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Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain
Open accessAbstract
Small conductance calcium-activated potassium (SK or K(Ca)2) channels link intracellular calcium transients to membrane potential changes. SK channel subtypes present different pharmacology and distribution in the nervous system. The selective blocker apamin, SK enhancers and mice lacking specific SK channel subunits have revealed multifaceted functions of these channels in neurons, glia and cerebral blood vessels. SK channels regulate neuronal firing by contributing to the afterhyperpolarization following action potentials and mediating I(AHP), and partake in a calcium-mediated feedback loop with NMDA receptors, controlling the threshold for induction of hippocampal long-term potentiation. The function of distinct SK channel subtypes in different neurons often results from their specific coupling to different calcium sources. The prominent role of SK channels in the modulation of excitability and synaptic function of limbic, dopaminergic and cerebellar neurons hints at their possible involvement in neuronal dysfunction, either as part of the causal mechanism or as potential therapeutic targets.
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![Figure 1 Sequence alignment of the human small conductance Ca2+-activated K+ channels hSK1, hSK2 and hSK3. The putative transmembrane spanning regions, S1–S6, are boxed in gray. The pore region (P-Region) is boxed in turquoise. The calmodulin-binding domain (CaMBD) is indicated by black bars. Amino acids corresponding to phosphorylation consensus sequences for the cyclic AMP- and cyclic GMP-dependent kinases (PKA and PKG) are displayed in red, for protein kinase C (PKC) in blue; and for casein kinase 2 (CK2) boxed in orange. Only intracellular phosphorylation consensus sequences have been labeled for PKA, PKG and PKC, while both intra- and extracellular ones have been highlighted for CK2 because of its potential action as an endo- and ectokinase [263]. Phosphorylation consensus sites have been mapped using the Prosite database: for PKA/PKG: PS00004: [RK](2)-x-[ST]; for PKC: PS00005: [ST]-x-[RK]; for CK2: PS00006: [ST]-x(2)-[DE].](/paper-figures/aaef1bf94b5446dc835b65f8b53f9b28/molecular-and-cellular-basis-of-small-and-intermediate-conductance-calcium-figure-1.jpg)
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“Particularly, small-conductance calcium-activated potassium (SK) channels have been reported to control the spontaneous firing regularity both in vivo and in vitro [80, 81].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [80]
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Items 201–266 of 266
Protein kinase CK2 as an ectokinase: The role of the regulatory CK2β subunit
Rodríguez, F. A., Contreras, C. F., Bolaños-García, V. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802065105 · Cited by 45
Scuvée‐Moreau, J., Boland, A., Graulich, A., et al. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705979 · Cited by 44
An Apamin- and Scyllatoxin-Insensitive Isoform of the Human SK3 Channel
Wittekindt, O. H., Visan, V., Tomita, H., Imtiaz, F., Gargus, J. J., Lehmann‐Horn, F., Grissmer, S., & Morris-Rosendahl, D. J. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.3.788 · Cited by 44
Yamada, S., Takechi, H., Kanchiku, I., Kita, T., & Kato, N. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01049.2003 · Cited by 44
Rimini, R., Rimland, J. M., & Terstappen, G. C. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00255-2 · Cited by 44
Novel 384-Well Population Patch Clamp Electrophysiology Assays for Ca2+-Activated K+ Channels
John, V. H., Dale, T., Hollands, E. C., et al. (2006) · SLAS DISCOVERY · doi:10.1177/1087057106294920 · Cited by 43
Gallo, G., Ernst, A. F., McLoon, S. C., & Letourneau, P. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05016.2002 · Cited by 43
Wittekindt, O. H., Jauch, A. S., Burgert, E., et al. (1998) · Neurogenetics · doi:10.1007/s100480050038 · Cited by 41
Domain Analysis of the Calcium-activated Potassium Channel SK1 from Rat Brain
D’hoedt, D., Hirzel, K., Pedarzani, P., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300382200 · Cited by 39
Self-citationResponses of cerebral arterioles to ADP: eNOS-dependent and eNOS-independent mechanisms
Faraci, F. M., Lynch, C. M., & Lamping, K. G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00392.2004 · Cited by 39
Terstappen, G. C., Pellacani, A., Aldegheri, L., et al. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00574-3 · Cited by 39
Short CAG repeats within the hSKCa3 gene associated with schizophrenia
Stöber, G., Jatzke, S., Meyer, J., Okladnova, O., Knapp, M., Beckmann, H., & Lesch, K. (1998) · Neuroreport · doi:10.1097/00001756-199811160-00010 · Cited by 39
Roncarati, R., Chio, M. D., Sava, A., Terstappen, G. C., & Fumagalli, G. F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00066-5 · Cited by 37
