Cited by 150Biochemical Acid Research StudiesMetabolism, Diabetes, and CancerMitochondrial Function and Pathology

The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.

Anaplerotic roles of pyruvate carboxylase in mammalian tissues

Open access

Jitrapakdee, S., Vidal-Puig, A., Wallace, J. C.·2006·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-005-5410-yPMC PMC11136034

Open this paper in CoChat — free account

Abstract

Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC serves an anaplerotic role for the tricarboxylic acid cycle, when intermediates are removed for different biosynthetic purposes. In liver and kidney, PC provides oxaloacetate for gluconeogenesis. In adipocytes PC is involved in de novo fatty acid synthesis and glyceroneogenesis, and is regulated by the peroxisome proliferator-activated receptor-gamma, suggesting that PC is involved in the metabolic switch controlling fuel partitioning toward lipogenesis. In islets, PC is necessary for glucose-induced insulin secretion by providing oxaloacetate to form malate that participates in the 'pyruvate/malate cycle' to shuttle 3C or 4C between mitochondria and cytoplasm. Hyperglycemia and hyperlipidemia impair this cycle and affect glucose-stimulated insulin release. In astrocytes, PC is important for de novo synthesis of glutamate, an important excitatory neurotransmitter supplied to neurons. Transcriptional studies of the PC gene pinpoint some transcription factors that determine tissue-specific expression.

