SOX Genes: Architects of Development
Open accessAbstract
Development in higher organisms involves complex genetic regulation at the molecular level. The emerging picture of development control includes several families of master regulatory genes which can affect the expression of down-stream target genes in developmental cascade pathways. One new family of such development regulators is the SOX gene family. The SOX genes are named for a shared motif called the SRY box a region homologous to the DNA-binding domain of SRY, the mammalian sex determining gene. Like SRY, SOX genes play important roles in chordate development. At least a dozen human SOX genes have been identified and partially characterized (Tables 1 and 2). Mutations in SOX9 have recently been linked to campomelic dysplasia and autosomal sex reversal, and other SOX genes may also be associated with human disease.
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The study examined expression patterns of several transcription factor families (Fox, Klf, Lhx, Nkx, Nr, Pax, Pou, Prdm, Sox, Tbx), all of which have been shown to have important roles in spatial patterning, cell-type specification and differentiation during development.
“We examined the expression patterns of several transcription factor families (Extended Data Fig. 13), including forkhead box (Fox), Krüppel-like factor (Klf), LIM homeobox (Lhx), NKX-homeodomain (Nkx), nuclear receptor (Nr), Paired box (Pax), POU domain (Pou), positive regulatory domain (Prdm), SRY-related HMG-box (Sox), and T-box (Tbx), all of which have been shown to have important roles in”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [104]
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Cites
Sinclair, A. H., Berta, P., Palmer, M. S., Hawkins, J. R., Griffiths, B. L., Smith, M. J., Foster, J. W., Frischauf, A., Lovell-Badge, R. H., & Goodfellow, P. N. (1990) · Nature · doi:10.1038/346240a0 · Cited by 3,234 · see citing works
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
Mitchell, P. J., & Tjian, R. (1989) · Science · doi:10.1126/science.2667136 · Cited by 3,046 · see citing works
MERRITT, A. D. (2011) · Springer eBooks · doi:10.1007/springerreference_33432 · Cited by 2,522 · see citing works
Male development of chromosomally female mice transgenic for Sry
Koopman, P. A., Gubbay, J., Vivian, N., Goodfellow, P. N., & Lovell-Badge, R. H. (1991) · Nature · doi:10.1038/351117a0 · Cited by 2,193 · see citing works
Hox genes in vertebrate development
Krumlauf, R. K. (1994) · Cell · doi:10.1016/0092-8674(94)90290-9 · Cited by 2,048 · see citing works
Gubbay, J., Collignon, J., Koopman, P. A., Capel, B., Economou, A., Münsterberg, A., Vivian, N., Goodfellow, P. N., & Lovell-Badge, R. H. (1990) · Nature · doi:10.1038/346245a0 · Cited by 1,675 · see citing works
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene
Foster, J. W., Dominguez-Steglich, M., Guioli, S., Kwok, C., Weller, P., Stevanović, M., Weissenbach, J., Mansour, S., Young, I., Goodfellow, P., et al. (1994) · Nature · doi:10.1038/372525a0 · Cited by 1,602 · see citing works
Wagner, T., Wirth, J., Meyer, J., Zabel, B., Held, M., Zimmer, J., Pasantes, J., Bricarelli, F. D., Keutel, J., Hustert, E., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90041-8 · Cited by 1,592 · see citing works
Sex Chromosomes and Sex-Linked Genes
Ohno, S. (1967) · Monographs on endocrinology · doi:10.1007/978-3-642-88178-7 · Cited by 1,497 · see citing works
Sex Chromosomes and Sex-linked Genes.
