Ion channels and signaling in the pituitary gland
Open accessAbstract
Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium, calcium, potassium, and chloride channels and fire action potentials spontaneously, accompanied by a rise in intracellular calcium.In some cells, spontaneous electrical activity is sufficient to drive the intracellular calcium concentration above the threshold for stimulus-secretion and stimulus-transcription coupling.In others, the function of these action potentials is to maintain the cells in a responsive state with cytosolic calcium near, but below, the threshold level.Some pituitary cells also express gap junction channels, which could be used for intercellular Ca 2ϩ signaling in these cells.Endocrine cells also express extracellular ligand-gated ion channels, and their activation by hypothalamic and intrapituitary hormones leads to amplification of the pacemaking activity and facilitation of calcium influx and hormone release.These cells also express numerous G protein-coupled receptors, which can stimulate or silence electrical activity and action potential-dependent calcium influx and hormone release.Other members of this receptor family can activate calcium channels in the endoplasmic reticulum, leading to a cell type-specific modulation of electrical activity.This review summarizes recent findings in this field and our current understanding of the complex relationship between voltage-gated ion channels, ligand-gated ion channels, gap junction channels, and G protein-coupled receptors in pituitary cells.(Endocrine Reviews 31: 845-915, 2010) I. Introduction II.Pituitary Cell Types A. POMC-producing cells B. Heterodimeric glucoprotein-producing cells C. GH-and PRL-producing cells D. Nonsecretory cells III.Ion Channels Expressed in Pituitary Cells A. Voltage-gated channels B. Chloride channels and transporters C. Channels expressed in and controlled by the endoplasmic reticulum IV.Spontaneous Electrical Activity A. Spiking and bursting B. Pacemaking mechanisms C. Channels involved in spike depolarization D. A mechanism for bursting E. Functional roles of spontaneous spiking V. Signaling by Gap Junction Channels A. Connexins B. Pannexins VI.Signaling by Receptor Channels A. Cys-loop family of receptor channels B. Glutamate receptor channels C. Purinergic receptor channels VII.Role of GPCRs in the Regulation of Electrical Activity A. Stimulation of electrical activity by GPCRs B. Inhibition of electrical activity by GPCRs VIII.Calcium-Mobilizing Receptors and Electrical Activity A. The dynamics of Ca 2ϩ release B. Calcium mobilization and secretion IX.
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The five endocrine cell types of the anterior pituitary generate electrical activity in the form of spikes and bursts.
“Like alpha and beta cells in the pancreas, the five endocrine cell types of the anterior pituitary generate electrical activity in the form of spikes and bursts [69].”
From Mathematical Modelling of Endocrine Systems (2019) · cites this paper as [69]
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Mathematical Modelling of Endocrine Systems
Zavala, E., Wedgwood, K. C. A., Voliotis, M., Tabak, J., Spiga, F., Lightman, S. L., & Tsaneva-Atanasova, K. (2019) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.01.008 · Cited by 81 · see citing works
“Hybrid Systems: A New Paradigm to Establish How the Parts Contribute to the Whole Like alpha and beta cells in the pancreas, the five endocrine cell types of the anterior pituitary generate electrical activity in the form of spikes and bursts [69].”
Self-citationTabak, J., Tomaiuolo, M., Gonzalez-Iglesias, A. E., Milescu, L. S., & Bertram, R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3235-11.2011 · Cited by 63 · see citing works
Self-citationChemical modulation of Kv7 potassium channels
Borgini, M., Mondal, P., Liu, R., & Wipf, P. (2021) · RSC Medicinal Chemistry · doi:10.1039/d0md00328j · Cited by 37 · see citing works
Mathematical modeling of gonadotropin-releasing hormone signaling
Pratap, A., Garner, K. L., Voliotis, M., Tsaneva-Atanasova, K., & McArdle, C. A. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.022 · Cited by 35 · see citing works
- Authors
- Stojilkovic, S. S., Tabak, J., & Bertram, R.
- Affiliations
- Section on Cellular Signaling (S.S.S.), Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-4510;
- Department of Biological Science (J.T.) Florida State University, Tallahassee, Florida 32306
- Florida State University (US)
- ORCID
- Bertram, Richard
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2010-12-01
- Volume
- 31
- Issue
- 6
- Pages
- 845-915
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- PMC
- PMC3365841
- OpenAlex
- W1991106585
- Cited by
- 229
- References
- 769
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 8 · 2023: 13 · 2022: 27 · 2021: 13 · 2020: 23 · 2019: 15 · 2018: 7 · 2017: 20 · 2016: 21 · 2015: 17 · 2014: 14 · 2013: 13 · 2012: 12
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK 43,200)
- National Institute on Drug Abuse (R01DA019356, DA19356)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 43200, R01DK043200)
- National Institute of Child Health and Human Development
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- pituitary gland, voltage-gated ion channels, ligand-gated ion channels, gap junction channels, G protein-coupled receptors, spontaneous electrical activity, action potential, intracellular calcium signaling, hormone secretion, pacemaking, connexins, pannexins, Cys-loop receptors, glutamate receptors, purinergic receptors, endoplasmic reticulum calcium channels
- MeSH terms
- Action Potentials, Calcium, Humans, Ion Channels, Pituitary Gland, Signal Transduction, Patch-Clamp Techniques, Receptors, G-Protein-Coupled
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