Integrity signals

Registry

Crossref · 10.1007/s00018-005-5410-y

Cites

97 of 97 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440
Molecular Regulation of Adipogenesis
Rosen, E. D., & Spiegelman, B. M. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.145 · Cited by 1,310
Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
Shimabukuro, M., Zhou, Y.-T., Levi, M., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2498 · Cited by 1,142
Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells
Ashcroft, F. M., Harrison, D. E., & Ashcroft, S. J. H. (1984) · Nature · doi:10.1038/312446a0 · Cited by 1,113
Biochemistry and physiology of brain ammonia.
Cooper, A. J. L., & Plum, F. (1987) · Physiological Reviews · doi:10.1152/physrev.1987.67.2.440 · Cited by 841
Minireview: Secondary β-Cell Failure in Type 2 Diabetes—A Convergence of Glucotoxicity and Lipotoxicity
Poitout, V., & Robertson, R. P. (2002) · Endocrinology · doi:10.1210/endo.143.2.8623 · Cited by 743
A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm
Matschinsky, F. (1996) · Diabetes · doi:10.2337/diab.45.2.223 · Cited by 721
Defining the CREB Regulon
Impey, S., McCorkle, S., Cha‐Molstad, H., Dwyer, J. M., Yochum, G. S., Boss, J. M., McWeeney, S. K., Dunn, J. J., Mandel, G., & Goodman, R. H. (2004) · Cell · doi:10.1016/j.cell.2004.10.032 · Cited by 708
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616
Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes.
Student, A. K., Hsu, R. Y., & Lane, M. D. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85559-x · Cited by 590
METABOLIC COUPLING FACTORS IN PANCREATIC β-CELL SIGNAL TRANSDUCTION
Newgard, C. B., & McGarry, J. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003353 · Cited by 547
Astrocytic control of glutamatergic activity: astrocytes as stars of the show.
Hertz, L., & Zielke, H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.10.008 · Cited by 490
Glyceroneogenesis and the triglyceride/fatty acid cycle
Reshef, L., Olswang, Y., Cassuto, H., Blum, B., Croniger, C. M., Kalhan, S. C., Tilghman, S. M., & Hanson, R. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300017200 · Cited by 475
Pyruvate car☐ylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
Shank, R. P., Bennett, G. S., Freytag, S. O., & Campbell, G. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90552-9 · Cited by 471
Identification of Novel Phosphorylation Sites in Hormone-sensitive Lipase That Are Phosphorylated in Response to Isoproterenol and Govern Activation Properties in Vitro
Anthonsen, M. W., Rönnstrand, L., Wernstedt, C., Degerman, E., & Holm, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.215 · Cited by 468
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
Ishii, S., Iizuka, K., Miller, B. C., & Uyeda, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405238101 · Cited by 424
Metabolic Fate of Glucose in Purified Islet Cells
Schuit, F., De Vos, A., Farfari, S., Moens, K., Pipeleers, D., Brun, T., & Prentki, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18572 · Cited by 421
Pyruvate Carboxylase Activity in Primary Cultures of Astrocytes and Neurons
Yu, A. C., Drejer, J., Hertz, L., & Schousboe, A. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb00849.x · Cited by 406
Lipoapoptosis in Beta-cells of Obese Prediabeticfa/fa Rats
Shimabukuro, M., Higa, M., Zhou, Y.-T., Wang, M.-Y., Newgard, C. B., & Unger, R. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32487 · Cited by 394
Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion
Lang, J. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00043.x · Cited by 347
Induction of lipogenesis during differentiation in a "preadipocyte" cell line.
Mackall, J. C., Student, A. K., Polakis, S. E., & Lane, M. D. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)81883-3 · Cited by 316
Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects
Christensen, B., Arbour, L. T., Tran, P. V., Leclerc, D., Sabbaghian, N., Platt, R. W., Gilfix, B. M., Rosenblatt, D. S., Gravel, R. A., Forbes, P. A., et al. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990521)84:2 · Cited by 305
Feasibility of a Mitochondrial Pyruvate Malate Shuttle in Pancreatic Islets
MacDonald, M. J. (1995) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94588-6 · Cited by 274
13 C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)
Lu, D., Mulder, H., Zhao, P., Burgess, S. C., Jensen, M. V., Kamzolova, S. V., Newgard, C. B., & Sherry, A. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052005699 · Cited by 268
Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.
Farfari, S., Schulz, V., Corkey, B. E., & Prentki, M. (2000) · Diabetes · doi:10.2337/diabetes.49.5.718 · Cited by 266
Redox Control of Exocytosis
Ivarsson, R., Quintens, R., Dejonghe, S., Tsukamoto, K., in ’t Veld, P., Renström, E., & Schuit, F. C. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2132 · Cited by 265
Structure, function and regulation of pyruvate carboxylase
Jitrapakdee, S., & Wallace, J. C. (1999) · Biochemical Journal · doi:10.1042/bj3400001 · Cited by 242
Self-citation
Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion
MacDonald, M. J., Fahien, L. A., Brown, L. J., Hasan, N. M., Buss, J. D., & Kendrick, M. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00218.2004 · Cited by 241
Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell Function
Busch, A. K., Cordery, D. V., Denyer, G. S., & Biden, T. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.977 · Cited by 184
β-Cell Adaptation to Insulin Resistance
Liu, Y. Q., Jetton, T. L., & Leahy, J. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207157200 · Cited by 173
The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate
Ballard, F. J., & Hanson, R. W. (1967) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38917-3 · Cited by 166
Critical Reduction in β-Cell Mass Results in Two Distinct Outcomes over Time
Laybutt, D. R., Glandt, M., Xu, G., Ahn, Y. B., Trivedi, N., Bonner‐Weir, S., & Weir, G. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210581200 · Cited by 157
Evidence for an Anaplerotic/Malonyl-CoA Pathway in Pancreatic β-Cell Nutrient Signaling
Brun, T., Roche, E., Assimacopoulos-Jeannet, F., Corkey, B., Kim, K.-H., & Prentki, M. (1996) · Diabetes · doi:10.2337/diab.45.2.190 · Cited by 150
Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression.
Roche, E., Farfari, S., Witters, L. A., Assimacopoulos‐Jeannet, F., Thumelin, S., Brun, T., Corkey, B. E., Saha, A. K., & Prentki, M. (1998) · Diabetes · doi:10.2337/diabetes.47.7.1086 · Cited by 145
Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue
Boucher, A., Lu, D., Burgess, S. C., Telemaque-Potts, S., Jensen, M. V., Mulder, H., Wang, M.-Y., Unger, R. H., Sherry, A. D., & Newgard, C. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401167200 · Cited by 136
Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver
Hagopian, K. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00202-4 · Cited by 135
Liver X Receptor Activation Stimulates Insulin Secretion via Modulation of Glucose and Lipid Metabolism in Pancreatic Beta-Cells
Efanov, A. M., Sewing, S., Bokvist, K. B., & Gromada, J. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s75 · Cited by 135
Immunocytochemical Examination of Neural Rat and Mouse Primary Cultures Using Monoclonal Antibodies Raised Against Pyruvate Carboxylase
Cesar, M., & Hamprecht, B. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052312.x · Cited by 120
Role of pyruvate carboxylase in fatty acid synthesis: Alterations during preadipocyte differentiation
Mackall, J. C., & Lane, M. D. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)91171-8 · Cited by 109
Neuronal-astrocytic and cytosolic-mitochondrial metabolite trafficking during brain activation, hyperammonemia and energy deprivation
Hertz, L. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(00)00012-7 · Cited by 109
Role of Pyruvate Carboxylase in Facilitation of Synthesis of Glutamate and Glutamine in Cultured Astrocytes
Gamberino, W. C., Berkich, D. A., Lynch, C. J., Xu, B., & LaNoue, K. F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062312.x · Cited by 107
Glutamine-, glutamine synthetase-, glutamate dehydrogenase- and pyruvate carboxylase-immunoreactivities in the rat dorsal root ganglion and peripheral nerve
Miller, K. E., Richards, B. A., & Kriebel, R. M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02802-0 · Cited by 98
A Fatty Acid—Induced Decrease in Pyruvate Dehydrogenase Activity Is an Important Determinant of β-Cell Dysfunction in the Obese Diabetic db/db Mouse
Zhou, Y.-P., Berggren, P., & Grill, V. (1996) · Diabetes · doi:10.2337/diab.45.5.580 · Cited by 90
Quantifying the Carboxylation of Pyruvate in Pancreatic Islets
Khan, A., Ling, Z. C., & Landau, B. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2539 · Cited by 86
Estimates of Glycolysis, Pyruvate (De)Carboxylation, Pentose Phosphate Pathway, and Methyl Succinate Metabolism in Incapacitated Pancreatic Islets
MacDonald, M. J. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1413 · Cited by 83
The Peroxisome Proliferator-activated Receptor-γ Regulates Murine Pyruvate Carboxylase Gene Expression in Vivo and in Vitro
Jitrapakdee, S., Slawik, M., Medina‐Gómez, G., Campbell, M., Wallace, J. C., Sethi, J. K., O’Rahilly, S., & Vidal‐Puig, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503836200 · Cited by 82
Self-citation
Normalization by Insulin Treatment of Low Mitochondrial Glycerol Phosphate Dehydrogenase and Pyruvate Carboxylase in Pancreatic Islets of the GK Rat
MacDonald, M. J., Efendić, S., & Östenson, C. (1996) · Diabetes · doi:10.2337/diab.45.7.886 · Cited by 82
Carbon Dioxide Fixation in Neuronal and Astroglial Cells in Culture
Kaufman, E. E., & Driscoll, B. F. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09304.x · Cited by 78
In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase
Bahl, J. J., Matsuda, M., DeFronzo, R. A., & BRESSLER, R. C. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00660-0 · Cited by 77
Oligonucleotide Microarray Analysis Reveals PDX1 as an Essential Regulator of Mitochondrial Metabolism in Rat Islets
