The extracellular matrix in breast cancer

Global cancer statistics

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Global cancer statistics, 2012

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Remodelling the extracellular matrix in development and disease

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Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

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Tensional homeostasis and the malignant phenotype

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Integrins in cancer: biological implications and therapeutic opportunities

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

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Genes that mediate breast cancer metastasis to lung

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Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

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Collective cell migration in morphogenesis, regeneration and cancer

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A multigenic program mediating breast cancer metastasis to bone

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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

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A molecular signature of metastasis in primary solid tumors

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Extracellular Matrix Degradation and Remodeling in Development and Disease

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Hyaluronan: from extracellular glue to pericellular cue

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Endogenous human microRNAs that suppress breast cancer metastasis

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Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

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Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

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The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

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Collagen density promotes mammary tumor initiation and progression

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Interactions between cancer stem cells and their niche govern metastatic colonization

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multifunctional enzymes in cancer

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Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages

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Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor

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The perivascular niche regulates breast tumour dormancy

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Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

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Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

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The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

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Dynamic interplay between the collagen scaffold and tumor evolution

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Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

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Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis

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Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

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Metastatic Stem Cells: Sources, Niches, and Vital Pathways

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Heparan sulphate proteoglycans: the sweet side of development

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Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

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Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

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Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

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Fibronectin Polymerization Regulates the Composition and Stability of Extracellular Matrix Fibrils and Cell-Matrix Adhesions

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Mechanical compression drives cancer cells toward invasive phenotype

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Metalloproteinases: role in breast carcinogenesis, invasion and metastasis

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Mammographic density and breast cancer risk: current understanding and future prospects

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Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients

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Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511

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ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix

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Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

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The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state?

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The ThrombospondinsPreprint

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Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin

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Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

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Metastatic Growth from Dormant Cells Induced by a Col-I–Enriched Fibrotic Environment

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Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2

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Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

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VEGF-A and Tenascin-C produced by S100A4 ⁺ stromal cells are important for metastatic colonization

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Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

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β1 Integrin Inhibitory Antibody Induces Apoptosis of Breast Cancer Cells, Inhibits Growth, and Distinguishes Malignant from Normal Phenotype in Three Dimensional Cultures and <i>In vivo</i>

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The multifaceted role of periostin in tumorigenesis

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Acquired Expression of Periostin by Human Breast Cancers Promotes Tumor Angiogenesis through Up-Regulation of Vascular Endothelial Growth Factor Receptor 2 Expression

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Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

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Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution

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Decorin

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Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells.

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Incorporation of Tenascin-C into the Extracellular Matrix by Periostin Underlies an Extracellular Meshwork Architecture

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The Hyaluronan Receptors CD44 and Rhamm (CD168) Form Complexes with ERK1,2 That Sustain High Basal Motility in Breast Cancer Cells

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Heparanase Enhances Syndecan-1 Shedding

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Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer.

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Remodeling of the Mammary Microenvironment after Lactation Promotes Breast Tumor Cell Metastasis

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