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Cited by 350Protein Kinase Regulation and GTPase SignalingCellular transport and secretionCellular Mechanics and Interactions

Rac1 GTPase: A “Rac” of All Trades

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Bosco, E. E., Mulloy, J. C., Zheng, Y.·2009·Cellular and Molecular Life Sciences
DOI 10.1007/s00018-008-8552-xPMC PMC6669905
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Abstract

Rac1, a member of the Rho family of GTPases, is an intracellular transducer known to regulate multiple signaling pathways that control cytoskeleton organization, transcription, and cell proliferation. Deregulated expression or activation patterns of Rac1 can result in aberrant cell signaling and numerous pathological conditions. Here, we highlight the physiological functions and signaling mechanisms of Rac1 and their relevance to disease.

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Cited by

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Authors
Bosco, E. E., Mulloy, J. C., & Zheng, Y.
Affiliations
Cincinnati Children's Hospital Medical Center (US)
Corresponding author
Zheng, Y.
ORCID
Venue
Cellular and Molecular Life Sciences
Publisher
Springer Science and Business Media LLC
Published
2008-12-30
Volume
66
Issue
3
Pages
370-374
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
DOI
10.1007/s00018-008-8552-x
PMC
PMC6669905
OpenAlex
W1996107157
Cited by
350
References
0
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FWCI
7.82
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (T32CA117846)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
Rac1, Rho GTPases, signal transduction, cytoskeletal organization, transcriptional regulation, cell proliferation, Rac1 activation, disease relevance
MeSH terms
Actins, Animals, Endocytosis, Humans, Signal Transduction, Reactive Oxygen Species, Protein Isoforms, rac GTP-Binding Proteins

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