Gauthier, B. R., Brun, T., Sarret, E. J., Ishihara, H., Schaad, O., Descombes, P., & Wollheim, C. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405030200 · Cited by 72
Disorders of pyruvate carboxylase and the pyruvate dehydrogenase complex
Robinson, B. H., MacKay, N., Chun, K., & Ling, M. (1996) · Journal of Inherited Metabolic Disease · doi:10.1007/bf01799106 · Cited by 72
Lack of Glyconeogenesis in Pancreatic Islets: Expression of Gluconeogenic Enzyme Genes in Islets
MacDonald, M., McKenzie, D., Walker, T. M., & Kaysen, J. H. (1992) · Hormone and Metabolic Research · doi:10.1055/s-2007-1003284 · Cited by 68
Stimulus/Secretion Coupling Factors in Glucose-Stimulated Insulin Secretion
Newgard, C. B., Lu, D., Jensen, M. V., Schisler, J. C., Boucher, A., Burgess, S. C., & Sherry, A. D. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s389 · Cited by 67
The Succinate Mechanism of Insulin Release
Fahien, L. A., & MacDonald, M. J. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2669 · Cited by 66
Low Mitochondrial Glycerol Phosphate Dehydrogenase and Pyruvate Carboxylase in Pancreatic Islets of Zucker Diabetic Fatty Rats
MacDonald, M. J., Tang, J., & Polonsky, K. S. (1996) · Diabetes · doi:10.2337/diab.45.11.1626 · Cited by 63
Increasing Triglyceride Synthesis Inhibits Glucose-Induced Insulin Secretion in Isolated Rat Islets of Langerhans: A Study Using Adenoviral Expression of Diacylglycerol Acyltransferase
Kelpe, C. L., Johnson, L. M., & Poitout, V. (2002) · Endocrinology · doi:10.1210/en.2002-220402 · Cited by 63
Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.
Large, V., & Beylot, M. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1251 · Cited by 61
Formation of oxaloacetate from pyruvate and carbon dioxide.
Mf, U., & KEECH, D. B. (1960) · PubMed · Cited by 59
Pyruvate dehydrogenase and pyruvate carboxylase. Sites of pretranslational regulation by glucose of glucose-induced insulin release in pancreatic islets.
MacDonald, M. J., Kaysen, J. H., Moran, S. M., & Pomije, C. E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54585-3 · Cited by 59
The Physiological Role of Pyruvate Carboxylation in Hamster Brown Adipose Tissue
Cannon, B., & Nedergaard, J. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb12909.x · Cited by 59
Amerindian Pyruvate Carboxylase Deficiency Is Associated with Two Distinct Missense Mutations
Carbone, M. A., MacKay, N., Ling, M., Cole, D. E. C., Douglas, C. E., Rigat, B. A., Feigenbaum, A. J., Clarke, J. T. R., Haworth, J. C., Greenberg, C. R., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301884 · Cited by 57
The biochemical basis of increased hepatic glucose production in a mouse model of type 2 (non-insulin-dependent) diabetes mellitus
Andrikopoulos, S., & Proietto, J. (1995) · Diabetologia · doi:10.1007/bf00400598 · Cited by 56
Influence of Glucose on Pyruvate Carboxylase Expression in Pancreatic Islets
MacDonald, M. J. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1274 · Cited by 56
Regulation of Rat Pyruvate Carboxylase Gene Expression by Alternate Promoters during Development, in Genetically Obese Rats and in Insulin-secreting Cells
Jitrapakdee, S., Gong, Q., MacDonald, M. J., & Wallace, J. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34422 · Cited by 56
Self-citation
The Rat Pyruvate Carboxylase Gene Structure
Jitrapakdee, S., Booker, G. W., Cassady, A. I., & Wallace, J. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20522 · Cited by 56
Self-citation
Effect of streptozotocin-induced diabetes mellitus on the turnover of rat liver pyruvate carboxylase and pyruvate dehydrogenase
Weinberg, M. B., & Utter, M. F. (1980) · Biochemical Journal · doi:10.1042/bj1880601 · Cited by 55
Induction of pyruvate carboxylase apoenzyme and holoenzyme in 3T3-L1 cells during differentiation
Freytag, S. O., & Utter, M. F. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1321 · Cited by 54
Increased glucocorticoid sensitivity in islet beta-cells: effects on glucose 6-phosphatase, glucose cycling and insulin release
Ling, Z.-C., Khan, A. W., Delauny, F., Davani, B., Östenson, C., Gustafsson, J.-Α., Okret, S., Landau, B. R., & Efendić, S. (1998) · Diabetologia · doi:10.1007/s001250050961 · Cited by 52
A re-evaluation of the role of mitochondrial pyruvate transport in the hormonal control of rat liver mitochondrial pyruvate metabolism
Halestrap, A. P., & Armston, A. E. (1984) · Biochemical Journal · doi:10.1042/bj2230677 · Cited by 47
Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets.
Liu, Y. Q., Tornheim, K., & Leahy, J. L. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1747 · Cited by 45
Do Pancreatic Islets Contain Significant Amounts of Phosphoenolpyruvate Carboxykinase or Ferroactivator Activity?
MacDonald, M. J., & Chang, C.-M. (1985) · Diabetes · doi:10.2337/diab.34.3.246 · Cited by 44
The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesis
Owen, M. R., & Halestrap, A. P. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90079-u · Cited by 41
Essential role of citrate export from mitochondria at early differentiation stage of 3T3-L1 cells for their effective differentiation into fat cells, as revealed by studies using specific inhibitors of mitochondrial di- and tricarboxylate carriers
