Glyceroneogenesis and the triglyceride/fatty acid cycle

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,253 · see citing works

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

Ashrafi, K., Chang, F., Watts, J. L., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature · doi:10.1038/nature01279 · Cited by 972 · see citing works

REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSION

Hanson, R. W., & Reshef, L. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.581 · Cited by 729 · see citing works

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

Tontonoz, P., Hu, E., Devine, J. H., BEALE, E. G., & Spiegelman, B. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.351 · Cited by 559 · see citing works

Effect of Severe Burn Injury on Substrate Cycling by Glucose and Fatty Acids

Wolfe, R. R., Herndon, D. N., Jahoor, F., Miyoshi, H., & Wolfe, M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708133170702 · Cited by 467 · see citing works

Glycerol Utilization and its Regulation in Mammals

Lin, E. C. C. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.004001 · Cited by 431 · see citing works

The Production and Release of Glycerol by Adipose Tissue Incubated in Vitro

Vaughan, M. M. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70821-7 · Cited by 428 · see citing works

A futile metabolic cycle activated in adipocytes by antidiabetic agents

Guan, H.-P., Li, Y., Jensen, M. V., Newgard, C. B., Steppan, C. M., & Lazar, M. A. (2002) · Nature Medicine · doi:10.1038/nm780 · Cited by 427 · see citing works

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR7 and RXRa

Tontonoz, P., Graves, R. A., Budavari, A. I., Erdjument‐Bromage, H., Lui, M., Hu, E., Tempst, P., & Spiegelman, B. M. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.25.5628 · Cited by 383 · see citing works

THE EFFECTS OF ADRENALECTOMY AND HYPOPHYSECTOMY UPON EXPERIMENTAL DIABETES IN THE CAT

Long, C. N. H., & LUKENS, F. D. W. (1936) · The Journal of Experimental Medicine · doi:10.1084/jem.63.4.465 · Cited by 273 · see citing works

Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism

She, P., Shiota, M., Shelton, K. D., Chalkley, R. G., Postic, C., & Magnuson, M. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6508-6517.2000 · Cited by 257 · see citing works

Increased Fatty Acid Re-esterification by PEPCK Overexpression in Adipose Tissue Leads to Obesity Without Insulin Resistance

Franckhauser, S., MUÑOZ, S. A., Pujol, A., Casellas, A., Riu, E., Otaegui, P. J., Su, B., & Bosch, F. (2002) · Diabetes · doi:10.2337/diabetes.51.3.624 · Cited by 233 · see citing works

Phosphoenolpyruvate Carboxykinase and the Synthesis of Glyceride-Glycerol from Pyruvate in Adipose Tissue

Ballard, F. J., Hanson, R. W., & Leveille, G. A. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99631-6 · Cited by 206 · see citing works

Thiazolidinediones Block Fatty Acid Release by Inducing Glyceroneogenesis in Fat Cells

Tordjman, J., Chauvet, G., Quette, J., BEALE, E. G., Forest, C. D., & Antoine, B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206999200 · Cited by 177 · see citing works

A Possible Physiological Role for Glyceroneogenesis in Rat Adipose Tissue

Reshef, L., Hanson, R. W., & Ballard, F. J. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62651-1 · Cited by 171 · see citing works

A mutation in the peroxisome proliferator-activated receptor γ-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice

Olswang, Y., Cohen, H., Papo, O., Cassuto, H., Croniger, C. M., Hakimi, P., Tilghman, S. M., Hanson, R. W., & Reshef, L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022616299 · Cited by 137 · see citing works

Development of brown and white adipose tissue

Hahn, P., & Novák, M. (1975) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36732-8 · Cited by 115 · see citing works

The energy cost of triglyceride-fatty acid recycling in nonobese subjects after an overnight fast and four days of starvation

Elia, M., Zed, C., Neale, G., & Livesey, G. (1987) · Metabolism · doi:10.1016/0026-0495(87)90184-3 · Cited by 113 · see citing works

Triglyceride/fatty acid cycling is increased after exercise

Bahr, R., Hansson, P., & Sejersted, O. M. (1990) · Metabolism · doi:10.1016/0026-0495(90)90313-2 · Cited by 108 · see citing works

Glyceride-Glycerol Synthesis from Pyruvate

Reshef, L., Hanson, R. W., & Ballard, F. J. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94358-9 · Cited by 107 · see citing works

Glyceroneogenesis and the Source of Glycerol for Hepatic Triacylglycerol Synthesis in Humans

Kalhan, S. C., Mahajan, S. D., Burkett, E., Reshef, L., & Hanson, R. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006186200 · Cited by 96 · see citing works

Adipose Expression of the Phosphoenolpyruvate Carboxykinase Promoter Requires Peroxisome Proliferator-activated Receptor γ and 9-cis-Retinoic Acid Receptor Binding to an Adipocyte-specific Enhancer in Vivo

Devine, J. H., Eubank, D. W., Clouthier, D. E., Tontonoz, P., Spiegelman, B. M., Hammer, R. E., & BEALE, E. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13604 · Cited by 88 · see citing works

Effect of hormones on transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat kidney

Meisner, H. M., Loose, D. S., & Hanson, R. W. (1985) · Biochemistry · doi:10.1021/bi00323a027 · Cited by 82 · see citing works

Whole-body lipolysis and triglyceride-fatty acid cycling in cachectic patients with esophageal cancer.

