Cited by 1,485Gut microbiota and healthProbiotics and Fermented FoodsOral microbiology and periodontitis research

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An insight into gut microbiota and its functionalities

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Adak, Atanu, Khan, Mojibur R.·2019·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-018-2943-4PMC PMC11105460

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Abstract

Gut microbiota has evolved along with their hosts and is an integral part of the human body. Microbiota acquired at birth develops in parallel as the host develops and maintains its temporal stability and diversity through adulthood until death. Recent developments in genome sequencing technologies, bioinformatics and culturomics have enabled researchers to explore the microbiota and in particular their functions at more detailed level than before. The accumulated evidences suggest that though a part of the microbiota is conserved, the dynamic members vary along the gastrointestinal tract, from infants to elderly, primitive tribes to modern societies and in different health conditions. Though the gut microbiota is dynamic, it performs some basic functions in the immunological, metabolic, structural and neurological landscapes of the human body. Gut microbiota also exerts significant influence on both physical and mental health of an individual. An in-depth understanding of the functioning of gut microbiota has led to some very exciting developments in therapeutics, such as prebiotics, probiotics, drugs and faecal transplantation leading to improved health.

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Authors: Adak, A., & Khan, M. R.
Affiliations: Institute of Advanced Study in Science and Technology (IN)
Corresponding author: Khan, Mojibur R.
ORCID: Adak, Atanu
Khan, Mojibur R.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2018-10-13
Volume: 76
Issue: 3
Pages: 473-493
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-018-2943-4
PMC: PMC11105460
OpenAlex: W2896269751
Cited by: 1,485
References: 181
Citations by year: 2026: 191 · 2025: 393 · 2024: 372 · 2023: 232 · 2022: 176 · 2021: 90 · 2020: 22 · 2019: 8
FWCI: 2.94
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Department of Science and Technology, India (under Unit of Excellence Project (BT/550/NE/U-Excel/2014))
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: gut microbiota, microbiome diversity, microbiota dynamics, gastrointestinal tract, host immunity, host metabolism, prebiotics, probiotics, microbiota-based therapy, fecal microbiota transplantation, culturomics
MeSH terms: Gastrointestinal Microbiome, Humans, Symbiosis, Computational Biology, Gastrointestinal Tract

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