The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo
Open accessAbstract
The apical junctional complex (AJC), composed of tight and adherens junctions, maintains epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary disease (COPD), the major smoking-induced disease, are associated with increased lung epithelial permeability, we hypothesized that smoking alters the transcriptional program regulating airway epithelial AJC integrity. Transcriptome analysis revealed global down-regulation of physiological AJC gene expression in the airway epithelium of healthy smokers (n = 59) compared to nonsmokers (n = 53) in association with changes in canonical epithelial differentiation pathways such as PTEN signaling accompanied by induction of cancer-related AJC components. The overall expression of AJC-related genes was further decreased in COPD smokers (n = 23). Exposure of airway epithelial cells to cigarette smoke extract in vitro resulted in down-regulation of several AJC genes paralleled by decreased transepithelial resistance. Thus, cigarette smoking induces transcriptional reprogramming of airway epithelial AJC architecture from its physiological pattern necessary for barrier function toward a disease-associated molecular phenotype.
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Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Rabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., Fukuchi, Y., Jenkins, C., Rodriguez-Roisin, R., van Weel, C., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-456so · Cited by 4,925
Biomarkers for epithelial-mesenchymal transitions
Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299 · cited 5×
“Upregulation of CDH2 and downregulation of CDH1 are the central EMT features in human lung cancer [28].”
BackgroundInfluentialPolycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
Cited by
Pulmonary-intestinal cross-talk in mucosal inflammatory disease
Keely, S., Talley, N. J., & Hansbro, P. M. (2012) · Mucosal Immunology · doi:10.1038/mi.2011.55 · Cited by 386
Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes
Borghardt, J. M., Kloft, C., & Sharma, A. (2018) · Canadian Respiratory Journal · doi:10.1155/2018/2732017 · Cited by 304
Molecular Processes that Drive Cigarette Smoke–Induced Epithelial Cell Fate of the Lung
Nyunoya, T., Mebratu, Y., Contreras, A., Delgado, M., Chand, H. S., & Tesfaigzi, Y. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0348tr · Cited by 110
Metadata
- Authors
- Shaykhiev, R., Otaki, F., Bonsu, P., Dang, D. T., Teater, M., Strulovici-Barel, Y., Salit, J., Harvey, B.-G., & Crystal, R. G.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2010-09-06
- Volume
- 68
- Issue
- 5
- Pages
- 877-892
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W1971088574
- Cited by
- 228
- References
- 4
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Shaykhiev, R., Otaki, F., Bonsu, P., Dang, D. T., Teater, M., Strulovici-Barel, Y., Salit, J., Harvey, B.-G., & Crystal, R. G. (2011). Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-010-0500-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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