N. P. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.04.002 · Cited by 59 · see citing works
Adult Consequences of Congenital Adrenal Hyperplasia
Arlt, W., & Krone, N. P. (2007) · Hormone Research in Paediatrics · doi:10.1159/000110615 · Cited by 58 · see citing works
Bachelot, A., Grouthier, V., Courtillot, C., Dulon, J., & Touraine, P. A. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0888 · Cited by 55 · see citing works
Paizoni, L., Auer, M. K., Schmidt, H., Hübner, A., Bidlingmaier, M., & Reisch, N. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105540 · Cited by 53 · see citing works
Congenital adrenal hyperplasia – pharmacologic interventions from the prenatal phase to adulthood
Claahsen-van der Grinten, H. L., Stikkelbroeck, N. M. M. L., Otten, B. J., & Hermus, A. R. M. M. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.05.004 · Cited by 53 · see citing works
Steroid 21 hydroxylase deficiency congenital adrenal hyperplasia
Nimkarn, S., Lin-Su, K., & New, M. I. (2009) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.08.001 · Cited by 52 · see citing works
Long-Term Outcome of Patients With Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency
Mnif, M. F., Kamoun, M., Mnif, F., Charfi, N., Kallel, N., Naceur, B. B., Rekik, N. M., Abid, M., Mnif, Z., Sfar, M. H., et al. (2012) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31824369e4 · Cited by 49 · see citing works
Hypertension in children with congenital adrenal hyperplasia
Maccabee-Ryaboy, N., Thomas, W. T. B., Kyllo, J. H., Lteif, A. N., Petryk, A., Gonzalez‐Bolanos, M. T., Hindmarsh, P. C., & Sarafoglou, K. (2016) · Clinical Endocrinology · doi:10.1111/cen.13086 · Cited by 49 · see citing works
Harrington, J., Peña, A. S., Gent, R. J., Hirte, C., & Couper, J. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04309.x · Cited by 46 · see citing works
Stewart, P. M., & Krone, N. P. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00015-8 · Cited by 44 · see citing works
Amr, N. H., Ahmed, A. Y., & Ibrahim, Y. A. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0148-8 · Cited by 43 · see citing works
Ceccato, F., Barbot, M., Albiger, N., Zilio, M., De Toni, P., Luisetto, G., Zaninotto, M., Greggio, N. A., Boscaro, M., Scaroni, C., et al. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0104 · Cited by 42 · see citing works
Self-citationMooij, C. F., Kroese, J. M., Sweep, F. C. G. J., Hermus, A. R., & Tack, C. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024204 · Cited by 42 · see citing works
Long-Term Outcomes of Congenital Adrenal Hyperplasia
Nordenström, A., Lajić, S., & Falhammar, H. (2022) · Endocrinology and Metabolism · doi:10.3803/enm.2022.1528 · Cited by 41 · see citing works
Kim, M. S., & Merke, D. P. (2009) · Seminars in Reproductive Medicine · doi:10.1055/s-0029-1225259 · Cited by 41 · see citing works
Reisch, N. (2019) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0820-2085 · Cited by 38 · see citing works
Zimmermann, A., Grigorescu‐Sido, P., Alkhzouz, C., Patberg, K., Bucerzan, S., Schulze, E., Zimmermann, T., Rossmann, H., Geiss, H. C., Lackner, K. J., et al. (2010) · Hormone Research in Paediatrics · doi:10.1159/000313368 · Cited by 38 · see citing works
Guidelines for diagnosis and treatment of 21-hydroxylase deficiency (2014 revision)
Ishii, T., Anzo, M., Adachi, M., Onigata, K., Kusuda, S., Nagasaki, K., Harada, S., Horikawa, R., Minagawa, M., Minamitani, K., et al. (2015) · Clinical Pediatric Endocrinology · doi:10.1297/cpe.24.77 · Cited by 36 · see citing works
Wasniewska, M. G., Balsamo, A., Valenzise, M., Manganaro, A., Faggioli, G., Bombaci, S., Conti, V., Ferri, M., Aversa, T., Cicognani, A., et al. (2013) · PubMed · doi:10.3275/8194 · Cited by 36 · see citing works
Classical Forms of Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency in Adults
Bachelot, A., Chakthoura, Z., Rouxel, A., Dulon, J., & Touraine, P. A. (2008) · Hormone Research in Paediatrics · doi:10.1159/000113020 · Cited by 35 · see citing works
Improda, N., Barbieri, F., Ciccarelli, G. P., Capalbo, D., & Salerno, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00212 · Cited by 34 · see citing works
