Cited by 103Sperm and Testicular FunctionReproductive Biology and FertilityReproductive biology and impacts on aquatic species

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New insights into the molecular mechanisms of sperm-egg interaction

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Nixon, B., Aitken, R. J., McLaughlin, E. A.·2007·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-007-6552-xPMC PMC11136410

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Abstract

At the moment of insemination millions of mammalian sperm cells are released into the female reproductive tract in order to find a single cell - the oocyte. The spermatozoa subsequently ignore the thousands of cells they make contact with during their journey to the site of fertilisation, until they reach the surface of the oocyte. At this point, they bind tenaciously to the acellular coat, known as the zona pellucida, that surrounds the oocyte and initiate the chain of cellular interactions that will culminate in fertilization. These exquisitely cell- and species-specific recognition events are among the most strategically important cellular interactions in biology. Understanding the cellular and molecular mechanisms that underpin them has implications for diagnosis of the aetiology of human infertility and the development of novel targets for fertility regulation. Herein, we describe two models indicating the plethora of highly orchestrated molecular interactions underlying successful sperm zona binding and sperm oocyte fusion.

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The Lymphocyte Metalloprotease MDC-L (ADAM 28) Is a Ligand for the Integrin α4β1
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Direct Binding of the Ligand PSG17 to CD9 Requires a CD9 Site Essential for Sperm-Egg Fusion
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Increased telomere size in sperm cells of mammals with long terminal (TTAGGG)n arrays
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O-Linked Trisaccharide and N-Linked Poly-N-Acetyllactosaminyl Glycans are Present on Mouse ZP2 and ZP31
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Capacitation dependent activation of tyrosine phosphorylation generates two sperm head plasma membrane proteins with high primary binding affinity for the zona pellucida
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Male Germ Cell‐Expressed Mouse Gene TAZ83 Encodes a Putative, Cysteine‐rich Transmembrane Protein (cyritestin) Sharing Homologies with Snake Toxins and Sperm‐Egg Fusion Proteins
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Purified and Refolded Recombinant Bonnet Monkey (Macaca radiata) Zona Pellucida Glycoprotein-B Expressed in Escherichia coli Binds to Spermatozoa1
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Authors: Nixon, B., Aitken, R. J., & McLaughlin, E. A.
Affiliations: University of Newcastle Australia (AU)
Corresponding author: Aitken, R. J.
ORCID: Nixon, B.
Aitken, R. J.
McLaughlin, E. A.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2007-04-20
Volume: 64
Issue: 14
Pages: 1805-1823
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-007-6552-x
PMC: PMC11136410
OpenAlex: W1980008727
Cited by: 103
References: 187
Citations by year: 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 10
FWCI: 15.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
Keywords: sperm-egg interaction, fertilisation (biology), zona pellucida, sperm-egg binding, sperm-egg fusion, sperm-egg recognition, species-specific recognition, infertility, fertility control, oocytes
MeSH terms: Animals, Female, Fertilization, Male, Models, Biological, Oocytes, Proteins, Sperm Capacitation, Sperm Maturation, Sperm-Ovum Interactions, Spermatozoa, Zona Pellucida, Membrane Microdomains, Systems Biology, Mice

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New insights into the molecular mechanisms of sperm-egg interaction

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