Kajimoto, K., Terada, H., Baba, Y., & Shinohara, Y. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.01.006 · Cited by 39
Metabolic consequence of long-term exposure of pancreatic β cells to free fatty acid with special reference to glucose insensitivity
Iizuka, K., Nakajima, H., Namba, M., Miyagawa, J.-I., Miyazaki, J., Hanafusa, T., & Matsuzawa, Y. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00082-5 · Cited by 37
Coordinate regulation of the biosynthesis of ATP-citrate lyase and malic enzyme during adipocyte differentiation. Studies on 3T3-L1 cells.
Wise, L. S., Sul, H. S., & Rubin, C. S. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42920-6 · Cited by 37
Chronic High Glucose Lowers Pyruvate Dehydrogenase Activity in Islets through Enhanced Production of Long Chain Acyl-CoA
Liu, Y. Q., Moibi, J. A., & Leahy, J. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307921200 · Cited by 36
Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA
Jitrapakdee, S., Adina-Zada, A., Besant, P. G., Surinya, K. H., Cleland, W. W., Wallace, J. C., & Attwood, P. V. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.03.016 · Cited by 35
Self-citation
Hyperglycemia contributes to impaired insulin response in GK rat islets.
Ling, Z. C., Hong-Lie, C., Östenson, C.-G., Efendić, S., & Khan, A. W. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s108 · Cited by 35
Interaction of Tumor Necrosis Factor-α- and Thiazolidinedione-Regulated Pathways in Obesity
Wellen, K. E., Uysal, K. T., Wiesbrock, S. M., Yang, Q., Chen, H., & Hotamışlıgil, G. S. (2004) · Endocrinology · doi:10.1210/en.2003-1580 · Cited by 33
Pyruvate carboxylase in genetic obesity
Lynch, C. J., McCall, K. M., Billingsley, M. L., Bohlen, L. M., Hreniuk, S. P., Martin, L. F., Witters, L. A., & Vannucci, S. J. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.5.e608 · Cited by 29
Structural and Promoter Regions of the Murine Pyruvate Carboxylase Gene
Jitrapakdee, S., Petchamphai, N., Sunyakumthorn, P., Wallace, J. C., & Boonsaeng, V. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5599 · Cited by 23
Self-citation
Erratum: A mathematical model of compartmentalized neurotransmitter metabolism in the human brain (American Journal of Physiology - Endocrinology and Metabolism (July 2001) 281 (E100-E112))
Gruetter, R., Seaquist, E. R., & Uǧurbil, K. (2004) · Cited by 23
Increase in translatable mRNA for mitochondrial pyruvate carboxylase during differentiation of 3T3 preadipocytes
Angus, C., Lane, M. D., Rosenfeld, P. J., & Kelly, T. J. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)90252-7 · Cited by 21
Effect of Carbonic Anhydrase Inhibition and Acetoacetate on Anaplerotic Pyruvate Carboxylase Activity in Cultured Rat Astrocytes
Hazen, S. A., Waheed, A., Sly, W. S., LaNoue, K. F., & Lynch, C. J. (1997) · Developmental Neuroscience · doi:10.1159/000111202 · Cited by 21
Enhanced rat β-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway
Liu, Y. Q., Han, J., Epstein, P. N., & Long, Y. S. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00427.2004 · Cited by 19
The stimulation of mitochondrial pyruvate carboxylation after dexamethasone treatment of rats
Martin, A. D., Allan, E. H., & Titheradge, M. A. (1984) · Biochemical Journal · doi:10.1042/bj2190107 · Cited by 18
Involvement of specific proteins (Sp1/Sp3) and nuclear factor Y in basal transcription of the distal promoter of the rat pyruvate carboxylase gene in β-cells
Sunyakumthorn, P., Boonsaen, T., Boonsaeng, V., Wallace, J. C., & Jitrapakdee, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.108 · Cited by 17
Self-citation
Regulation of the activity and synthesis of malic enzyme in 3T3-L1 cells
Goodridge, A. G., Fisch, J. E., & Glynias, M. J. (1984) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(84)90046-8 · Cited by 16
Evidence that increased glucose cycling in islets of diabetic ob/ob mice is a primary feature of the disease
Khan, A. W., & Efendić, S. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.4.e623 · Cited by 15
Metabolic consequences of limited substrate anion permeability in brown fat mitochondria from a hibernator, the golden hamster
Cannon, B., BERNSON, V. S. M., & Nedergaard, J. (1984) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(84)90264-0 · Cited by 14
Hexose metabolism in pancreatic islets: pyruvate carboxylase activity
Curi, R., Carpinelli, Â. R., & Malaisse, W. J. (1991) · Biochimie · doi:10.1016/0300-9084(91)90026-w · Cited by 13
Quantification of glucose cycling and the extent of equilibration of glucose 6-phosphate with fructose 6-phosphate in islets from ob/ob mice
Chandramouli, V., Khan, A. W., Östenson, C., Berggren, P., Löw, H., Landau, B. R., & Efendić, S. (1991) · Biochemical Journal · doi:10.1042/bj2780353 · Cited by 8
Evidence for the expression of both the hydrolase and translocase components of hepatic glucose-6-phosphatase in murine pancreatic islets
Goh, B.-H., Efendić, S., Khan, A., & Portwood, N. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01242-7 · Cited by 3