Klein, S., & Wolfe, R. R. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114854 · Cited by 82 · see citing works

Blood Glycerol Is an Important Precursor for Intramuscular Triacylglycerol Synthesis

Guo, Z., & Jensen, M. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23702 · Cited by 79 · see citing works

Glucocorticoids control phosphoenolpyruvate carboxykinase gene expression in a tissue specific manner

Nechushtan, H., Benvenisty, N., Brandeis, R., et al. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.16.6405 · Cited by 77 · see citing works

Glycerol Metabolism and Triglyceride-Fatty Acid Cycling in the Human Newborn: Effect of Maternal Diabetes and Intrauterine Growth Retardation

Patel, D. M., & Kalhan, S. C. (1992) · Pediatric Research · doi:10.1203/00006450-199201000-00010 · Cited by 75 · see citing works

Glyceroneogenesis in Adipose Tissue of Fasted, Diabetic and Triamcinolone Treated Rats

Gorin, E., Talor, Z., & Shafrir, E. (1969) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1969.tb00537.x · Cited by 69 · see citing works

Glyceroneogenesis comes of age

BEALE, E. G., Hammer, R. E., Antoine, B., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0407rev · Cited by 63 · see citing works

Stimulation of apolipoprotein secretion in very-low-density and high-density lipoproteins from cultured rat hepatocytes by dexamethasone

Martín‐Sanz, P., Vance, J. E., & Brindley, D. N. (1990) · Biochemical Journal · doi:10.1042/bj2710575 · Cited by 63 · see citing works

ADVANCEMENT OF KNOWLEDGE OF THE RôLE OF THE HYPOPHYSIS IN CARBOHYDRATE METABOLISM DURING THE LAST TWENTY-FIVE YEARS

Houssay, B. A. (1942) · Endocrinology · doi:10.1210/endo-30-6-884 · Cited by 62 · see citing works

A single element in the phosphoenolpyruvate carboxykinase gene mediates thiazolidinedione action specifically in adipocytes

Glorian, M., Duplus, E., BEALE, E. G., Scott, D. K., Granner, D. K., & Forest, C. D. (2001) · Biochimie · doi:10.1016/s0300-9084(01)01343-8 · Cited by 60 · see citing works

Glucose contribution to in vivo synthesis of glyceride-glycerol and fatty acids in rats adapted to a high-protein, carbohydrate-free diet

Botion, L. M., Brito, M. N., Brito, N. A., Brito, S. R. C., Kettelhut, Í. D. C., & Migliorini, R. H. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90326-2 · Cited by 56 · see citing works

The Role of the Adrenals in the Regulation of Phosphoenolpyruvate Carboxykinase of Rat Adipose Tissue

Reshef, L., Ballard, F. J., & Hanson, R. W. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63600-2 · Cited by 42 · see citing works

Glucocorticoids Repress Transcription of Phosphoenolpyruvate Carboxykinase (GTP) Gene in Adipocytes by Inhibiting Its C/EBP-mediated Activation

Olswang, Y., Blum, B., Cassuto, H., Cohen, H., Biberman, Y., Hanson, R. W., & Reshef, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300263200 · Cited by 39 · see citing works

Peroxisome Proliferator-activated Receptor γ and Chicken Ovalbumin Upstream Promoter Transcription Factor II Negatively Regulate the Phosphoenolpyruvate Carboxykinase Promoter via a Common Element*

Eubank, D. W., Duplus, E., Williams, S. C., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103019200 · Cited by 38 · see citing works

Regulation of phosphoenolpyruvate carboxykinase (GTP) in adipose tissue in vivo by glucocorticoids and insulin

Meyuhas, O., Reshef, L., Gunn, J. M., et al. (1976) · Biochemical Journal · doi:10.1042/bj1580001 · Cited by 37 · see citing works

Thermogenic Capacity of Brown Adipose Tissue Is Reduced in Rats Fed a High Protein, Carbohydrate-Free Diet

Brito, M. N., Brito, N. A., & Migliorini, R. H. (1992) · Journal of Nutrition · doi:10.1093/jn/122.11.2081 · Cited by 37 · see citing works

The interaction of catecholamines and adrenal corticosteroids in the induction of phosphopyruvate carboxylase in rat liver and adipose tissue

Reshef, L., & Hanson, R. W. (1972) · Biochemical Journal · doi:10.1042/bj1270809 · Cited by 36 · see citing works

