The plasminogen activator system: biology and regulation

Protease nexin-1-urokinase complexes are internalized and degraded through a mechanism that requires both urokinase receptor and alpha 2-macroglobulin receptor.

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Stimulation of Tissue-Type Plasminogen Activator Synthesis by Retinoids in Cultured Human Endothelial Cells and Rat Tissues In Vivo

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Requirement of an Upstream AP-1 Motif for the Constitutive and Phorbol Ester-inducible Expression of the Urokinase-type Plasminogen Activator Receptor Gene

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Multiple Instability-Regulating Sites in the 3′ Untranslated Region of the Urokinase-Type Plasminogen Activator mRNA

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Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblasts.

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Characterization of human involucrin promoter distal regulatory region transcriptional activator elements–a role for Sp1 and AP1 binding sites

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AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm

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Signal transduction and the u-PA/u-PAR system

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Plasminogen activator inhibitor type 2 prevents programmed cell death of human macrophages infected with Mycobacterium avium, serovar 4

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Cytoskeleton Reorganization Induces the Urokinase-type Plasminogen Activator Gene via the Ras/Extracellular Signal-regulated Kinase (ERK) Signaling Pathway

Irigoyen, J. P., Besser, D., & Nagamine, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1904 · Cited by 75

Isolation and characterization of the rat plasminogen activator inhibitor-1 gene.

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Reversion of the invasive phenotype of transformed human fibroblasts by anti-messenger oligonucleotide inhibition of urokinase receptor gene expression.

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The Destabilizing Elements in the Coding Region of c- fos mRNA Are Recognized as RNA

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Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2

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Induction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-alpha.

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Posttranscriptional regulation of urokinase plasminogen activator receptor messenger RNA levels by leukocyte integrin engagement

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The structure of the TATA-less rat tissue-type plasminogen activator gene. Species-specific sequence divergences in the promoter predict differences in regulation of gene expression.

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The expression of an Ets1 transcription factor lacking its activation domain decreases uPA proteolytic activity and cell motility, and impairs normal tubulogenesis and cancerous scattering in mammary epithelial cells

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Transcription Factor Sp1 Is Important for Retinoic Acid-Induced Expression of the Tissue Plasminogen Activator Gene during F9 Teratocarcinoma Cell Differentiation

Darrow, A. L., Rickles, R. J., Pecorino, L. T., & Strickland, S. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.11.5883 · Cited by 61

Attachment of cultured human endothelial cells is promoted by specific association with S protein (vitronectin) as well as with the ternary S protein-thrombin-antithrombin III complex

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Protein synthesis inhibition stabilizes urokinase-type plasminogen activator mRNA. Studies in vivo and in cell-free decay reactions.

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Transcriptional and posttranscriptional activation of urokinase plasminogen activator gene expression in metastatic tumor cells.

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UV Irradiation Induces the Murine Urokinase-Type Plasminogen Activator Gene via the c-Jun N-Terminal Kinase Signaling Pathway: Requirement of an AP1 Enhancer Element

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Retinoic Acid Induction of Human Tissue-type Plasminogen Activator Gene Expression via a Direct Repeat Element (DR5) Located at −7 Kilobases

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Regulatory elements involved in constitutive and phorbol ester-inducible expression of the plasminogen activator inhibitor type 2 gene promoter

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Cytoskeletal reorganization and TPA differently modify AP-1 to induce the urokinase-type plasminogen activator gene in LLC-PK1cells

Lee, J. S., von der Ahe, D., Kiefer, B., & Nagamine, Y. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.15.3365 · Cited by 55

The murine urokinase-type plasminogen activator gene

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Role of protein kinase C and cyclic adenosine monophosphate in the regulation of tissue-type plasminogen activator, plasminogen activator inhibitor-1, and platelet-derived growth factor mRNA levels in human endothelial cells. Possible involvement of proto-oncogenes c-jun and c-fos.

Kooistra, T., Bosma, P. J., Toet, K. H., Cohen, L. H., Griffioen, M., van den Berg, E., le Clercq, L., & van Hinsbergh, V. W. M. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.4.1042 · Cited by 53

Phosphorylation of Human Pro-Urokinase on Ser138/303 Impairs Its Receptor-dependent Ability to Promote Myelomonocytic Adherence and Motility

Franco, P., Iaccarino, C., Chiaradonna, F., Brandazza, A., Iavarone, C., Mastronicola, M. R., Nolli, M. L., & Stoppelli, M. P. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.3.779 · Cited by 50

Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5′ non-coding sequences that are conserved between mouse and pig

Cassady, A. I., Stacey, K. J., Nimmo, K. A., Murphy, K. M., von der Ahe, D., Pearson, D., Botteri, F. M., Nagamine, Y., & Hume, D. A. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.24.6839 · Cited by 50

Characterization of a Helicase-Like Transcription Factor Involved in the Expression of the Human Plasminogen Activator Inhibitor-1 Gene

