The DOI matches its Crossref record.
The Pulmonary Surfactant System: Biochemical and Clinical Aspects
Open accessAbstract
Abstract. This article starts with a brief account of the history of research on pulmonary surfactant. We will then discuss the morphological aspects and composition of the pulmonary surfactant system. We describe the hydrophilic surfactant proteins A and D and the hydrophobic surfactant proteins B and C, with focus on the crucial roles of these proteins in the dynamics, metabolism, and functions of pulmonary surfactant. Next we discuss the major disorders of the surfactant system. The final part of the review will be focused on the potentials and complications of surfactant therapy in the treatment of some of these disorders. It is our belief that increased knowledge of the surfactant system and its functions will lead to a more optimal composition of the exogenous surfactants and, perhaps, widen their applicability to treatment of surfactant disorders other than neonatal respiratory distress syndrome.
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Citations
Cited by
Cui, L., Zhou, Q.-F., Liao, C.-Y., Fu, J.-J., & Jiang, G.-B. (2009) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-008-9194-6 · Cited by 368
Controlled pulmonary drug and gene delivery using polymeric nano-carriers
Beck-Broichsitter, M., Merkel, O. M., & Kissel, T. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.004 · Cited by 200
Metadata
- Authors
- Creuwels, L. A. J. M., van Golde, L. M. G., & Haagsman, H. P.
- Venue
- Lung
- Published
- 1997-01
- Volume
- 175
- Issue
- 1
- Pages
- 1-39
- ISSN
- 0341-2040 (ISSN-L)
- 1432-1750
- OpenAlex
- W2106171015
- Cited by
- 304
- References
- 0
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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How to cite
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- CoChat. (2026). Citation check: The Pulmonary Surfactant System: Biochemical and Clinical Aspects. https://app.cochat.ai/papers/10.1007/pl00007554
- The paper
- Creuwels, L. A. J. M., van Golde, L. M. G., & Haagsman, H. P. (1997). The Pulmonary Surfactant System: Biochemical and Clinical Aspects. Lung. https://doi.org/10.1007/pl00007554
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