Mouse models of lipodystrophy

Reue, K., & Péterfy, M. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0077-1 · Cited by 34 · see citing works

Effect of propionate on pyruvate metabolism in adipose tissue

Reshef, L., Niv, J., & Shapiro, B. (1967) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38893-3 · Cited by 32 · see citing works

Predominant expression of the mitochondrial dicarboxylate carrier in white adipose tissue

Das, K., Lewis, R. Y., COMBATSIARIS, T. P., Lin, Y. L., Shapiro, L. S., Charron, M. J., & Scherer, P. E. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3440313 · Cited by 32 · see citing works

The effect of insulin and glucocorticoids on the synthesis and degradation of phosphoenolpyruvate carboxykinase (GTP) in rat adipose tissue cultured in vitro

Meyuhas, O., Reshef, L., Ballard, F. J., et al. (1976) · Biochemical Journal · doi:10.1042/bj1580009 · Cited by 26 · see citing works

Predominant expression of the mitochondrial dicarboxylate carrier in white adipose tissue

Das, K., Lewis, R. Y., COMBATSIARIS, T. P., et al. (1999) · Biochemical Journal · doi:10.1042/bj3440313 · Cited by 26 · see citing works

The Effects of Catecholamines, Glucagon, and Diet on Enzyme Activities in Brown Fat and Liver of the Rat

Hahn, P., & Kirby, L. T. (1974) · Canadian Journal of Biochemistry · doi:10.1139/o74-105 · Cited by 25 · see citing works

The Effect of 3,5,3′-Triiodothyronine on Phosphoenolpyruvate Carboxykinase, Fatty Acid Synthetase and Malic Enzyme Activity of Liver and Brown Fat of Fetal and Neonatal Rats

Hahn, P., & Hassanali, S. (2009) · Biology of the Neonate · doi:10.1159/000241509 · Cited by 16 · see citing works

Metabolic Flexibility in Health and Disease

Goodpaster, B. H., & Sparks, L. M. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.015 · Cited by 995 · see citing works

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works

Glucocorticoids, metabolism and metabolic diseases

Vegiopoulos, A., & Herzig, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.015 · Cited by 535 · see citing works

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442 · see citing works

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review

Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works

Integrative metabolism in MASLD and MASH: Pathophysiology and emerging mechanisms

Steinberg, G. R., Valvano, C. M., De Nardo, W., & Watt, M. J. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.02.033 · Cited by 240 · see citing works

Anaplerotic roles of pyruvate carboxylase in mammalian tissues

Jitrapakdee, S., Vidal-Puig, A., & Wallace, J. C. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5410-y · Cited by 149 · see citing works

Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

Chutkow, W. A., Birkenfeld, A. L., Brown, J. D., Lee, H.-Y., Frederick, D. W., Yoshioka, J., Patwari, P., Kursawe, R., Cushman, S. W., Plutzky, J., et al. (2010) · Diabetes · doi:10.2337/db09-1212 · Cited by 142 · see citing works

Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells.

Shi, X., Burkart, A., Nicoloro, S. M., Czech, M. P., Straubhaar, J., & Corvera, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800510200 · Cited by 70 · see citing works

Revisiting the diacylglycerol-induced insulin resistance hypothesis

Amati, F. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01036.x · Cited by 59 · see citing works

Cold acclimation enhances UCP1 content, lipolysis, and triacylglycerol resynthesis, but not mitochondrial uncoupling and fat oxidation, in rat white adipocytes

Sepa-Kishi, D. M., Jani, S., Da Eira, D., & Ceddia, R. B. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00122.2018 · Cited by 39 · see citing works

Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males.

Riis, S., Christensen, B., Nellemann, B., Møller, A. B., Husted, A. S., Pedersen, S. B., Schwartz, T. W., Jørgensen, J. O. L., & Jessen, N. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00989.2018 · Cited by 39 · see citing works

LB-OR-5 THE ROLE OF ADIPOSE TRIGLYCERIDE LIPASE (ATGL) IN HUMAN ADIPOSE TISSUE LIPOLYSIS

Schweiger, M., Schoiswohl, G., Lass, A., et al. (2007) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(07)71866-4

Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis

Rydén, M., Jocken, J. W. E., van Harmelen, V., Dicker, A., Hoffstedt, J., Wirén, M., Blomqvist, L., Mairal, A., Langin, D., Blaak, E. E., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00040.2007 · Cited by 138 · see citing works

Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Lipolysis in hMADS Adipocytes

Bézaire, V., Mairal, A., Ribet, C., Lefort, C., Girousse, A., Jocken, J. W. E., Laurencikiene, J., Anesia, R., Rodriguez, A., Rydén, M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008631 · Cited by 219 · see citing works

Lipid metabolism and exercise

Hashimoto, T. (2013) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.2.149 · Cited by 2 · see citing works

Glucocorticoids increase basal lipolysis, but not epinephrine stimulated lipolysis

Campbell, J. E., Hawke, T. J., & Riddell, M. C. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.991.13