Activation of SK channels inhibits epileptiform bursting in hippocampal CA3 neurons
Lappin, S. C., Dale, T., Brown, J. T., Trezise, D. J., & Davies, C. H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.024 · Cited by 37
Bonnet‐Brilhault, F., Laurent‐Levinson, C., Campion, D., et al. (1999) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200278 · Cited by 36
Fajloun, Z., Carlier, E., Lecomte-Pradines, C., et al. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01577.x · Cited by 35
Mutation screening of the KCNN3 gene reveals a rare frameshift mutation
Bowen, T., Williams, N., Norton, N., et al. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000128 · Cited by 34
An association of CAG repeats at the KCNN3 locus with symptom dimensions of schizophrenia
Ritsner, M. S., Modai, I., Ziv, H., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01348-8 · Cited by 34
Seutin, V., Mkahli, F., Massotte, L., & Dresse, A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.1.192 · Cited by 34
Lecomte-Pradines, C., Ferrat, G., Fajloun, Z., et al. (1999) · Journal of Peptide Research · doi:10.1034/j.1399-3011.1999.00107.x · Cited by 33
Johnson, W. G. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990820)88:4 · Cited by 33
Li, T., Hu, X., Chandy, K. G., Fantino, E., Kálmán, K., Gutman, G. A., Gargus, J. J., Freeman, B., Murray, R. M., Dawson, E., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9484 · Cited by 32
Austin, C. P., Holder, D. J., Ma, L., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000548 · Cited by 32
1-Ethyl-2-benzimidazolinone (EBIO) suppresses epileptiform activity in in vitro hippocampus
Garduño, J., Galván, E. J., de Sevilla, D. F., & Buño, W. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.03.021 · Cited by 31
Gu, X., Blatz, A. L., & German, D. C. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90044-x · Cited by 31
Hawi, Z., Mynett-Johnson, L., Murphy, V., Straub, R., Kendler, K., Walsh, D., Mckeon, P., & Gill, M. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000560 · Cited by 29
A piece in the puzzle: an ion channel candidate gene for schizophrenia
Gargus, J. J., Fantino, E., & Gutman, G. A. (1998) · Molecular Medicine Today · doi:10.1016/s1357-4310(98)01358-6 · Cited by 29
Intermediate conductance potassium (IK) channels occur in human enteric neurons
Furness, J. B., Kearney, K., Robbins, H. L., Hunne, B., Selmer, I.-S., Neylon, C. B., Chen, M. X., & Tjandra, J. J. (2004) · Autonomic Neuroscience · doi:10.1016/j.autneu.2004.02.003 · Cited by 29
Cai, X., Wei, D.-S., Gallagher, S. E., Bagal, A. A., Mei, Y., Kao, J. P. Y., Thompson, S. M., & Tang, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4502-06.2007 · Cited by 28
Dale, T., Cryan, J. F., Chen, M., et al. (2002) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-002-0622-2 · Cited by 28
Yanovsky, Y., Zhang, W., & Misgeld, U. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.026 · Cited by 28
Molecular BKology: The Study of Splicing and Dicing
Fury, M. G., Marx, S. O., & Marks, A. R. (2002) · Science s STKE · doi:10.1126/stke.2002.123.pe12 · Cited by 27
Koronyo‐Hamaoui, M., Frisch, A., STEIN, D., DENZIGER, Y., Leor, S., Michaelovsky, E., Laufer, N., Carel, C. A., Fennig, S., & Mimouni, M. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.07.010 · Cited by 26
Tsai, M.-T., Shaw, C. ‐., Hsiao, K.-J., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000482 · Cited by 25
Figueroa, K. P., Chan, P., Schöls, L. J., et al. (2001) · Archives of Neurology · doi:10.1001/archneur.58.10.1649 · Cited by 24
Glatt, S. J., Faraone, S. V., & Tsuang, M. T. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20048 · Cited by 24
Family-based association analysis of the hSKCa3 potassium channel gene in bipolar disorder
McInnis, M. G., Breschel, T. S., Margolis, R. L., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000492 · Cited by 23
A Highly Polymorphic Poly‐Glutamine Stretch in the Potassium Channel KCNN3 in Migraine
Mößner, R., Weichselbaum, A., Marziniak, M., et al. (2005) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2005.05027.x · Cited by 22
Allosteric Modulation of Ion Channels: The Case of Maxi-K
Rothberg, B. S. (2004) · Science s STKE · doi:10.1126/stke.2272004pe16 · Cited by 22
Koronyo‐Hamaoui, M., Gak, E., Stein, D. J., Frisch, A., Danziger, Y., Leor, S., Michaelovsky, E., Laufer, N., Carel, C. A., Fennig, S., et al. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20154 · Cited by 22
Ujike, H., Yamamoto, A., Tanaka, Y., et al. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00229-3 · Cited by 22
Wittekindt, O. H., Schwab, S. G., Burgert, E., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000495 · Cited by 21
Stackman, R. W., Bond, C. T., & Adelman, J. P. (2008) · Learning & Memory · doi:10.1101/lm.906808 · Cited by 20