Ding, H., Descheemaeker, K. A., Marynen, P., Nelles, L., Carvalho, T., Carmo‐Fonseca, M., Collen, D., & Belayew, A. (1996) · DNA and Cell Biology · doi:10.1089/dna.1996.15.429 · Cited by 49

Stimulation of urokinase-type plasminogen activator receptor expression by PMA requires JNK1-dependent and -independent signaling modules

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Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins

Higazi, A. A., Upson, R. H., Cohen, R., Manuppello, J. R., Bognacki, J. J., Henkin, J., McCrae, K., Kounnas, M., Strickland, D., Preissner, K., et al. (1996) · Blood · doi:10.1182/blood.v88.2.542.bloodjournal882542 · Cited by 47

Complex regulation of plasminogen activator inhibitor type-1 (PAI-1) gene expression by serum and substrate adhesion

RYAN, M. P., Kutz, S. M., & Higgins, P. J. (1996) · Biochemical Journal · doi:10.1042/bj3141041 · Cited by 46

Cyclic Nucleotide Regulation of PAI-1 mRNA Stability

Tillmann-Bogush, M., Heaton, J. H., & GELEHRTER, T. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1172 · Cited by 45

Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro

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Transcriptional and posttranscriptional regulation of type 1 plasminogen activator inhibitor and tissue-type plasminogen activator gene expression in HTC rat hepatoma cells by glucocorticoids and cyclic nucleotides.

Heaton, J. H., Kathju, S., & GELEHRTER, T. D. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.1.1738371 · Cited by 42

Receptor-mediated endocytosis of urokinase-type plasminogen activator is regulated by cAMP-dependent protein kinase

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Transactivation of the Urokinase-type Plasminogen Activator Receptor Gene through a Novel Promoter Motif Bound with an Activator Protein-2α-related Factor

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Role of C‐Jun and Proximal Phorbol 12‐Myristate‐13‐Acetate‐(PMA)‐Responsive Elements in the Regulation of Basal and PMA‐Stimulated Plasminogen‐Activator Inhibitor‐1 Gene Expression in HepG2

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Enhanced Stability of Urokinase‐Type Plasminogen Activator mRNA in Metastatic Breast Cancer MDA‐MB‐231 Cells and LLC‐PK1 Cells Down‐Regulated for Protein Kinase C — Correlation with Cytoplasmic Heterogeneous Nuclear Ribonucleoprotein C

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A common response element mediates differential effects of phorbol esters and forskolin on type‐1 plasminogen activator inhibitor gene expression in human breast carcinoma cells

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Protein kinase C down-regulation enhances cAMP-mediated induction of urokinase-type plasminogen activator mRNA in LLC-PK1 cells.

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Cyclic Nucleotide Regulation of Type-1 Plasminogen Activator-Inhibitor mRNA Stability in Rat Hepatoma Cells

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Okadaic acid-dependent induction of the urokinase-type plasminogen activator gene associated with stabilization and autoregulation of c-Jun.

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The murine urokinase-type plasminogen activator receptor gene

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Regulatory sequences and protein-binding sites involved in the expression of the rat plasminogen activator inhibitor-1 gene.

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Transcriptional Regulation of the Rat Tissue type Plasminogen Activator Gene: Localization of DNA Elements and Nuclear Factors Mediating Constitutive and Cyclic AMP-Induced Expression

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Rapamycin Destabilizes Interleukin-3 mRNA in Autocrine Tumor Cells by a Mechanism Requiring an Intact 3′ Untranslated Region

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Regulation of the plasminogen activator inhibitor type-2 gene in monocytes: localization of an upstream transcriptional silencer

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Differential regulation of the plasminogen activator inhibitor-1 (PAI- 1) gene expression by growth factors and progesterone in human endometrial stromal cells

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Differential Binding of cAMP‐responsive‐element(CRE)‐binding Protein‐1 and Activating Transcription Factor‐2 to a CRE‐Like Element in the Human Tissue‐Type Plasminogen Activator (t‐PA) Gene Promoter Correlates with Opposite Regulation of t‐PA by Phorbol Ester in HT‐1080 and HeLa Cells

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Expression of c-ets-1 and uPA genes is associated with mammary epithelial cell tubulogenesis or neoplastic scattering

Delannoy-Courdent, A., Fauquette, W., Bourhis, X. L., Boilly, B., Vandenbunder, B., & Desbiens, X. (1996) · The International Journal of Developmental Biology · doi:10.1387/ijdb.9032015 · Cited by 33

Ca2+ potentiates cAMP-dependent expression of urokinase-type plasminogen activator gene through a calmodulin- and protein kinase C-independent mechanism.