Sorted by citations

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
Leone, R. D., Zhao, L., Englert, J. M., Sun, I.-M., Oh, M.-H., Sun, I.-H., Arwood, M. L., Bettencourt, I. A., Patel, C. H., Wen, J., et al. (2019) · Science · doi:10.1126/science.aav2588 · Cited by 1,169
Lactate: the ugly duckling of energy metabolism
Rabinowitz, J. D., & Enerbäck, S. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0243-4 · Cited by 1,140
Glutamine reliance in cell metabolism
Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021
Reprogramming of the Circadian Clock by Nutritional Challenge
Eckel‐Mahan, K. L., Patel, V. R., de Mateo, S., Orozco-Solís, R., Ceglia, N., Sahar, S., Dilag-Penilla, S. A., Dyar, K. A., Baldi, P., & Sassone‐Corsi, P. (2013) · Cell · doi:10.1016/j.cell.2013.11.034 · Cited by 737
Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation
Lee, S. Y., Jeong, E. K., Ju, M. K., Jeon, H. M., Kim, M. Y., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2017) · Molecular Cancer · doi:10.1186/s12943-016-0577-4 · Cited by 592

See all 150

Authors: Jitrapakdee, S., Vidal-Puig, A., & Wallace, J. C.
Affiliations: Mahidol University (TH)
The University of Adelaide (AU)
Corresponding author: Jitrapakdee, S.
ORCID: Jitrapakdee, S.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2006-02-28
Volume: 63
Issue: 7-8
Pages: 843-854
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-005-5410-y
PMC: PMC11136034
OpenAlex: W1986860566
Cited by: 149
References: 97
Citations by year: 2026: 5 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 2 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 9 · 2017: 3 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 12 · 2012: 12
FWCI: 2.87
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: pyruvate carboxylase, anaplerosis, TCA cycle, oxaloacetate, gluconeogenesis, fatty acid synthesis, glyceroneogenesis, PPARγ, metabolic switch, lipogenesis, glucose-stimulated insulin secretion, malate, islets, astrocytes, glutamate synthesis, hyperglycemia, hyperlipidemia, tissue-specific gene expression, transcription factors
MeSH terms: Animals, Humans, Kidney, Liver, Pancreas, Pyruvate Carboxylase, Signal Transduction, Pyruvic Acid, Oxaloacetic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Anaplerotic roles of pyruvate carboxylase in mammalian tissues

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks