Ratio of neutrophil to lymphocyte counts — rapid and simple parameter of systemic inflammation and stress in critically ill
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ICRs indicate the balance between innate and adaptive immune responses and are an excellent indicator of inflammation and stress together.
“Zahorec et al. concluded that ICRs “indicate the balance between innate and adaptive immune responses and are an excellent indicator of inflammation and stress together” [26].”
From Immune Cell Ratios Are Higher in Bipolar Affective than Unipolar Depressive Disorder and Modulated by Mood Episode: A Retrospective, Cross-Sectional Study (2023) · cites this paper as [26]
ICRs have been repeatedly proposed as solid prognostic markers for various additional conditions including low-grade inflammation, rheumatic diseases, sepsis, myocarditis, thrombosis, ischemic and cardiovascular events, autoimmune and systemic diseases, cancer incidence, progression, response and outcome, COVID-19 severity and prognosis, critical illness, and overall mortality.
“Since then, IRCs have been repeatedly proposed as solid prognostic markers for various additional conditions including low-grade inflammation, rheumatic diseases, sepsis, myocarditis, thrombosis, ischemic and cardiovascular events, autoimmune and systemic diseases, cancer incidence, progression, response and outcome, COVID-19 severity and prognosis, critical illness, and overall mortality [26,27,2”
From Immune Cell Ratios Are Higher in Bipolar Affective than Unipolar Depressive Disorder and Modulated by Mood Episode: A Retrospective, Cross-Sectional Study (2023) · cites this paper as [26]
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“concluded that ICRs “indicate the balance between innate and adaptive immune responses and are an excellent indicator of inflammation and stress together” [26].”
Background
- Authors
- Zahorec, R.
- Venue
- Bratislava Medical Journal
- Published
- 2001-01
- Volume
- 102
- Issue
- 1
- Pages
- 5-14
- ISSN
- 0006-9248 (ISSN-L)
- 1336-0345
- OpenAlex
- W1430642159
- Cited by
- 1,601
- References
- 0
- Citations by year
- 2026: 29 · 2025: 110 · 2024: 133 · 2023: 139 · 2022: 131 · 2021: 186 · 2020: 184 · 2019: 115 · 2018: 109 · 2017: 102 · 2016: 82 · 2015: 66 · 2014: 53 · 2013: 60 · 2012: 30
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Bratislavské lekárske listy/Bratislava medical journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- neutrophil-to-lymphocyte ratio, systemic inflammation, surgical stress response, sepsis, septic shock, lymphopenia, neutrophilia, differential leukocyte count, colorectal surgery, critically ill patients, SOFA score, APACHE II score, prognostic factors, white blood cell count monitoring, immunosuppression
- MeSH terms
- Abdomen, Adult, Aged, Aged, 80 and over, Emergencies, Humans, Leukocyte Count, Middle Aged, Neutrophils, Prospective Studies, Stress, Physiological, Surgical Procedures, Operative, Critical Illness, Lymphocyte Count, Systemic Inflammatory Response Syndrome, APACHE
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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