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The Species-Specific Differences in the cAMP Regulation of the Tissue-Type Plasminogen Activator Gene between Rat, Mouse and Human is Caused by a One-Nucleotide Substitution in the cAMP-Responsive Element of the Promoters

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Heparin‐binding Epidermal Growth Factor‐like Growth Factor: p91 Activation, Induction of Plasminogen Activator/Plasminogen Activator Inhibitor, and Tubular Morphogenesis in Human Microvascular Endothelial Cells

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A novel protein interacts with the major transforming growth factor-beta responsive element in the plasminogen activator inhibitor type-1 gene.

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Regulation of type I plasminogen activator inhibitor synthesis by protein kinase C and cAMP in bovine aortic endothelial cells

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In Vitro Analysis of the Tissue Plasminogen Activator Promoter Reveals a GC Box-Binding Activity Present in Murine Brain but Undetectable in Kidney and Liver

Pecorino, L. T., Darrow, A. L., & Strickland, S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.6.3139-3147.1991 · Cited by 31

Interleukin-1 induction of type-1 plasminogen activator inhibitor (PAI-1) gene expression in the mouse hepatocyte line, AML 12

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Molecular Mechanisms Governing Tumor‐Necrosis‐Factor‐Mediated Regulation of Plasminogen‐Activator Inhibitor Type‐2 Gene Expression

Dear, A. E., Shen, Y., Rüegg, M., & Medcalf, R. L. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0093t.x · Cited by 26

Stimulation of urokinase expression by TNF-α requires the activation of binding sites for the AP-1 and PEA3 transcription factors

Lengyel, E. R., Klostergaard, J., & Boyd, D. D. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(95)00050-3 · Cited by 25

Glucocorticoids Stimulate Plasminogen Activator Production by Rat Granulosa Cells*

Wang, C., & LEUNG, A. (1989) · Endocrinology · doi:10.1210/endo-124-4-1595 · Cited by 24

Fibrinogen and fibrin in the arterial wall

Bini, A., & Kudryk, B. J. (1994) · Thrombosis Research · doi:10.1016/0049-3848(94)90247-x · Cited by 24

Multiple nuclear factors interact with promoter sequences of the urokinase-type plasminogen activator gene

von der Ahe, D., Pearson, D., Nakagawa, J., Rajput, B., & Nagamine, Y. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.15.7527 · Cited by 20

Dexamethasone decreases urokinase plasminogen activator mRNA stability in MAT 13762 rat mammary carcinoma cells

Henderson, B., & Kefford, R. F. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.16 · Cited by 19

Synergistic induction of tissue-type plasminogen activator gene expression by glucocorticoids and cyclic nucleotides in rat HTC hepatoma cells

Kathju, S., Heaton, J. H., Bruzdzinski, C. J., & GELEHRTER, T. D. (1994) · Endocrinology · doi:10.1210/en.135.3.1195 · Cited by 19

In Vivo Antisense Oligodeoxynucleotide Mapping Reveals Masked Regulatory Elements in an mRNA Dormant in Mouse Oocytes

Stutz, A., Huarte, J., Gubler, P., Conne, B., Belin, D., & Vassalli, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.1759 · Cited by 18

Diminished Fibrinolysis in Diabetes Mellitus and its Implication for Diabetic Vascular Disease

Panahloo, A., & Yudkin, J. S. (1997) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182679700400205 · Cited by 16

Characterization of UEF-4, a DNA-binding Protein Required for Transcriptional Synergism between Two AP-1 Sites in the Human Urokinase Enhancer

Cesare, D. D., Palazzolo, M., Berthelsen, J., & Blasi, F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23921 · Cited by 15

Cloning of the mink plasminogen activator inhibitor type-1 messenger RNA: An mRNA with a short half life

Chuang, T., Hamilton, R. T., & Nilsen‐Hamilton, M. (1995) · Gene · doi:10.1016/0378-1119(95)00261-4 · Cited by 7

Purification and Characterization of a 5′ to 3′ Exoribonuclease from Rabbit Reticulocytes that Degrades Capped and Uncapped RNAs

Somoskeöy, S., Rao, M. N., & Slobin, L. I. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0171n.x · Cited by 6

The extracellular matrix in breast cancer

Insua-Rodríguez, J., & Oskarsson, T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.017 · Cited by 470

Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications

Mahmood, N., Mihalcioiu, C., & Rabbani, S. A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00024 · Cited by 478

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes

Fata, J. E., Werb, Z., & Bissell, M. J. (2003) · Breast Cancer Research · doi:10.1186/bcr634 · Cited by 383

MATHEMATICAL MODELLING OF CANCER CELL INVASION OF TISSUE: THE ROLE OF THE UROKINASE PLASMINOGEN ACTIVATION SYSTEM

CHAPLAIN, M. A. J., & LOLAS, G. (2005) · Mathematical Models and Methods in Applied Sciences · doi:10.1142/s0218202505000947 · Cited by 323

The urokinase plasminogen activator system: a target for anti-cancer therapy

Ulisse, S., Baldini, E., Sorrenti, S., & D'Armiento, M. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909787314002 · Cited by 312