Aloi, M., Tromba, L., Rizzo, V., D’Arcangelo, G., Dilillo, A., Blasi, S., Civitelli, F. S., Kiltzanidi, D., Redler, A., & Viola, F. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000771 · Cited by 34 · see citing works
Cardio-metabolic risk factors in youth with classical 21-hydroxylase deficiency
Ariyawatkul, K., Tepmongkol, S., Aroonparkmongkol, S., & Sahakitrungruang, T. (2017) · European Journal of Pediatrics · doi:10.1007/s00431-017-2875-2 · Cited by 34 · see citing works
Mooij, C. F., van Herwaarden, A. E., Sweep, F. C. G. J., Roeleveld, N., de Korte, C. L., Kapusta, L., & der Grinten, H. L. C. (2017) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2017-0068 · Cited by 32 · see citing works
Mooij, C. F., Webb, E. A., der Grinten, H. L. C., & Krone, N. P. (2016) · Archives of Disease in Childhood · doi:10.1136/archdischild-2016-311910 · Cited by 31 · see citing works
Sarafoglou, K., Merke, D. P., Reisch, N., der Grinten, H. L. C., Falhammar, H., & Auchus, R. J. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad134 · Cited by 31 · see citing works
Kim, M. S., Dao-Tran, A., Davidowitz, E., Tseng, T., Gilsanz, V., Ryabets‐Lienhard, A., Nguyen, E., & Geffner, M. E. (2016) · Hormone Research in Paediatrics · doi:10.1159/000444169 · Cited by 28 · see citing works
Moreira, R. P. P., Villares, S. M., Madureira, G., Mendonca, B. B., & Bachega, T. A. S. S. (2013) · Hormone Research in Paediatrics · doi:10.1159/000353762 · Cited by 27 · see citing works
Gomes, L. G., Mendonca, B. B., & Bachega, T. A. S. S. (2020) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000545 · Cited by 27 · see citing works
Glucocorticoids are active players and therapeutic targets in atherosclerotic cardiovascular disease
van der Sluis, R. J., & Hoekstra, M. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110728 · Cited by 27 · see citing works
Akyürek, N., Atabek, M. E., Eklioğlu, B. S., & Alp, H. (2015) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.1658 · Cited by 26 · see citing works
Rodrigues, T. M. B., Barra, C. B., Santos, J. L. S., Goulart, E. M. A., Ferreira, A. V. M., & Silva, I. N. (2015) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000119 · Cited by 26 · see citing works
Nengom, J. T., Sap, S. N. U., Chelo, D., Betoko, R. M., Boombhi, J., Tambo, F. M., Chiabi, A., Kingué, S., & Ndombo, P. K. (2017) · BMC Pediatrics · doi:10.1186/s12887-017-0862-4 · Cited by 26 · see citing works
Delai, A., Gomes, P. M., Foss‐Freitas, M. C., Elías, J., Antonini, S. R. R., de Castro, M., Moreira, A. C., & Mermejo, L. M. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab767 · Cited by 25 · see citing works
Kocova, M., Anastasovska, V., & Falhammar, H. (2020) · Endocrine · doi:10.1007/s12020-020-02323-3 · Cited by 24 · see citing works
Cardiometabolic Aspects of Congenital Adrenal Hyperplasia
Krysiak, R. G., der Grinten, H. L. C., Reisch, N., Touraine, P. A., & Falhammar, H. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae026 · Cited by 24 · see citing works
Metabolic syndrome and cardiovascular morbidity in patients with congenital adrenal hyperplasia
Barbot, M., Mazzeo, P., Lazzara, M., Ceccato, F., & Scaroni, C. M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.934675 · Cited by 23 · see citing works
Self-citationSubstitution therapy in adult patients with congenital adrenal hyperplasia
Reisch, N. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.11.002 · Cited by 23 · see citing works
Koç, A. S., & Sümbül, H. E. (2018) · Cardiovascular Ultrasound · doi:10.1186/s12947-018-0127-x · Cited by 21 · see citing works
Özdemir, R., Korkmaz, H. A., Küçük, M., Karadeniz, C., Meşe, T., & Özkan, B. (2016) · Clinical Endocrinology · doi:10.1111/cen.13275 · Cited by 21 · see citing works
Stewart, P. M., & Newell-Price, J. D. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00015-0 · Cited by 21 · see citing works
Kroese, J. M., Mooij, C. F., van der Graaf, M., Hermus, A. R., & Tack, C. J. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0523 · Cited by 21 · see citing works
Sarafoglou, K., Gonzalez‐Bolanos, M. T., Zimmerman, C. L., Boonstra, T., Yaw Addo, O., & Brundage, R. (2015) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.424 · Cited by 20 · see citing works