(1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-68-6-1375_2 · Cited by 1,324 · see citing works
Transcriptional activation: A complex puzzle with few easy pieces
Tjian, R., & Maniatis, T. (1994) · Cell · doi:10.1016/0092-8674(94)90227-5 · Cited by 1,108 · see citing works
Circular transcripts of the testis-determining gene Sry in adult mouse testis
Capel, B., Swain, A., Nicolis, S. K., Hacker, A., Walter, M. A., Koopman, P. A., Goodfellow, P. N., & Lovell-Badge, R. H. (1993) · Cell · doi:10.1016/0092-8674(93)90279-y · Cited by 1,100 · see citing works
Self-citationGenetic evidence equating SRY and the testis-determining factor
Berta, P., Hawkins, J. B., Sinclair, A. H., Taylor, A., Griffiths, B. L., Goodfellow, P. N., & Fellous, M. (1990) · Nature · doi:10.1038/348448a0 · Cited by 980 · see citing works
HMG domain proteins: architectural elements in the assembly of nucleoprotein structures
Grosschedl, R., Giese, K., & Pagel, J. M. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90232-1 · Cited by 817 · see citing works
Yuan, H., Corbi, N., Basilico, C., & Dailey, L. (1995) · Genes & Development · doi:10.1101/gad.9.21.2635 · Cited by 811 · see citing works
Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene
Tassabehji, M., Read, A., Newton, V., et al. (1992) · Nature · doi:10.1038/355635a0 · Cited by 699 · see citing works
Giese, K., Cox, J. S., & Grosschedl, R. (1992) · Cell · doi:10.1016/0092-8674(92)90129-z · Cited by 685 · see citing works
Sanyanusin, P., Schimmenti, L. A., McNoe, L. A., Ward, T. A., Pierpont, M. E., Sullivan, M. J., Dobyns, W. B., & Eccles, M. R. (1995) · Nature Genetics · doi:10.1038/ng0495-358 · Cited by 662 · see citing works
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
Wright, E. M., Hargrave, M. R., Christiansen, J. H., Cooper, L. T., Kun, J., Evans, T. M., Gangadharan, U., Greenfield, A., & Koopman, P. A. (1995) · Nature Genetics · doi:10.1038/ng0195-15 · Cited by 661 · see citing works
Travis, A., Amsterdam, A., Bélanger, C., & Grosschedl, R. (1991) · Genes & Development · doi:10.1101/gad.5.5.880 · Cited by 614 · see citing works
The human PAX6 gene is mutated in two patients with aniridia
Jordan, T., Hanson, I. M., Zaletaev, D. V., Hodgson, S. V., Prosser, J., Seawright, A., Hastie, N. D., & van Heyningen, V. (1992) · Nature Genetics · doi:10.1038/ng0892-328 · Cited by 572 · see citing works
Expression of Sry , the mouse sex determining gene
Hacker, A., Capel, B., Goodfellow, P. N., & Lovell-Badge, R. H. (1995) · Development · doi:10.1242/dev.121.6.1603 · Cited by 571 · see citing works
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
Collignon, J., Sockanathan, S., Hacker, A., Cohen‐Tannoudji, M., Norris, D. P., Rastan, S., Stevanović, M. J., Goodfellow, P. N., & Lovell-Badge, R. H. (1996) · Development · doi:10.1242/dev.122.2.509 · Cited by 496 · see citing works
Blancato, J. K. (1993) · Reproductive Toxicology · doi:10.1016/0890-6238(93)90275-c · Cited by 455 · see citing works
SRY, like HMG1, recognizes sharp angles in DNA.
Ferrari, S., Harley, V. R., Pontiggia, A., Goodfellow, P. N., Lovell-Badge, R. H., & Bianchi, M. E. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05551.x · Cited by 440 · see citing works
Cellular peptide composition governed by major histocompatibility complex class I molecules
Falk, K., Rötzschke, O., & Rammensee, H. (1990) · Nature · doi:10.1038/348248a0 · Cited by 436 · see citing works
Uwanogho, D., Rex, M., Cartwright, E. J., Pearl, G., Healy, C., Scotting, P. J., & Sharpe, P. T. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(94)00299-3 · Cited by 391 · see citing works
Definition of a consensus DNA binding site for SRY
Harley, V. R., Lovell-Badge, R. H., & Goodfellow, P. N. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.8.1500 · Cited by 386 · see citing works
Dimers, leucine zippers and DNA-binding domains
Busch, S. J., & Sassone‐Corsi, P. (1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90071-d · Cited by 378 · see citing works
Sox‐4, an Sry‐like HMG box protein, is a transcriptional activator in lymphocytes.
van de Wetering, M., Oosterwegel, M. A., van Norren, K., & Clevers, H. C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06063.x · Cited by 348 · see citing works
Ancestry and diversity of the HMG box superfamily
Laudet, V., Stéhelin, D., & Clevers, H. C. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.10.2493 · Cited by 334 · see citing works
Struhl, K. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90145-x · Cited by 306 · see citing works
Foster, J. W., & Graves, J. A. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1927 · Cited by 283 · see citing works
Houston, C., Opitz, J. M., Spranger, J., Macpherson, R. I., Reed, M. H., Gilbert, E. F., Herrmann, J., & Schinzel, A. (1983) · American journal of medical genetics · doi:10.1002/ajmg.1320150103 · Cited by 282 · see citing works
SOX3 is an X-linked gene related to SRY
Stevanović, M. J., Lovell-Badge, R. H., Collignon, J., & Goodfellow, P. N. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.12.2013 · Cited by 259 · see citing works
Denny, P., Swift, S., Connor, F., & Ashworth, A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05455.x · Cited by 256 · see citing works
Haqq, C., King, C., Ukiyama, E., Falsafi, S., Haqq, T. N., Donahoe, P. K., & Weiss, M. A. (1994) · Science · doi:10.1126/science.7985018 · Cited by 256 · see citing works
New perspectives on eye evolution
Halder, G. A., Callaerts, P., & Gehring, W. J. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80029-8 · Cited by 248 · see citing works
Involvement of SOX proteins in lens‐specific activation of crystallin genes.