Spontaneous Apamin-Sensitive Hyperpolarizations in Dopaminergic Neurons of Neonatal Rats
Seutin, V., Massotte, L., Scuvée‐Moreau, J., et al. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.6.3361 · Cited by 19
Meira‐Lima, I., Zhao, J., Sham, P. C., et al. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000898 · Cited by 17
Sander, T., Schölz, L., Janz, D., Epplen, J. T., & Rieß, O. (1999) · Epilepsy Research · doi:10.1016/s0920-1211(98)00093-x · Cited by 15
The human Ca2+-activated K+ channel, IK, can be blocked by the tricyclic antihistamine promethazine
Wittekindt, O. H., Schmitz, A., Lehmann‐Horn, F., et al. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.10.005 · Cited by 15
Characterization of the outer pore region of the apamin-sensitive Ca2+-activated K+ channel rSK2
Jäger, H., & Grissmer, S. (2004) · Toxicon · doi:10.1016/j.toxicon.2004.03.025 · Cited by 15
Rohrmeier, T., Putzhammer, A., Schoeler, A., et al. (1999) · Psychiatric Genetics · doi:10.1097/00041444-199912000-00001 · Cited by 14
Modeling the paramyxovirus hemagglutinin-neuraminidase protein
Epa, V. C. (1997) · Proteins Structure Function and Bioinformatics · doi:10.1002/(sici)1097-0134(199711)29:3 · Cited by 14
Meissner, B., Purmann, S., Schürmann, M., et al. (1999) · Psychiatric Genetics · doi:10.1097/00041444-199906000-00007 · Cited by 14
Laurent‐Levinson, C., Niehaus, D. J. H., Bauché, S., et al. (2002) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10797 · Cited by 14
Chowdari, K. V., Wood, J. A., Ganguli, R., Gottesman, I. I., & Nimgaonkar, V. L. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000694 · Cited by 13
Sequential and opposite regulation of two outward K+currents by ET-1 in cultured striatal astrocytes
Bychkov, R., Glowinski, J., & Giaume, C. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.4.c1373 · Cited by 13
Yanovsky, Y., Velte, S., & Misgeld, U. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117622 · Cited by 11
Visan, V., Sabatier, J., & Grissmer, S. (2004) · Toxicon · doi:10.1016/j.toxicon.2003.12.011 · Cited by 11
Ivković, M., Rankovic, V., Tarasjev, A., et al. (2006) · International Journal of Neuroscience · doi:10.1080/00207450341514 · Cited by 10
Fujita, A., Takeuchi, T., Hanai, J., et al. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0752-y · Cited by 9
Otis, T. S., & Jen, J. C. (2006) · Nature Neuroscience · doi:10.1038/nn0306-297 · Cited by 7
Association study of CAG repeats in the KCNN3 gene in Israeli patients with major psychosis
Ritsner, M. S., Amir, S., Koronyo‐Hamaoui, M., et al. (2003) · Psychiatric Genetics · doi:10.1097/00041444-200309000-00002 · Cited by 6
CAG repeats of CTG18.1 and KCNN3 in Korean patients with bipolar affective disorder
Jin, D., Hwang, H. Z., Oh, M. R., et al. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00291-3 · Cited by 6
Lack of association between the hKCa3 gene and Japanese schizophrenia patients
Imamura, A., Tsujita, T., Kayashima, T., et al. (2001) · Psychiatric Genetics · doi:10.1097/00041444-200112000-00009 · Cited by 5
Bowen, T., Ashworth, L. M., Kirov, G., et al. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.020406.x · Cited by 3
Stress-induced expressionc-fos in the rat brain: A comparison of averaging and typological analysis
Babaei, P., Dolgov, O., Судаков, К. В., & Анохин, К. В. (2000) · Neuroscience Research Communications · doi:10.1002/1520-6769(200009/10)27:2 · Cited by 2
Curtain, R. P., Sundholm, J., Lea, R. A., et al. (2005) · BMC Medical Genetics · doi:10.1186/1471-2350-6-32 · Cited by 1
Jonnal (2000) · doi:10.1002/1096-8628(20001204)96:6
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Metadata
- Authors
- Pedarzani, P., & Stocker, M.
- Affiliations
- University College London (GB)
- Corresponding author
- Pedarzani, P.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2008-07-04
- Volume
- 65
- Issue
- 20
- Pages
- 3196-3217
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC2798969
- OpenAlex
- W2033849297
- Cited by
- 173
- References
- 266
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 11 · 2021: 5 · 2020: 11 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 14 · 2013: 12 · 2012: 22
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cellular and Molecular Life Sciences (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- small conductance calcium-activated potassium channels, intermediate-conductance calcium-activated potassium channel, apamin, afterhyperpolarization, hippocampal long-term potentiation, neuronal excitability, calcium signaling, glia, cerebral vasculature, synaptic function, dopaminergic neurons, cerebellar neurons, neuronal dysfunction, therapeutic target
- MeSH terms
- Amino Acid Sequence, Animals, Mental Disorders, Brain, Humans, Molecular Sequence Data, Neurons, Small-Conductance Calcium-Activated Potassium Channels, Intermediate-Conductance Calcium-Activated Potassium Channels
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