Cited by 127DNA Repair MechanismsFungal and yeast genetics researchCancer-related Molecular Pathways

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Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

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Finn, Karen, Lowndes, Noel Francis, Grenon, Muriel·2012·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-011-0875-3PMC PMC11115150

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Abstract

Double-strand breaks (DSBs) are the most detrimental form of DNA damage. Failure to repair these cytotoxic lesions can result in genome rearrangements conducive to the development of many diseases, including cancer. The DNA damage response (DDR) ensures the rapid detection and repair of DSBs in order to maintain genome integrity. Central to the DDR are the DNA damage checkpoints. When activated by DNA damage, these sophisticated surveillance mechanisms induce transient cell cycle arrests, allowing sufficient time for DNA repair. Since the term "checkpoint" was coined over 20 years ago, our understanding of the molecular mechanisms governing the DNA damage checkpoint has advanced significantly. These pathways are highly conserved from yeast to humans. Thus, significant findings in yeast may be extrapolated to vertebrates, greatly facilitating the molecular dissection of these complex regulatory networks. This review focuses on the cellular response to DSBs in Saccharomyces cerevisiae, providing a comprehensive overview of how these signalling pathways function to orchestrate the cellular response to DNA damage and preserve genome stability in eukaryotic cells.

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Authors: Finn, K., Lowndes, N. F., & Grenon, M.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
Corresponding author: Lowndes, Noel Francis
Grenon, Muriel
ORCID: Finn, Karen
Lowndes, Noel Francis
Grenon, Muriel
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2011-11-15
Volume: 69
Issue: 9
Pages: 1447-1473
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-011-0875-3
PMC: PMC11115150
OpenAlex: W1991917259
Cited by: 127
References: 399
Citations by year: 2026: 6 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 14 · 2018: 12 · 2017: 15 · 2016: 7 · 2015: 9 · 2014: 15 · 2013: 16 · 2012: 3
FWCI: 0.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: DNA damage checkpoint, DNA double-strand breaks, DNA damage response, genome stability, cell cycle arrest, DNA repair, Saccharomyces cerevisiae, genome rearrangement, cancer
MeSH terms: Checkpoint Kinase 1, Cell Cycle, DNA Damage, Humans, Models, Biological, Models, Genetic, Protein Kinases, Saccharomyces cerevisiae, Signal Transduction, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Saccharomyces cerevisiae Proteins, Genomic Instability, DNA Breaks, Double-Stranded, Eukaryota, Cell Cycle Checkpoints, Checkpoint Kinase 2

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Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

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