Kamachi, Y., Sockanathan, S., Liu, Q., et al. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07357.x · Cited by 237 · see citing works
van de Wetering, M., & Clevers, H. C. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05374.x · Cited by 221 · see citing works
Seven new members of theSoxgene family expressed during mouse development
Wright, E. M., Snopek, B., & Koopman, P. A. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.3.744 · Cited by 216 · see citing works
Tommerup, N., Schempp, W., Meinecke, P., Pedersen, S., Bolund, L., Brandt, C., Goodpasture, C., Guldberg, P., Held, K. R., Reinwein, H., et al. (1993) · Nature Genetics · doi:10.1038/ng0693-170 · Cited by 195 · see citing works
Clépet, C., Schater, A. J., Sinclair, A. H., Palmer, M. S., Lovell-Badge, R. H., & Goodfellow, P. N. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.12.2007 · Cited by 176 · see citing works
Myoblast diversity in skeletal myogenesis: How much and to what end?
Miller, J. B. (1992) · Cell · doi:10.1016/0092-8674(92)90111-o · Cited by 162 · see citing works
A conserved family of genes related to the testis determining gene,SRY
DENNY, P. C., Swift, S., Brand, N. J., et al. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.11.2887 · Cited by 150 · see citing works
Mutation of the PAX6 gene in patients with autosomal dominant keratitis.
Mirzayans, F., Pearce, W. G., MacDonald, I. M., et al. (1995) · PubMed · Cited by 147 · see citing works
Connor, F., Wright, E. M., Denny, P., Koopman, P. A., & Ashworth, A. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.17.3365 · Cited by 145 · see citing works
DNA binding and bending properties of the postmeiotically expressed Sry-related protein Sox-5
Connor, F., Cary, P. D., Read, C. M., Preston, N. S., Driscoll, P. C., Denny, P., Crane‐Robinson, C., & Ashworth, A. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.16.3339 · Cited by 145 · see citing works
The cDNA sequence and chromosomal location of the human SOX2 gene
Stevanović, M. J., Zuffardi, O., Collignon, J., et al. (1994) · Mammalian Genome · doi:10.1007/bf00411460 · Cited by 103 · see citing works
Waterman, M. L., & Jones, K. A. (1990) · PubMed · Cited by 95 · see citing works
Griffiths, R. (1991) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1991.0060 · Cited by 77 · see citing works
Evidence That the SRY Protein Is Encoded by a Single Exon on the Human Y Chromosome
Behlke, M. A., Bogan, J. S., Beer‐Romero, P., et al. (1993) · Genomics · doi:10.1006/geno.1993.1395 · Cited by 69 · see citing works
Coriat, A., Müller, U., Harry, J. L., et al. (1993) · Genome Research · doi:10.1101/gr.2.3.218 · Cited by 65 · see citing works
Characterization and mapping of the human SOX4 gene
Farr, C. J., Easty, D. J., Ragoussis, J., et al. (1993) · Mammalian Genome · doi:10.1007/bf00361388 · Cited by 59 · see citing works
Sequence and expression of Sox-18 encoding a new HMG-box transcription factor
Dunn, T. L., Mynett‐Johnson, L., Wright, E. M., et al. (1995) · Gene · doi:10.1016/0378-1119(95)00280-j · Cited by 55 · see citing works
Vriz, S., & Lovell-Badge, R. H. (1995) · Gene · doi:10.1016/0378-1119(94)00815-a · Cited by 44 · see citing works
Molecular genetics of the Pax gene family
Hill, R. E., & Hanson, I. M. (1992) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(92)90126-w · Cited by 39 · see citing works
SOX20, a new member of the SOX gene family, is located on chromosome 17p13
Meyer, J., Wirth, J., Held, M., et al. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134200 · Cited by 24 · see citing works
The murine Sox-4 protein is encoded on a single exon
Schiham, M. W., van Eijk, M., van de Wetering, M., et al. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.8.2009 · Cited by 19 · see citing works
Pw Sox-1: the first member of the Sox gene family in Urodeles
Chardard, D., Chesnel, A., Gozé, C., et al. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.15.3576 · Cited by 16 · see citing works
Partial cloning of SOX-11 and SOX-12, two new human SOX genes
Gozé, C., Poulat, F., & Berta, P. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.12.2943 · Cited by 15 · see citing works
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A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,194 · see citing works
- Authors
- Prior, H. M., & Walter, M. A.
- Affiliations
- University of Alberta (CA)
- ORCID
- Walter, Michael A.
- Venue
- Molecular Medicine
- Published
- 1996-07
- Volume
- 2
- Issue
- 4
- Pages
- 405-412
- ISSN
- 1076-1551 (ISSN-L)
- 1528-3658
- PMC
- PMC2230175
- OpenAlex
- W1858567034
- Cited by
- 103
- References
- 61
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Sox genes, developmental gene regulation, SRY, SOX9, campomelic dysplasia, chordate development, DNA-binding domain
- MeSH terms
- Amino Acid Sequence, Animals, Chromosome Mapping, DNA-Binding Proteins, Gene Expression Regulation, Genes, Homeobox, High Mobility Group Proteins, Humans, Molecular Sequence Data, Nuclear Proteins, Sex Determination Analysis, Transcription Factors, Sex-Determining Region Y Protein, SOXB1 Transcription Factors, SOXC Transcription Factors, SOXD Transcription Factors
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