Cited by 43Exercise and Physiological ResponsesRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

The basic chemistry of exercise-induced DNA oxidation: oxidative damage, redox signaling, and their interplay

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Cobley, James N., Margaritelis, Nikos V., Morton, James P., Close, Graeme L., Nikolaidis, Michalis G., Malone, John K.·2015·Frontiers in Physiology

Abstract

Acute exercise increases reactive oxygen and nitrogen species generation. This phenomenon is associated with two major outcomes: (1) redox signaling and (2) macromolecule damage. Mechanistic knowledge of how exercise-induced redox signaling and macromolecule damage are interlinked is limited. This review focuses on the interplay between exercise-induced redox signaling and DNA damage, using hydroxyl radical ((·)OH) and hydrogen peroxide (H2O2) as exemplars. It is postulated that the biological fate of H2O2 links the two processes and thus represents a bifurcation point between redox signaling and damage. Indeed, H2O2 can participate in two electron signaling reactions but its diffusion and chemical properties permit DNA oxidation following reaction with transition metals and (·)OH generation. It is also considered that the sensing of DNA oxidation by repair proteins constitutes a non-canonical redox signaling mechanism. Further layers of interaction are provided by the redox regulation of DNA repair proteins and their capacity to modulate intracellular H2O2 levels. Overall, exercise-induced redox signaling and DNA damage may be interlinked to a greater extent than was previously thought but this requires further investigation.

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Crossref · 10.3389/fphys.2015.00182

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  • Exercise-induced disruptions in skeletal muscle homeostasis regulate exercise adaptations with repeated activation.

    “It is now well recognized that exercise-induced disruptions in skeletal muscle homeostasis regulate exercise adaptations with repeated activation [148,149] (Figure 1)”
  • Repeated exercise bouts (training) induce disruption in skeletal muscle homeostasis that regulate training adaptations.

    “It is accepted that repeated exercise bouts (i.e. training) induce disruption in skeletal muscle homeostasis that regulate training adaptations [62,63].”

    From Sleep and Nutrition Interactions: Implications for Athletes (2019) · cites this paper as [62]

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  1. Halliwell B. Gutteridge J. M. G. (2007). Free Radicals in Biology and Medicine, 4th Edn. Oxford: Oxford University Press.

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Authors
Cobley, J. N., Margaritelis, N. V., Morton, J. P., Close, G. L., Nikolaidis, M. G., & Malone, J. K.
Affiliations
  • Abertay University (GB)
  • Aristotle University of Thessaloniki (GR)
  • Liverpool John Moores University (GB)
Corresponding author
Cobley, James N.
Venue
Frontiers in Physiology
Published
2015-06-17
Volume
6
Pages
182-182
ISSN
1664-042X (ISSN-L)
OpenAlex
W1588923203
Cited by
43
References
87
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 3
FWCI
4.37
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Abertay Research Portal (Abertay University) (acceptedVersion, cc-by)
  • Discovery Research Portal (University of Dundee) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
University of Otago
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
oxidative DNA damage, redox signaling, hydrogen peroxide, hydroxyl radicals, reactive oxygen species, reactive nitrogen species, transition metal catalysis, DNA repair proteins, exercise physiology

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