Arterial Stiffness in Transgender Men Receiving Long-term Testosterone Therapy
Cunha, F. S., Bachega, T. A. S. S., Costa, E. M. F., Brito, V. N., Alvares, L. A. M., Costa‐Hong, V., Verardino, R. G. S., Sircili, M. H. P., Mendonca, B. B., Bortolotto, L. A., et al. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad040 · Cited by 20 · see citing works
Components of Metabolic Syndrome in Youth With Classical Congenital Adrenal Hyperplasia
Kim, M. S., Fraga, N. R., Minaeian, N., & Geffner, M. E. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.848274 · Cited by 18 · see citing works
Congenital Adrenal Hyperplasia
Vos, A. A., & Bruinse, H. W. (2010) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e3181d61046 · Cited by 18 · see citing works
Hormonal treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Bachelot, A., Chakhtoura, Z., Rouxel, A., Dulon, J., & Touraine, P. A. (2007) · Annales d Endocrinologie · doi:10.1016/j.ando.2007.06.019 · Cited by 18 · see citing works
Adrenogenitales Syndrom und Wachstumshormonmangel
Dörr, H. G., & Schöfl, C. (2009) · Der Internist · doi:10.1007/s00108-009-2401-3 · Cited by 17 · see citing works
Mnif, M. F., Kamoun, M., Mnif, F., Charfi, N., Naceur, B. B., Kallel, N., Rekik, N. M., Mnif, Z., Sfar, M. H., Sfar, M., et al. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.102995 · Cited by 17 · see citing works
Early central blood pressure elevation in adult patients with 21-hydroxylase deficiency
Rosenbaum, D., Gallo, A., Lethielleux, G., Bruckert, E., Levy, B. I., Tanguy, M. L., Dulon, J., Dahmoune, N., Salem, J. E., Bittar, R., et al. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000001850 · Cited by 15 · see citing works
Grunt, S., Steinlin, M., Weisstanner, C., Schöning, M., Mullis, P. E., & Flück, C. E. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348515 · Cited by 13 · see citing works
Righi, B., Ali, S., Bryce, J., Tomlinson, J., Bonfig, W., Baronio, F., Costa, E. C., Guaragna‐Filho, G., T'Sjoen, G. G., Cools, M., et al. (2023) · Endocrine · doi:10.1007/s12020-023-03330-w · Cited by 13 · see citing works
Moreira, R. P. P., Gomes, L. G., Madureira, G., Mendonca, B. B., & Bachega, T. A. S. S. (2014) · International Journal of Endocrinology · doi:10.1155/2014/594710 · Cited by 13 · see citing works
Blood Pressure in Children with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Balagamage, C., Lawrence, N., Krone, R. E., Bacila, I. A., & Krone, N. P. (2023) · Hormone Research in Paediatrics · doi:10.1159/000533465 · Cited by 11 · see citing works
Charoensri, S., & Auchus, R. J. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad628 · Cited by 11 · see citing works
Cardiometabolic Health in Adolescents and Young Adults with Congenital Adrenal Hyperplasia
Navardauskaitė, R., Semeniene, K., Šukys, M., Pridotkaite, A., Vanckavičienė, A., Žilaitienė, B., & Verkauskienė, R. (2022) · Medicina · doi:10.3390/medicina58040500 · Cited by 9 · see citing works
Koç, A. S., Görgülü, F. F., Dönmez, Y., & İçen, Y. K. (2018) · Journal of Medical Ultrasonics · doi:10.1007/s10396-018-0877-y · Cited by 9 · see citing works
Borges, J. H., Santoro, R. I., de Oliveira, D. M., de Lemos‐Marini, S. H. V., Geloneze, B., Guerra‐Júnior, G., & Gonçalves, E. M. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14233 · Cited by 8 · see citing works
Hamada, S., Chin, K., Hitomi, T., Oga, T., Handa, T., Tuboi, T., Niimi, A., & Mishima, M. (2011) · Sleep And Breathing · doi:10.1007/s11325-011-0494-0 · Cited by 8 · see citing works
Amr, N. H., Mahmoud, R. A. A., Youssef, O., Toaima, N. N., & Elsedfy, H. H. (2020) · Clinical Endocrinology · doi:10.1111/cen.14333 · Cited by 8 · see citing works
Ocena funkcji serca oraz naczyń u pacjentów z klasyczną postacią wrodzonego przerostu nadnerczy
Wierzbicka-Chmiel, J., Chmiel, A., Rychlik, S., Ogrodowczyk-Bobik, M., Marek, B., & Kajdaniuk, D. (2015) · Endokrynologia Polska · doi:10.5603/ep.a2017.0046 · Cited by 8 · see citing works
Ho, H.-C., Chen, M.-F., Hwang, J., Lee, Y., & Su, T. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.836 · Cited by 8 · see citing works
Health problems of adolescent and adult patients with 21-hydroxylase deficiency
Tajima, T. (2018) · Clinical Pediatric Endocrinology · doi:10.1297/cpe.27.203 · Cited by 7 · see citing works
