The DOI matches its Crossref record; 187 of the 187 references it cites were found in a registry or an index.
New insights into the molecular mechanisms of sperm-egg interaction
Open accessAbstract
At the moment of insemination millions of mammalian sperm cells are released into the female reproductive tract in order to find a single cell - the oocyte. The spermatozoa subsequently ignore the thousands of cells they make contact with during their journey to the site of fertilisation, until they reach the surface of the oocyte. At this point, they bind tenaciously to the acellular coat, known as the zona pellucida, that surrounds the oocyte and initiate the chain of cellular interactions that will culminate in fertilization. These exquisitely cell- and species-specific recognition events are among the most strategically important cellular interactions in biology. Understanding the cellular and molecular mechanisms that underpin them has implications for diagnosis of the aetiology of human infertility and the development of novel targets for fertility regulation. Herein, we describe two models indicating the plethora of highly orchestrated molecular interactions underlying successful sperm zona binding and sperm oocyte fusion.
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“Orthologues of many of the eutherian sperm membrane proteins related to fertilization 40 are present in platypus (and marsupial) genomes.”
From Genome analysis of the platypus reveals unique signatures of evolution (2008) · cites this paper as [40]
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Citations
Cites
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Cited by
Sorted by citations
Genome analysis of the platypus reveals unique signatures of evolution
paper, A. L. O. A. A. T. A. A. A. T. E. O. T. (2008) · Nature · doi:10.1038/nature06936 · Cited by 719
Redgrove, K. A., Nixon, B., Baker, M. A., Hetherington, L., Baker, G., Liu, D.-Y., & Aitken, R. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050851 · Cited by 142
Self-citationThe Chaperonin Containing TCP1 Complex (CCT/TRiC) Is Involved in Mediating Sperm-Oocyte Interaction
Dun, M. D., Smith, N. D., Baker, M. A., Lin, M., Aitken, R. J., & Nixon, B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.188888 · Cited by 126
Self-citationCauses and consequences of the evolution of reproductive proteins
Turner, L. M., & Hoekstra, H. E. (2008) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082577lt · Cited by 125
Mouse models in male fertility research
Jamsai, D., & O’Bryan, M. K. (2010) · Asian Journal of Andrology · doi:10.1038/aja.2010.101 · Cited by 130
Metadata
- Authors
- Nixon, B., Aitken, R. J., & McLaughlin, E. A.
- Affiliations
- University of Newcastle Australia (AU)
- Corresponding author
- Aitken, R. J.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2007-04-20
- Volume
- 64
- Issue
- 14
- Pages
- 1805-1823
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11136410
- OpenAlex
- W1980008727
- Cited by
- 103
- References
- 187
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 10
- FWCI
- 15.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- sperm-egg interaction, fertilisation (biology), zona pellucida, sperm-egg binding, sperm-egg fusion, sperm-egg recognition, species-specific recognition, infertility, fertility control, oocytes
- MeSH terms
- Animals, Female, Fertilization, Male, Models, Biological, Oocytes, Proteins, Sperm Capacitation, Sperm Maturation, Sperm-Ovum Interactions, Spermatozoa, Zona Pellucida, Membrane Microdomains, Systems Biology, Mice
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