The DOI matches its Crossref record; 399 of the 399 references it cites were found in a registry or an index.
Eukaryotic DNA damage checkpoint activation in response to double-strand breaks
Open accessAbstract
Double-strand breaks (DSBs) are the most detrimental form of DNA damage. Failure to repair these cytotoxic lesions can result in genome rearrangements conducive to the development of many diseases, including cancer. The DNA damage response (DDR) ensures the rapid detection and repair of DSBs in order to maintain genome integrity. Central to the DDR are the DNA damage checkpoints. When activated by DNA damage, these sophisticated surveillance mechanisms induce transient cell cycle arrests, allowing sufficient time for DNA repair. Since the term "checkpoint" was coined over 20 years ago, our understanding of the molecular mechanisms governing the DNA damage checkpoint has advanced significantly. These pathways are highly conserved from yeast to humans. Thus, significant findings in yeast may be extrapolated to vertebrates, greatly facilitating the molecular dissection of these complex regulatory networks. This review focuses on the cellular response to DSBs in Saccharomyces cerevisiae, providing a comprehensive overview of how these signalling pathways function to orchestrate the cellular response to DNA damage and preserve genome stability in eukaryotic cells.
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“ATM-Chk2 dependent DDR is activated primarily in response to DSBs (Fig. 7) [44].”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [44]
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Metadata
- Authors
- Finn, K., Lowndes, N. F., & Grenon, M.
- Affiliations
- Ollscoil na Gaillimhe – University of Galway (IE)
- Corresponding author
- Lowndes, Noel Francis
- Grenon, Muriel
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2011-11-15
- Volume
- 69
- Issue
- 9
- Pages
- 1447-1473
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11115150
- OpenAlex
- W1991917259
- Cited by
- 127
- References
- 399
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 14 · 2018: 12 · 2017: 15 · 2016: 7 · 2015: 9 · 2014: 15 · 2013: 16 · 2012: 3
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- DNA damage checkpoint, DNA double-strand breaks, DNA damage response, genome stability, cell cycle arrest, DNA repair, Saccharomyces cerevisiae, genome rearrangement, cancer
- MeSH terms
- Checkpoint Kinase 1, Cell Cycle, DNA Damage, Humans, Models, Biological, Models, Genetic, Protein Kinases, Saccharomyces cerevisiae, Signal Transduction, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Saccharomyces cerevisiae Proteins, Genomic Instability, DNA Breaks, Double-Stranded, Eukaryota, Cell Cycle Checkpoints, Checkpoint Kinase 2
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