Metabolic evaluation of young women with congenital adrenal hyperplasia
Schnaider, G. S., de Lemos‐Marini, S. H. V., Baptista, M. T. M., Guerra‐Júnior, G., Morcillo, A. M., de Mello, M. P., de Oliveira, L. C., & D’Souza-Li, L. F. R. (2011) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302011000800021 · Cited by 7 · see citing works
Vascular and cardiac function in young adults with classical congenital adrenal hyperplasia
Wierzbicka-Chmiel, J., Chmiel, A., Kajdaniuk, D., & Marek, B. (2015) · Endocrine Abstracts · doi:10.1530/endoabs.37.gp.16.08 · Cited by 6 · see citing works
Apsan, J., Lekarev, O., Thomas, C., Zhu, Y., Cohan, K., & Lin‐Su, K. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1433378 · Cited by 5 · see citing works
Bachelot, A., & Touraine, P. A. (2014) · La Presse Médicale · doi:10.1016/j.lpm.2013.10.006 · Cited by 5 · see citing works
Zarić, S. P., Milenković, T., Todorovic, S., Mitrović, K., Cvetković, D., Cehic, M., Vekić, J., Dumic, K. K., & Vuković, R. (2025) · Metabolites · doi:10.3390/metabo15020089 · Cited by 4 · see citing works
Metabolic disorders in the adult patients presenting with congenital adrenal hyperpl
Игоревна, С. А., Troshina, E. A., & Молашенко, Н. В. (2012) · Problems of Endocrinology · doi:10.14341/probl20125853-9 · Cited by 4 · see citing works
Al-Rayess, H., Addo, O. Y., Palzer, E. F., Jaber, M. M., Fleissner, K., Hodges, J. S., Brundage, R. C., Miller, B. S., & Sarafoglou, K. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab193 · Cited by 4 · see citing works
Genome-wide investigation of DNA methylation in congenital adrenal hyperplasia
Karlsson, L., Barbaro, M., Ewing, E., Gómez-Cabrero, D., & Lajić, S. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105699 · Cited by 4 · see citing works
Hubska, J., Roszkowska, Z., Bobrowicz, M., Iwaniuk, S., Rak, B., & Ambroziak, U. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1581681 · Cited by 3 · see citing works
TUHAN, H., Öztürk, T., Çatlı, G., Acar, S., Abacı, A., Egeli, T. Ü., Demir, K., Can, Ş., Güleryüz, H., Dündar, B. N., et al. (2021) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-2001-57 · Cited by 3 · see citing works
Ağırbaşlı, M. A., Baykan, O. A., Tekin, A., Şengör, F., Cincin, A. A., Demir, M., & Vaughan, D. E. (2008) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-007-0188-4 · Cited by 3 · see citing works
Suceava, I., Lighezan, D., Serban, C., Lighezan, R., Gurban, C., & Dragan, S. R. (2013) · Europe PMC (PubMed Central) · Cited by 3 · see citing works
Congenital adrenal hyperplasia
Krone, N. P. (2011) · doi:10.1093/med/9780199235292.003.0616 · Cited by 3 · see citing works
Widodo, A. D., Batubara, J. R. L., Ifran, E. K. B., Akib, A. A., Pardede, S. O., & Setyanto, D. B. (2016) · Sari Pediatri · doi:10.14238/sp12.5.2011.307-14 · Cited by 2 · see citing works
- Authors
- Sartorato, P., Zulian, E., Benedini, S., Mariniello, B., Schiavi, F., Bilora, F., Pozzan, G., Greggio, N., Pagnan, A., Mantero, F., & Scaroni, C.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Scaroni, C.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2007-03-01
- Volume
- 92
- Issue
- 3
- Pages
- 1015-1018
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2030280115
- Cited by
- 132
- References
- 22
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 9 · 2013: 9 · 2012: 6
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (other-oa)
- Funders
- Università degli Studi di Padova
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- congenital adrenal hyperplasia, 21-hydroxylase deficiency, intima-media thickness, subclinical atherosclerosis, cardiovascular risk factors, insulin resistance, insulin, carotid artery, femoral artery, abdominal aorta, carotid bulb, glucose metabolism, lipid profile, glucocorticoid dose, androgens, salt wasting, adults
- MeSH terms
- Adrenal Hyperplasia, Congenital, Adult, Aorta, Abdominal, Blood Glucose, Cardiovascular Diseases, Female, Femoral Artery, Glucose Tolerance Test, Hormones, Humans, Insulin, Insulin Resistance, Male, Risk Factors, Ultrasonography, Case-Control Studies, Carotid Artery, Common, Tunica Intima
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
