The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease
Open accessAbstract
Abstract.The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved transcription factors that are found in diverse organisms that range from flatworms to humans. These factors are expressed within, and play pivotal developmental roles in, cell populations that give rise to the head, retina, ear, nose, brain, kidney, muscle and gonads. Mutations within the fly and mammalian versions of these genes have adverse consequences on the development of these organs/tissues. Several SIX proteins have been shown to directly influence the cell cycle and are present at elevated levels during tumorigenesis and within several cancers. This review aims to highlight aspects of (1) the evolutionary history of the SIX family; (2) the structural differences and similarities amongst the different SIX proteins; (3) the role that these genes play in retinal development; and (4) the influence that these proteins have on cell proliferation and growth.
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Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function
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Metadata
- Authors
- Kumar, J. P.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2008-11-08
- Volume
- 66
- Issue
- 4
- Pages
- 565-583
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W1963945273
- Cited by
- 252
- References
- 110
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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